Guanylacetic acid, sidoo kale loo yaqaan guanylacetic acid, waa analoog amino acid ah oo laga sameeyay glycine iyo L-lysine.

Guanylacetic acid waxa ay ku abuurmi kartaa creatine iyada oo hoos timaada catalysis of enzymes waana shardiga kaliya ee looga baahan yahay isku dhafka creatine.Creatine waxaa loo aqoonsan yahay inuu yahay tamarta tamarta, shaqadeeda ugu weynna waa inay sameyso creatine phosphorylated oo hoos timaada ficilka creatine kinase.

Ka qayb qaado safarka adenosinewareegga isbitaalka (ATP).Marka tamarta ATP ay ku filnaato, phosphocreatine waxay si degdeg ah ugu wareejisaa kooxda phosphate adenosine diphosphate iyada oo loo marayo creatine kinase oo dib ugu celisa adenosine triphosphate.

 

Codsiga ku jira adhijirrada:

Ku darista 0.12%, 0.08%, iyo 0.04% guanylacetic acid ee cuntada 120 barn la quudiyo Tan idaha oo miisaankeedu yahay 20 kiiloogaraam, siday u kala horreeyaan, waxay muujisay in lagu daro 0.12% iyo 0.08% guanylacetic acid ay si weyn u kordhisay korodhka miisaanka maalinlaha ah, dufanka muruqyada, iyo waxa ku jira borotiinka, iyo waxa ku jira dufanka bakhtiga oo aad hoos u dhacay.

 

Kordhinta 0.08%guanylacetic acidayaa kordhay boqolkiiba 9.77 hilibka saafiga ah.Iyada oo la adeegsanayo habka wax soo saarka gaaska vitro, saamaynta ku darista heerar kala duwan oo ah guanylacetic acid ee rumen ee lo'da jaalaha ah ayaa la bartay.Waxaa la ogaaday in ku darida 0.4% guanylacetic acid ay si weyn u kordhisay wax soo saarka gaaska, iyo xoojinta nitrogen ammonia markii hore ayaa kordhay ka dibna hoos u dhacay.

Sidaa darteed, waxaa la qiyaasi karaa in lagu daro guanylacetic acid quudinta maalinlaha ah waxay hagaajin kartaa deegaanka gudaha ee rumen iyo habka halsano ee lo'da jaalaha ah.

Codsiga digaaga:

Ku darista 800 mg / kg, 1600 mg / kg, 4000 mg / kg, iyo 8000 mg / kg ee guanylacetic acid quudinta maalinlaha ah ee broilers waxay muujisay in ku darista 800-4000 mg / kg ee guanylacetic acid quudinta waxay si weyn u kordhisay miisaanka maalinlaha ah. korodhka broilers, waxay hoos u dhigtay quudinta miisaanka miisaanka broilers 22-42 maalmood da'da.Ku darista 8000 mg / kg ee guanylacetic acid waxay hagaajisay tilmaamayaasha biochemical ee serum sida nitrogen urea, tilmaamayaasha joogtada ah ee dhiigga, iyo wadarta bilirubin Ma jirin wax saameyn ah oo muhiim ah oo ku saabsan tilmaamayaasha xubnaha waaweyn, taas oo muujinaysa in lagu daro 8000 mg / kg guanylacetic acid quudinta maalinlaha ah ee broilers. waa loo dulqaadan karaa.

Ku darida 200 mg / kg, 400 mg / kg, 600 mg / kg, iyo 800 mg / kg ee guanylacetic acid quudinta broiler waxay muujisay koror weyn oo celcelis ahaan korodhka miisaanka maalinlaha ah marka loo eego kooxda xakamaynta.Natiijooyinka ugu wanaagsan ayaa la gaaray markii heerarka isku-darka ay ahaayeen 600 iyo 800 mg/kg.

Si loo darso saamaynta guanylacetic acid ee tayada shahwada ee diiqu, 20 28 wiiggii diiqii jiray ayaa la doortay si ay u quudiyaan cunto ka kooban 0%, 0.06%, 0.12%, iyo 0.18% guanylacetic acid.Natiijooyinka cilmi-baarista ayaa lagu ogaaday in lagu daro 0.12% guanylacetic acid ee cuntada ayaa si weyn u kordhisay tirada shahwada, xoojinta shahwada, iyo dhaqdhaqaaqa shahwada ee diiqusha, taas oo muujinaysa in lagu daro guanylacetic acid cuntada ay si wax ku ool ah u wanaajin karto tayada shahwada.Ku dar 0.0314%, 0.0628%, 0.0942%, iyo 0.1256% guanylacetic acid quudinta maalinlaha ah ee broilers, oo dhig laba kooxood oo kontorool ah (kooxda xakamaynta 1 waa quudin ku salaysan dhirta iyada oo aan lagu darin wax walax ah, iyo kooxda xakamaynta 2 waa quudin leh cuntada kalluunka lagu daray).Lixda kooxood ee kor ku xusan ee quudinta maalinlaha ah waxay leeyihiin heer isku mid ah tamarta iyo macdanta.

