ʻO ka waikawa Guanidinoacetic (GAA) a i ʻole GlycocyamineʻO ia ka biochemical precursor o ka creatine, ʻo ia ka phosphorylated. He kuleana koʻikoʻi ia ma ke ʻano he mea lawe ikaika nui i ka ʻiʻo. ʻO Glycocyamine maoli ka metabolite o ka glycine kahi i hoʻololi ʻia ai ka hui amino i kahi guanidine. Hiki ke hoʻohana ʻia ka waikawa Guanidinoacetic e hoʻonui ai i ka ikaika o ka ʻiʻo a e hōʻemi i ka luhi ʻiʻo. A e hoʻohui i ka waikawa guanidinoacetic i loko o ka meaʻai hiki ke hoʻomaikaʻi maikaʻi i ke kino o ka puaʻa lean. Hiki ke noʻonoʻo ʻia ʻo GAA he ala hou e hoʻomaikaʻi ai i ka hana hoʻoikaika kino. Ua manaʻo ʻia i kēia manawa he ala hiki ke hana i ka creatine e hoʻoponopono i nā pae creatine lolo i ka lāʻau hoʻokolohua. Ma muli o ka hoʻonui ʻia ʻana o ka bioavailability a me ka hoʻohana maʻalahi o ka pūhui, ʻo ka lawe ʻana i ka GAA ma ka waha he mea pono paha no nā maʻi AGAT. Akā he mau drawbacks e like me nā pilikia methylation lolo, neurotoxicity, a me hyperhomocysteinemia.

Mai nā haʻawina ua ʻike ʻia he hui pū ʻana obetaine a me glycocyaminehoʻomaikaʻi i nā hōʻailona o ka poʻe maʻi me ka maʻi maʻi, me ka maʻi puʻuwai, me ka ʻole o ka ʻona. Hāʻawi ʻo Betaine i ka hui methyl i ka glycocyamine, ma o ka methionine, no ka hoʻokumu ʻana i ka creatine. Ma muli o kēia, ua emi ka luhi, ka ikaika a me ka hoʻomanawanui, a me ka maikaʻi o ka maikaʻi. He mea maikaʻi nō hoʻi ia no nā poʻe maʻi me ka decompensation cardiac (arteriosclerosis a i ʻole maʻi rheumatic) a me ka puʻuwai congestive no ka hoʻomaikaʻi ʻana i ka hana cardiac. He mea kōkua nō hoʻi i ka loaʻa ʻana o ke kaumaha (hoʻomaikaʻi ʻia ke koena o ka nitrogen) a ʻike i nā hōʻailona hōʻemi o ka ʻāʻī a me ka hānō a me ka piʻi ʻana o ka libido. Ua ʻike ka poʻe i loaʻa i ka hypertension i ka emi ʻana o ke koko. Hoʻonui pū ia i ka ʻae ʻana i ka glucose i ka maʻi maʻi a me ka ʻole o ka maʻi diabetes.

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