Pono nā ʻano ʻē aʻe i nā lāʻau antibiotic ma muli o ka pāpā ʻana i ka hoʻohana ʻana i kēia mau lāʻau lapaʻau i mea hoʻoikaika ulu i ka hana holoholona meaʻai.ʻIke ʻia ʻo Tributyrin i ka hoʻomaikaʻi ʻana i ka ulu ʻana o ka puaʻa, ʻoiai me nā pae like ʻole o ka pono.

I kēia manawa, liʻiliʻi loa ka ʻike e pili ana i kona hopena ma ka ʻōpū microbiota haku.Ma kēia noiʻi ʻana, ua noiʻi mākou i nā loli microbiota o nā puaʻa e loaʻa ana, i ka weaning, 0.2% tributyrin i hoʻohui ʻia i kā lākou ʻai basal.

Loaʻa i ka pūʻulu Tributyrin kahi hiki ke hoʻonui ʻia no ka metabolism ikehu a me ka hiki ke hoʻemi ʻia no ka metabolism carbohydrate.I ka hopena, ua hōʻike kā mākou hopena e hiki i ka tributyrin ke hoʻoikaika i nā loli i nā kaiāulu microbial gut, hiki ke kōkua i ka hoʻomaikaʻi ʻana i ka hana holoholona ma hope o ka weaning.

Nā hopena o ka Tributyrin ma nā hoʻololi ʻana o Gut Microbiota e pili ana i nā hana o nā puaʻa weaning.

Nā Kūlana Huahana

ʻO Tributyrin (ʻo ia hoʻi ka inoa ʻo Glyceryl tributyrate; Glycerol tributyrate; Glycery tributyrate; propane-1,2,3-triyl tributanoate) ， ʻo ia ke ʻano o nā kaulahao pōkole momona momona ester.

CAS RN: 60-01-5

EINECS No.: 200-451-5

Hoʻohālikelike: C15H26O6

FW: 302.36

ʻAno: He wai ʻaila keʻokeʻo a melemele me ka ʻala momona iki.

Hiki ke hoʻoheheʻe ʻia: hiki ke hoʻoheheʻe ʻia i ka ethanol, chloroform a me ka etera, hiki ʻole ke hoʻoheheʻe ʻia i ka wai (0.010 % ).

Noho ʻia: 24 mau mahina

Pūʻolo: 25KG / ʻeke

Ka mālama ʻana: Hoʻopaʻa ʻia ma nā wahi maloʻo a me nā ventilated

Tributyrinhe triglyceride i loaʻa i ʻekolu mau molekala butyrate i hoʻoheheʻe ʻia i glycerol, hoʻonui i ka nui o ka butyrate ma hope o ka hydrolyzation e nā lipases pancreatic.

Nā hiʻohiʻona o Tributyrin
He hanauna hou o ka butyrate-glycerol ester o ka waikawa butyric.
100% bypass ʻōpū.
Hāʻawi i nā waikawa butyric i loko o ka ʻōpū liʻiliʻi, ʻaʻole pono e uhi ʻia.
Loaʻa maoli i ka waiū a me ka meli.

Hoʻohālikelike ma waena o Tributyrin & Butyrate Salt

ʻO ka hapalua o ke ola o ka waikawa butyric he 6 mau minuke.He paʻakikī ka Butyrate e hiki i nā ʻiʻo a me nā ʻāpana ʻē aʻe ma waho o ka ʻōpū i lawelawe ʻia ma ke ʻano o ka butyric acid a i ʻole butyrate. Akā naʻe, ʻo ka hapalua o ke ola o ka tributyrin he 40min, a hiki ke mālama ʻia ka ʻike plasma o butyrate ma luna o 0.1mM no 0.5-4h ma o ka waha. .

Mechanism & Hiʻona

Mea hoolako ikehu

E like me ka mea i ʻike ʻia, ʻo ka waikawa butyric kahi momona momona pōkole ʻo ia ke kumu nui o ka ikehu o nā cell epithelial intestinal.Eia naʻe, hāʻawi ka tributyrin i ka waiwai nui o ka butyric acid i hoʻohālikelike ʻia me nā huahana butyrate ʻē aʻe.

Palekana ʻōpū

Hoʻoikaika ʻo Tributyrin i ka hoʻonui ʻana a me ka hoʻokaʻawale ʻana o nā cell epithelial mucosal intestinal, hoʻoponopono i ka mucosa i hoʻopōʻino ʻia, a hoʻonui i ka ʻili no ka lawe ʻana i nā meaʻai.

Hoʻoikaika ʻo Tributyrin i ka hōʻike ʻana i nā protein junction paʻa i loko o ka ʻōpū, mālama i nā hui paʻa ma waena o nā cell, pale i nā macromolecules e like me ka bacteria a me nā toxins mai ke komo ʻana i ke kino, a mālama i ka hana pale kino o ka ʻōpū.

►Hoʻoikaika ʻo Tributyrin i ka huna ʻana o ka mucin (Muc) a hoʻoikaika i ka hana pale kemika o ka ʻōpū.

Hoʻonui ʻia ka helu ola

Hiki i ka Tributyrin ke hoʻoikaika i ka synthesis o hemoglobin, hoʻomaikaʻi i ka hiki o ka lawe ʻana i ka oxygen, hoʻoikaika i ka ʻōnaehana kākoʻo ola endogenous, a hiki iā ia ke hoʻomaikaʻi i ka hana o ka mitochondria a hoʻoikaika i ka synthesis o ATP, ka mea ikehu e alakaʻi ai i ka hana ola.i mea e hoʻomaikaʻi ai i ka helu ola a i ʻole nā ​​holoholona.

Anti-Inflammatory & Antibacteria

►Ma ke kāohi ʻana i ka hana o NF-Kb, TNF-α a me TLR, hiki i ka Tributyrin ke hoʻohaʻahaʻa i ka pōʻino inflammatory.

Hoʻolaha ʻo Tributyrin i ka hōʻike ʻana o nā peptides pale endogenous, hiki ke pale i ka pathogen a me ka maʻi maʻi ākea.