Njengomanduleli we-butyric acid,i-tributyl glycerideisongezelelo seasidi ye-butyric eneempawu ezizinzileyo zomzimba kunye neekhemikhali, ukhuseleko kunye neziphumo ebezingalindelekanga ezingezizo ezinetyhefu.Ayisombululi kuphela ingxaki ukuba i-asidi ye-butyric ivumba elibi kwaye i-volatilizes ngokulula, kodwa iphinda isombulule ingxaki yokuba i-asidi ye-butyric kunzima ukuba yongezwe ngokuthe ngqo kwisisu kunye namathumbu.Inamathemba okusebenza ngokubanzi kwintsimi yesondlo sezilwanyana.Njengesongezo sokutya,i-tributyl glycerideinokusebenza ngokuthe ngqo kwindlela yokwetyisa yezilwanyana, inike amandla kumathumbu ezilwanyana, iphucule impilo yamathumbu ezilwanyana, ilawule ukukhula kwezilwanyana kunye nobume bempilo.

1. Ukuphucula ukukhula komsebenzi

Ukongezwa kwei-tributyl glycerideukutya kuye kwasetyenziswa kakhulu kwimveliso yazo zonke iintlobo zezilwanyana.Ukongeza isixa esifanelekileyo se-tributyl glyceride ekutyeni kunokonyusa umndilili wokufumana ubunzima bemihla ngemihla yezilwanyana zovavanyo, ukunciphisa ukutya kumlinganiselo wobunzima, kunye nokuphucula ukukhula kwezilwanyana.Isixa-mali esongezelelweyo yi-0.075%~0.250%.

2. Ukuphucula impilo yamathumbu

I-Tributyrininokudlala indima esebenzayo kwimpilo yamathumbu ezilwanyana ngokuphucula i-intestinal morphology kunye nesakhiwo, ukulawula ukulinganisela kweentyatyambo zamathumbu, ukuphucula umqobo wamathumbu kunye nomthamo we-antioxidant.Uphononongo lufumene ukuba ukongeza i-TB ekudleni kunokunyusa ukubonakaliswa kwamathumbu e-intestinal tight junction protein, ukukhuthaza ukuphuhliswa kwe-intestinal mucosa, ukuphucula ukugaywa kwesondlo sezondlo, ukuphucula amandla e-antioxidant, ukunciphisa umxholo webhaktheriya eyingozi kwi-intestinal tract kunye nokwandisa. umxholo webhaktheriya enenzuzo, ukukhuthaza ukuphuhliswa kwamathumbu ezilwanyana, kunye nokuphucula impilo yamathumbu ezilwanyana.

Kukho amaphononongo abonisa ukuba ukongezwa kwe-TB ekutyeni kunokuphucula ngokubonakalayo ukugaywa okubonakalayo kweprotheyini ekrwada, amafutha akrwada kunye namandla amantshontsho eehagu ezilunyulweyo, kwaye ukugaywa kwezondlo zesondlo kunxulumene ngokusondeleyo nempilo yamathumbu esilwanyana.Kuyabonakala ukuba i-TB ikhuthaza ukufunxwa kunye nokwetyisa izondlo emathunjini.

Ukongezwa kwei-tributyl glycerideinokunyusa kakhulu ukuphakama kwe-villus kunye ne-V / C ixabiso le-intestinal tract of beaning piglets, ukunciphisa umxholo we-MDA kunye ne-hydrogen peroxide kwi-jejunum, ukuphucula umsebenzi we-mitochondrial, ukunciphisa uxinzelelo lwe-oxidative kwiihagu, kunye nokukhuthaza ukuphuhliswa kwamathumbu.

Ukongezwa kwe-microencapsulated tributyl glyceride kunokunyusa kakhulu ukuphakama kwe-villus ye-duodenum kunye ne-jejunum, ukwandisa umxholo we-lactic acid bacteria kwi-cecum kunye nokunciphisa umxholo we-Escherichia coli, ukwandisa ukwakheka kweentyatyambo zamathumbu e-broilers, kunye nesiphumo se-TB esincinci singcono kune-TB. leyo ye-TB engamanzi.Ngenxa yendima ekhethekileyo yerumen kwiiruminants, kukho iingxelo ezimbalwa malunga nemiphumo ye-tributyl glyceride kwiiruminants.

Njengomthombo wamandla emathunjini, i-tributyrin inokuphucula ngokufanelekileyo kwaye ilungise i-morphology kunye nokwakheka kwamathumbu, iphucule ukugaywa kunye nomthamo wokufunxa wamathumbu, ikhuthaze ukwanda kweebhaktheriya eziluncedo emathunjini, ukuphucula ubume beflora yamathumbu, ukunciphisa uxinzelelo lwe-oxidative. ukusabela kwezilwanyana, ukukhuthaza ukukhula kwamathumbu ezilwanyana, kunye nokuqinisekisa impilo yomzimba.

Uphononongo lufumanise ukuba udibaniso oludityanisiweyo lwei-tributyrinkunye neoli ye-oregano okanye i-methyl salicylate ekudleni kweengulube ezilunyuliweyo zinokunyusa ixabiso le-V / C lamathumbu, ukuphucula i-intestinal morphology yeengulube, ukwandisa kakhulu ubuninzi be-Firmicutes, ukunciphisa ubuninzi beProteus, Actinobacillus, Escherichia coli, njl. , utshintshe i-intestinal flora structure kunye ne-metabolites, enenzuzo kwimpilo yamathumbu eehagu ezilunyuliweyo, kwaye inokutshintsha i-antibiotics ekusetyenzisweni kweehagu ezilunyuliweyo.

Nje,i-tributyrininemisebenzi eyahlukeneyo yezinto eziphilayo ezifana nokubonelela ngamandla emzimbeni, ukugcina ingqibelelo yamathumbu, ukulawula ukwakheka kweentyatyambo zamathumbu, ukuthatha inxaxheba kwi-immune kunye ne-metabolic reactions, njl.I-Glyceryl tributylate inokuboliswa yi-pancreatic lipase emathunjini ukuze ivelise i-asidi ye-butyric kunye ne-glycerol, enokusetyenziswa njengomthombo osebenzayo we-butyric acid emathunjini ezilwanyana.Ayinasombulula ingxaki kuphela ukuba i-asidi ye-butyric kunzima ukongeza kwisondlo ngenxa yevumba layo kunye nokuguquguquka kwayo, kodwa iphinda isombulule ingxaki yokuba i-asidi ye-butyric kunzima ukungena emathunjini ngokusebenzisa isisu.Yeyona ndawo isebenzayo, ekhuselekileyo neluhlaza yesithinteli-ntsholongwane.

Nangona kunjalo, uphando lwangoku malunga nokusetyenziswa kwei-tributyl glyceridekwisondlo sezilwanyana zimbalwa, kwaye uphando malunga nesixa, ixesha, uhlobo kunye nendibaniselwano ye-TB kunye nezinye izondlo zinqongophele.Ukomeleza ukusetyenziswa kwe-tributyl glyceride kwimveliso yezilwanyana ayikwazi ukubonelela ngeendlela ezintsha zokunakekelwa kwempilo yezilwanyana kunye nokuthintela izifo, kodwa kunye nexabiso elikhulu lesicelo ekuphuhliseni ama-antibiotic substitutes, kunye nethemba elibanzi lesicelo.