Natiijooyinka tijaabada ah waxay muujinayaan in heerka korodhka miisaanka afarta kooxood ee guanylacetic acid lagu daray iyo kooxda kantaroolka 2 ay ka sarreeyaan kuwa kooxda kantaroolka 1, Kooxda xakamaynta 2 waxay lahayd saameynta ugu fiican ee miisaanka, oo ay ku xigto 0.0942% guanylacetic acid;Kooxda xakamaynta 2 waxay lahayd walxaha ugu fiican ee miisaanka miisaanka, oo ay ku xigto 0.1256% kooxda guanylacetic acid.

Codsiga digaaga:

Ku darida 800 mg/kg, 1600 mg/kg, 4000 mg/kg, and 8000 mg/kg ofguanylacetic acidquudinta maalinlaha ah ee broilers waxay muujisay in lagu daro 800-4000 mg / kg ee guanylacetic acid quudinta waxay si weyn u kordhisay korodhka miisaanka maalinlaha ah ee broilers, waxay hoos u dhigtay quudinta miisaanka miisaanka broilers ee 22-42 maalmood da'da.Ku darista 8000 mg / kg ee guanylacetic acid waxay hagaajisay tilmaamayaasha biochemical ee serum sida nitrogen urea, tilmaamayaasha joogtada ah ee dhiigga, iyo wadarta bilirubin Ma jirin wax saameyn ah oo muhiim ah oo ku saabsan tilmaamayaasha xubnaha waaweyn, taas oo muujinaysa in lagu daro 8000 mg / kg guanylacetic acid quudinta maalinlaha ah ee broilers. waa loo dulqaadan karaa.Ku darida 200 mg / kg, 400 mg / kg, 600 mg / kg, iyo 800 mg / kg ee guanylacetic acid quudinta broiler waxay muujisay koror weyn oo celcelis ahaan korodhka miisaanka maalinlaha ah marka loo eego kooxda xakamaynta.Natiijooyinka ugu wanaagsan ayaa la gaaray markii heerarka isku-darka ay ahaayeen 600 iyo 800 mg/kg.

Si loo darso saamaynta guanylacetic acid ee tayada shahwada ee diiqu, 20 28 wiiggii diiqii jiray ayaa la doortay si ay u quudiyaan cunto ka kooban 0%, 0.06%, 0.12%, iyo 0.18% guanylacetic acid.Natiijooyinka cilmi-baarista ayaa lagu ogaaday in lagu daro 0.12% guanylacetic acid ee cuntada ayaa si weyn u kordhisay tirada shahwada, xoojinta shahwada, iyo dhaqdhaqaaqa shahwada ee diiqusha, taas oo muujinaysa in lagu daro guanylacetic acid cuntada ay si wax ku ool ah u wanaajin karto tayada shahwada.Ku dar 0.0314%, 0.0628%, 0.0942%, iyo 0.1256% guanylacetic acid quudinta maalinlaha ah ee broilers, oo dhig laba kooxood oo kontorool ah (kooxda xakamaynta 1 waa quudin ku salaysan dhirta iyada oo aan lagu darin wax walax ah, iyo kooxda xakamaynta 2 waa quudin leh cuntada kalluunka lagu daray).Lixda kooxood ee kor ku xusan ee quudinta maalinlaha ah waxay leeyihiin heer isku mid ah tamarta iyo macdanta.Natiijooyinka tijaabada ah waxay muujinayaan in heerka korodhka miisaanka afarta kooxood ee guanylacetic acid lagu daray iyo kooxda kantaroolka 2 ay ka sarreeyaan kuwa kooxda kantaroolka 1, Kooxda xakamaynta 2 waxay lahayd saamaynta ugu fiican ee miisaanka, oo ay ku xigto 0.0942%guanylacetic acidkoox;Kooxda xakamaynta 2 waxay lahayd walxaha ugu fiican ee miisaanka miisaanka, oo ay ku xigto 0.1256% kooxda guanylacetic acid.