E le selelekela sa butyric acid,tributyl glycerideke tlatsetso e ntle ea asiti ea butyric e nang le thepa e tsitsitseng ea 'mele le ea lik'hemik'hale, polokeho le litlamorao tse seng chefo.Ha e rarolle bothata feela hore asiti ea butyric e nkha hampe ebile e fetoha habonolo, empa hape e rarolla bothata boo butyric acid e leng thata ho kenngoa ka kotloloho ka mpeng le mala.E na le litebello tse pharaletseng tsa ts'ebeliso lefapheng la phepo ea liphoofolo.Joalo ka sehokelo sa phepelo,tributyl glyceridee ka sebetsa ka kotloloho ts'ebetsong ea tšilo ea lijo ea liphoofolo, ea fana ka matla bakeng sa pampitšana ea mala ea liphoofolo, ea ntlafatsa bophelo ba mala a liphoofolo, le ho laola ts'ebetso ea kholo ea liphoofolo le boemo ba bophelo bo botle.

1. Ntlafatsa ts'ebetso ea kholo

Keketso eatributyl glycerideho fepa ho sebedisoa haholo tlhahisong ya mefuta yohle ya diphoofolo.Ho kenyelletsa tekanyo e nepahetseng ea tributyl glyceride lijong ho ka eketsa boima ba letsatsi le letsatsi ba boima ba liphoofolo tsa liteko, ho fokotsa lijo le boima ba 'mele, le ho ntlafatsa ts'ebetso ea kholo ea liphoofolo.Chelete ea tlatsetso ke 0.075% ~ 0.250%.

2. Ntlafatsa bophelo bo botle ba mala

Tributyrine ka phetha karolo ea bohlokoa ho bophelo bo botle ba mala a liphoofolo ka ho ntlafatsa morphology ea mala le sebopeho, ho laola ho leka-lekana ha limela tsa mala, ho ntlafatsa thibelo ea mala le matla a antioxidant.Phuputso e fumane hore ho eketsa lefuba lijong ho ka eketsa polelo ea protheine e thata ea mala, ho khothalletsa nts'etsopele ea mucosa ea mala, ho ntlafatsa tšilo ea lijo, ho matlafatsa matla a antioxidant, ho fokotsa litaba tsa libaktheria tse kotsi ka har'a mala le ho eketseha. litaba tsa libaktheria tse molemo, li khothalletsa nts'etsopele ea mala a liphoofolo, le ho ntlafatsa bophelo bo botle ba mala a liphoofolo.

Ho na le liphuputso tse ling tse bontšitseng hore ho eketsoa ha lefuba lijong ho ka ntlafatsa haholo ts'ilo e bonahalang ea protheine e tala, mafura a tala le matla a likolobe tse khoesitsoeng, 'me tšilo ea lijo tsa phepo e amana haufi-ufi le bophelo bo botle ba mala a liphoofolo.Ho ka bonoa hore lefuba le khothalletsa ho monya le ho siloa ha limatlafatsi ka maleng.

Keketso eatributyl glyceridee ka eketsa haholo bophahamo ba villus le boleng ba V / C ea mala a likolobe tse khoesoang, ea fokotsa litaba tsa MDA le hydrogen peroxide ka jejunum, ea ntlafatsa ts'ebetso ea mitochondrial, ea fokotsa khatello ea oxidative ho likolobe, le ho khothaletsa nts'etsopele ea mala.

Ho eketsoa ha microencapsulated tributyl glyceride ho ka eketsa bophahamo ba villus ea duodenum le jejunum, ho eketsa litaba tsa baktheria ea lactic acid ka har'a cecum le ho fokotsa litaba tsa Escherichia coli, ho ntlafatsa sebopeho sa mala a likhoho, 'me phello ea lefuba la microencapsulated e betere ho feta. Lefuba la metsi.Ka lebaka la karolo e khethehileng ea rumen ho liphoofolo tse ruminang, ho na le litlaleho tse fokolang tsa liphello tsa tributyl glyceride ho liphoofolo tse ruminang.

Joalo ka matla a mala, tributyrin e khona ho ntlafatsa le ho lokisa morphology le sebopeho sa mala, ho ntlafatsa tšilo ea mala le ho monya, ho khothaletsa ho ata ha libaktheria tse molemo tsa mala, ho ntlafatsa sebopeho sa limela tsa mala, ho fokotsa khatello ea oxidative. karabelo ea liphoofolo, ho khothaletsa nts'etsopele ea mala a liphoofolo, le ho netefatsa bophelo bo botle ba 'mele.

Phuputso e fumane hore tlatsetso e kopaneng eatributyrinle oli ea oregano kapa methyl salicylate lijong tsa likolobe tse khoesitsoeng li ka eketsa boleng ba V / C ba mala, ho ntlafatsa morphology ea mala a likolobe, ho eketsa haholo bongata ba Firmicutes, ho fokotsa bongata ba Proteus, Actinobacillus, Escherichia coli, joalo-joalo. , fetola sebopeho sa limela tsa mala le metabolites, e leng molemo ho bophelo bo botle ba mala a likolobe tse khoesitsoeng, 'me e ka nka sebaka sa lithibela-mafu ha ho sebelisoa likolobe tse khoesitsoeng.

Ka kakaretso,tributyrine na le mefuta e fapaneng ea mesebetsi ea likokoana-hloko tse kang ho fana ka matla bakeng sa 'mele, ho boloka botšepehi ba mala, ho laola sebopeho sa limela tsa mala, ho kenya letsoho liketsong tsa ho itšireletsa mafung le metabolism, joalo-joalo E ka khothalletsa nts'etsopele ea mala a liphoofolo le ho ntlafatsa ts'ebetso ea kholo ea liphoofolo.Glyceryl tributylate e ka bola ka pancreatic lipase ka maleng ho hlahisa butyric acid le glycerol, e ka sebelisoang e le mohloli o sebetsang oa butyric acid ka maleng a liphoofolo.Ha e rarolle feela bothata boo asiti ea butyric e thata ho e kenyelletsa lijong ka lebaka la monko oa eona le ho hloka botsitso, empa hape e rarolla bothata ba hore butyric acid e thata ho kena ka mpeng ka mpeng.Ke moriana o sebetsang hantle haholo, o bolokehileng le o motala oa lithibela-mafu.

Leha ho le joalo, lipatlisiso tsa hajoale mabapi le ts'ebeliso eatributyl glyceridephepong ya diphoofolo e batla e fokola, mme dipatlisiso mabapi le bongata, nako, sebopeho le motswako wa lefuba le dimatlafatsi tse ding di batla di haella.Ho matlafatsa ts'ebeliso ea tributyl glyceride tlhahisong ea liphoofolo e ke ke ea fana ka mekhoa e mecha ea tlhokomelo ea bophelo ba liphoofolo le thibelo ea mafu, empa hape e na le boleng bo boholo ba ts'ebeliso ho nts'etsopele ea li-substitutes tsa lithibela-mafu, tse nang le tebello e pharaletseng ea ts'ebeliso.