Supplementation of tributyrin improves the growth and intestinal digestive and barrier functions in intrauterine growth-restricted piglets

 

The study was to investigate the effects of TB supplementation on the growth of IUGR neonatal piglets.

Methods

Sixteen IUGR and 8 NBW (normal body weight) neonatal piglets were chosen, weaned at 7th day and fed basic milk diets (NBW and IUGR group) or the basic diets supplemented with 0.1% tributyrin (IT group, IUGR piglets fed with tributyrin) until day 21 (n = 8). The body weights of the piglets on days 0, 7, 10, 14, 17, and 20 were measured. The digestive enzyme activity, intestinal morphology, immunoglobulin levels and gene expression of IgG, FcRn and GPR41 in the small intestines were analyzed.

Results

The body weights of the piglets in the IUGR and IT group were similar, and both were lower than the NBW group on days 10 and 14. However, after day 17, the IT group exhibited improved (P < 0.05) body weights compared to that of the IUGR group. The piglets were sacrificed on day 21. Compared with the NBW piglets, IUGR impaired the development of immune organs and small intestines, impaired the intestinal villus morphology, decreased (P < 0.05) most of the tested intestinal digestive enzyme activities, decreased (P < 0.05) the ileal sIgA and IgG levels, and down-regulated (P < 0.05) the intestinal IgG and GPR41 expression. Piglets in the IT group exhibited a better-developed (P < 0.05) spleen and small intestines, improved intestinal villus morphology, increased (P < 0.05) intestinal villus surface areas, enhanced (P < 0.05) digestive enzyme activities, and up-regulated (P < 0.05) expression of IgG and GPR41 mRNA compared to those of the IUGR group.

Conclusions

TB supplementation improves the growth and the intestinal digestive and barrier functions in IUGR piglets during the suckling period.
Learn more about the tirbutyrin 
Form: Powder Colour: White To Off-white
Ingredient: Tributyrin Odour: Odourless
Property: Bypass Stomach Function: Growth Promotion, Anti-bacteria
Concentration: 60% Carrier: Silica
CAS Number: 60-01-5
High Light:

Tributyrin 60% Short Chain Fatty Acids

Anti Stress Short Chain Fatty Acids

Feed Additive Short Chain Fatty Acids                                                                                       

20210508103727_78893

Silica Carrier Short Chain Fatty Acid Feed Additive Tributyrin 60% Minimum For Aqua

Name of Product: Ding Su E60 (Tributyrin 60%)

Molecular Formula: C15H26O6 Molecular weight: 302.36

Classification of Product: Feed Additive

Description: White to off White Powder. Good Flowability. Free from Typical Butyric Rancid Odor.

Dosage  kg/mt feed

Swine Aqua
0.5-2.0 1.5-2.0

Package: 25kg per bag net.

Storage: Sealed Tightly. Avoid Exposure To Moisture.

Expiry: Two years from the date of production.


Post time: Jun-30-2022