M'zaka zaposachedwa, "maphwando opangira" ochulukirachulukira adatuluka mumakampani osamalira khungu.Sakumveranso zotsatsa komanso olemba mabulogu akubzala udzu mwakufuna kwawo, koma amaphunzira ndikumvetsetsa zopangira zosamalira khungu pawokha, kuti asankhe mankhwala osamalira khungu oyenera iwo.

Ndi mpikisano womwe ukukulirakulira pakati pa osamalira khungu, ochulukirachulukira akutsata "zowonjezera" kuti "zosakaniza zothandiza".Zosakaniza zosamalira khungu zomwe zimathandizidwa ndi ukadaulo wakuda zimachulukirachulukira, zomwe zimapangitsa kuti "chipani choyambirira chimayang'ana zosakaniza, ndipo gawo lalikulu lazinthu limayang'ana ukadaulo".

Samalani zatsopano zamtundu wamutu wapakhomo ndi wakunja, ndikuwona kuti mitundu iyi yamutu ikufulumizitsa kukweza kwa zida zopangira ndi ukadaulo, kuti zinthu zatsopano zitha kukopa ogula ambiri, ndipo ukadaulo watsopano ukhoza kutsogolera makampaniwo kulowa njira yatsopano. .Kukwera kwa chipani cha sayansi ndi ukadaulo kwenikweni ndi chizindikiro cha kulimbikira kwamkati kwa akatswiri odzola mafuta.

Lipoti la 2025 pakugwiritsa ntchito sayansi ndi ukadaulo pantchito yokongola likuwonetsa kuti kuphatikiza kukongola ndi ukadaulo kukukula mwakuya, ndipo ukadaulo wotsogola wozikidwa pa sayansi yachilengedwe upitiliza kuthandiza R & D ndikupanga zatsopano. zinthu zokongola.Makampani okongola omwe athandizidwa ndi sayansi ndiukadaulo adzadzetsa kuphulika, ndipo msika ufika pafupifupi 1 thililiyoni yuan pofika 2025.

 

Kafukufuku ndi chitukuko cha kukonzekera kwa mankhwala a nano kwakhala njira yodziwika bwino yazachipatala ndi zamankhwala padziko lonse lapansi, komanso kugwiritsa ntchito njira zamakono za liposomes ndi vesiclespharmaceutical kukonzekera matekinoloje monga nano carrier technology mu zodzoladzola zogwira ntchito zalimbikitsidwa ndikuthandizidwa ndi boma. .

Chifukwa epidermis yaumunthu imakhala yovuta kulowa, zakudya zimakhala zovuta kufika pamtunda wakuya wa khungu, zomwe zimakhudza kwambiri kugwiritsa ntchito mankhwala osamalira khungu.Ukadaulo wa Nanocarrier udatulukira monga momwe nthawi zimafunikira, makamaka kuthetsa mavuto omwe akuwatsogolera, kutulutsa pang'onopang'ono kwa mankhwala, kuyamwa kwa transdermal ndi zina zotero.The nanocarriers ambiri ntchito monga liposomes, hydrogel onyamula, micelles, microcapsules, madzi crystal systems, supramolecules, etc.

Kugwiritsiridwa ntchito kwa nanocarriers kuti apereke zosakaniza zosamalira khungu kumalo okhudzidwa ndi khungu ndi maselo kupyolera mu kubereka komwe kumayang'aniridwa ndi khungu, kumasulidwa pang'onopang'ono komanso kwautali, kuthetsa bwino vuto laukadaulo lazodzoladzola zachikhalidwe zomwe zimakhala zovuta kuyamwa pakhungu.Nanocarriers alinso ndi ntchito yokonza solubility ndi madzi dispersibility wa zosakaniza zinchito za zodzoladzola insoluble, kuwongolera kukhazikika kwa kuwala tcheru ndi kutentha tcheru zosakaniza zinchito, ndi kupititsa patsogolo kugwirizana kwa zosakaniza zinchito.

Kumayambiriro kwa 1965, akatswiri a maphunziro a ku Britain Bangham ndi Standish anapeza kuti phospholipids amatha kupanga ma vesicles (micelle) m'madzi kudzera mu microscopy ya electron, ndipo anawatcha kuti liposomes.Ichi chinakhala chimodzi mwazinthu zazikulu zomwe zapezedwa pazamankhwala m'zaka za zana la 20.

Ngale pa korona wa nanocarriers - liposomes

Popeza mapangidwe achilengedwe a plasma membrane ndi phospholipid bilayer membrane, ma liposomes ali ndi mawonekedwe ofanana ndi ma cell achilengedwe, motero amakhala ndi biocompatibility yabwino, chifukwa chake amatchedwanso "biofilm yopangira".Ma Liposomes amagwiritsa ntchito kuyanjana uku kuti akwaniritse zoperekera mankhwala omwe akuwaganizira kapena oyenera.Ma liposomes abwino ayenera kukhala ndi histocompatibility yabwino, kawopsedwe kakang'ono, kaphatikizidwe kabwino ka mankhwala ndi kutulutsa mphamvu.

Monga dzina limatanthawuzira, chigawo chachikulu cha liposomes ndi "lipids".Ma liposomes omwe amapezeka kwambiri nthawi zambiri amapangidwa ndi ma phospholipids ndi cholesterol, omwe ndi zinthu zomwe zimakhalapo m'zamoyo, zimagwirizana bwino ndi minofu ndipo sizikhala ndi chitetezo chamthupi.

Makonda zopangira chiwembu cha liposomes

Dzina lamalonda lazinthu zopangira: chitetezo ku ukalamba liposome

Compound encapsulation scheme: liposome + retinol + astaxanthin + coenzyme Q10

Kugwiritsa ntchito bwino kwazinthu zopangira: zolimba komanso zosagwirizana ndi makwinya

Kugwiritsa ntchito kovomerezeka: 5% - 10%

Zogwiritsidwa ntchito: Essence madzi, essence, chigoba kumaso, gel osakaniza, mafuta odzola, zonona