Lilemong tsa morao tjena, "mekhatlo ea metsoako" e ntse e eketseha indastering ea tlhokomelo ea letlalo.Ha ba sa mamela lipapatso le li-bloggers tse jalang joang ka boithatelo, empa ba ithuta le ho utloisisa metsoako e sebetsang ea lihlahisoa tsa tlhokomelo ea letlalo ka bobona, e le ho khetha lihlahisoa tsa tlhokomelo ea letlalo tse ba loketseng.

Ka tlholisano e ntseng e eketseha e matla har'a lihlahisoa tsa tlhokomelo ea letlalo, lihlahisoa tse ngata li ntse li phehella "lisebelisoa tse ngata" ho "lisebelisoa tse molemo".Lisebelisoa tsa tlhokomelo ea letlalo tse tšehetsoeng ke thekenoloji ea batho ba batšo li ntse li ratoa le ho feta, ho theha boemo ba hore "mokhatlo oa mantlha oa motsoako o sheba metsoako, 'me mokha o moholo oa motsoako o sheba theknoloji".

Ela hloko lihlahisoa tse ncha tsa lihlooho tsa lihlooho tsa malapeng le tsa linaheng tse ling, 'me u fumane hore lihlahisoa tsena tsa hlooho li potlakisa ntlafatso ea thepa e tala le theknoloji, e le hore lihlahisoa tse ncha li ka hohela bareki ba bangata,' me theknoloji e ncha e ka etsa hore indasteri e kenelle pina e ncha. .Ho phahama ha mokha oa mahlale le thekenoloji ha e le hantle ke sesupo sa tšubuhlellano e matla ea ka hare ho basebetsi ba litlolo.

Tlaleho ea pono ea 2025 mabapi le ts'ebeliso ea mahlale le thekenoloji indastering ea botle e bonts'a hore kopanyo ea botle le thekenoloji e ntse e tsoela pele ka botebo, 'me theknoloji ea morao-rao e thehiloeng ho saense ea baeloji e tla tsoelapele ho thusa R&D le tlhahiso ea boqapi. lihlahisoa tsa botle.Indasteri ea botle e matlafalitsoeng ke mahlale le thekenoloji e tla baka ho phatloha, 'me sekhahla sa mmaraka se tla fihla ho li-yuan tse ka bang 1 trillion ka 2025.

 

Patlisiso le nts'etsopele ea litokisetso tsa meriana ea nano e fetohile tataiso e ka sehloohong ea sechaba sa hajoale sa bongaka le meriana ea machabeng, 'me ts'ebeliso ea mekhoa e mecha ea liposomes le mahlale a ho itokisa a vesiclespharmaceutical joalo ka theknoloji ea nano carrier ho litlolo tse sebetsang e khothalelitsoe le ho tšehetsoa ke mmuso. .

Hobane epidermis ea motho e thata ho kenella, phepo e nepahetseng e thata ho fihla karolong e tebileng ea letlalo, e amang haholo phello ea tšebeliso ea lihlahisoa tsa tlhokomelo ea letlalo.Theknoloji ea Nanocarrier e hlahile kamoo linako li hlokang kateng, haholo-holo ho rarolla mathata a phano e lebisitsoeng, ho lokolloa butle ha lithethefatsi, ho monya transdermal joalo-joalo.Li-nanocarriers tse sebelisoang hangata li kenyelletsa liposomes, bajari ba hydrogel, micelles, microcapsules, litsamaiso tsa kristale tsa metsi, li-supramolecules, jj.

Tšebeliso ea li-nanocarriers ho fana ka lisebelisoa tsa ts'ebetso ea tlhokomelo ea letlalo libakeng tsa tlhokomelo ea letlalo le liseleng ka ho fana ka letlalo le lebisitsoeng, ho lokolloa butle-butle le nako e telele, ho rarolla bothata bo tloaelehileng ba indasteri ea litlolo tsa setso tse sebetsang hantle tseo ho leng thata ho li amohela ka letlalo.Li-nanocarriers li boetse li na le mesebetsi ea ho ntlafatsa ho qhibiliha le ho qhalakanngoa ha metsi a metsoako e sebetsang ea litlolo tse sa qhibiliheeng, ho ntlafatsa botsitso ba lisebelisoa tse sebetsang ka mokhoa o bonolo le tse nang le mocheso, le ho ntlafatsa ho lumellana ha metsoako e sebetsang.

Ho tloha ka 1965, litsebi tsa Brithani Bangham le Standish li fumane hore phospholipids e ka iketsetsa li-bilayer vesicles (micelle) metsing ka microscope ea elektronike, 'me ea li reha liposomes.Ena e bile e ’ngoe ea litšibollo tse khōlō lefapheng la meriana lekholong la bo20 la lilemo.

Pearl e holim'a moqhaka oa li-nanocarriers -- liposomes

Kaha sebopeho sa motheo sa lera la plasma ea likokoana-hloko e boetse e le phospholipid bilayer membrane, liposomes li na le sebopeho se tšoanang le lisele tsa likokoana-hloko, kahoo li na le biocompatibility e ntle, kahoo li boetse li bitsoa "biofilm ea maiketsetso".Liposomes li sebelisa tumellano ena ho fihlela phano ea lithethefatsi e lebisitsoeng kapa e sebetsang hantle.Liposomes tse loketseng li lokela ho ba le histocompatibility e ntle, chefo e tlase, ho koaheloa ha lithethefatsi tse loketseng le matla a ho lokolla.

Joalokaha lebitso le bolela, karolo ea mantlha ea liposomes ke "lipids".Liposomes tse tloaelehileng hangata li entsoe ka phospholipids le k'holeseterole, e leng lintho tsa tlhaho tse teng linthong tse phelang, tse lumellanang hantle le lisele ebile ha li na immunogenic.

Morero o hlophisitsoeng oa thepa e tala bakeng sa liposomes

Lebitso la khoebo la thepa e tala: ts'ireletso khahlano le botsofali ba liposome

Sekema sa motsoako oa encapsulation: liposome + retinol + astaxanthin + coenzyme Q10

Tšebeliso e sebetsang ea thepa e tala: e kopana ebile e hanyetsa mats'oenyeho

Tšebeliso e khothalletsoang: 5% - 10%

Lihlahisoa tse sebetsang: Metsi a bohlokoa, motsoako, mask a sefahleho, gel, lotion, tranelate