Tributyrin Bakeng sa Bophelo bo Botle ba Bowel, Papiso le Sodium Butyrate

Tributyrin e hlahisoa ke k'hamphani ea Efine bE itšetlehile ka litšobotsi tsa 'mele le taolo ea phepo e nepahetseng ea lipatlisiso tsa theknoloji ea intestinal mucosa ea mofuta o mocha oa lihlahisoa tsa tlhokomelo ea bophelo bo botle ba liphoofolo, e ka tlatsa ka potlako phepo e nepahetseng ea mucosa ea mala, ho khothalletsa nts'etsopele le ho hōla ha mala, ho lokisa mefuta eohle ea khatello ea kelello e bakoang ke ho senyeha ha mala a mala, ho sireletsa bophelo bo botle ba mala, ho matlafatsa ts'ebetso ea tšilo ea mala le ho monya, e ka thibela ka katleho necrotizing enteritis le ho ntlafatsa ts'ebetso ea tlhahiso ea mehlape le likhoho.

Lebitso la sehlahisoa

tributyrin

Ponahalo

Phofo e tšoeu

Likarolo tse ka sehloohong

Tributyrin , Glycerin monobutyrate moemeli

monko

Ha ho monko o khethehileng

likaroloana

100%fetisa20 Tlhahlobo ea sepheo

Tahlehelo ka ho omisa

≤10%

Tlhaloso ea ho paka

Net boima ba 25kg

Mokhoa oa ts'ebetso ea asiti ea butyric

Bongata ba li-acid tse mafura tse hlokoang ke liphoofolo tse ruiloeng le likhoho li ka fumanoa lijong (phepelo), empa li-acid tse ling tse khutšoane tsa mafura (joalo ka butyric acid) ha li fumanehe ka kakaretso ho tsoa ho fepa.Short-chain fatty acids, haholo butyric acid, e bapala karolo ea bohlokoa ho boloka bophelo bo botle ba mala a liphoofolo le likhoho, ho kenyelletsa:

1.Butyric acid ke mohloli o potlakileng oa matla bakeng sa ho lokisoa ha kotsi ea mala a mehlape le likhoho, e ka bola ka potlako le ho lokolla matla, e khothalletsa kholo ea lera la chorionic, le ho ntlafatsa ts'ebetso ea mokoallo oa 'mele.

2.Butyric acid e ka fokotsa litaba tsa oksijene ka har'a pampiri ea mala, ea thibela ho ikatisa ha libaktheria tse kotsi tse jang oksijene, 'me ea khothalletsa ho ata ha libaktheria tse molemo tse kang lactic acid bacteria.

3.Butyric acid e ka kenya tšebetsong limolek'hule tse sebetsang tsa lisele tsa 'mele tsa mala le ho ntlafatsa ts'ireletso ea mala a mala.

Mehloli le papiso ea asiti ea butyric lijong

 

Ts'ebetso ea metabolic ea asiti ea butyric ho liphoofolo

Ho sebetsa hantle le litšobotsi

1.E le mafura a ka sehloohong a phefumolohang bakeng sa lisele tsa intestinal epithelial, e ka fana ka matla ka potlako ho lisele tsa intestinal epithelial, ka katleho e khothalletsa ho hōla ha lisele tsa mala a mala, ho kenya letsoho tlhokomelong le tokisong ea mala a mala, le ho boloka botšepehi le ts'ebetso ea lisele tsa mala a mala.

2.Bophahamo ba intestinal villus bo ile ba eketseha,fokotsehile botebo ba crypt , ntlafatsakaro-karolelano ea bophahamo ba intestinal villus ho botebo ba crypt , lentlafatsasebopeho sa sebopeho sa mala a manyane.

3.Fokotsa pH ea mala, thibela kholo ea libaktheria tsa pathogenic tse kang Escherichia coli, Salmonella le Clostridium perfringens, ho khothalletsa ho ata ha libaktheria tse molemo tsa lactic acid baktheria, ho laola ho leka-lekana ha mala a liphoofolo le likhoho.

4.Khothaletsa secretion ea li-antibodies le lisele tsa 'mele tsa ho itšireletsa mafung tsa mucosa ea mala, ho matlafatsa matla a ho itšireletsa mafung le likhoho, ho fokotsa ho ruruha ha mala le mafu a mang..

butyrin

Setšoantšo sa 1Liphello tsa triglyceride le Coated sodium butyrate molemong oa letsatsi le letsatsi oa likhoho tse masiba a masoeu.

Liphetho li bonts'itse hore ha ho bapisoa le sehlopha sa taolo, phaello ea letsatsi le letsatsi ea likhoho tse nang le masiba a masoeu e eketsehile haholo ka ho eketsatributyrin, 'me sephetho se ne se le betere ho feta sa sehlopha sa sodium butyrate se koahetsoeng

bapisa sehlopha

setšoantšo sa 2 Liphello tsa triglyceride le sodium butyrate e koahetsoeng ka mala a microflora ea likhoho.

Liphetho li bontšitse hore ha li bapisoa le sehlopha sa taolo, ho eketsaTributyrin e ka fokotsa haholo palo ea escherichia coli ka maleng a likhoho, 'me ea eketsa haholo palo ea libaktheria tsa lactic acid,' me phello e ne e le betere ho feta ea sehlopha sa sodium butyrate se koahetsoeng.

Liphello tsa triglyceride le sodium butyrate kholong le sekhahla sa Lets'ollo la Piglet

Liphello li bontšitse hore, ho tšoana le liphello tsa lithibela-mafu, triglyceride e ka eketsa haholo phaello ea letsatsi le letsatsi ea likolobe tsa likolobe ka 11% ~ 14%, ea fokotsa karolelano ea lijo le nama ka 0.13 ~ 0.15, 'me ea fokotsa haholo sekhahla sa letšollo la likolobe. e ne e le betere ho feta sehlopha sa sodium butyrate.

Khothaletsa tšebeliso:

Fepa phoofolo Khothaletsa chelete e eketsehileng (48% phofo) Khothaletsa chelete e eketsehileng (90% metsi)
Khoho ea likhoho

500-1000g/T

200-400g/T

Meruo

500-1500g/T

200-600g/T

Metsing

500-1000g/T

200-400g/T

Ruminate

500-2000g/T

200-800g/T


Nako ea poso: Mar-16-2022