Ubundi buryo bwo kuvura antibiyotike burasabwa kubera kubuzwa gukoresha iyi miti nkiterambere ryiterambere ry’umusaruro w’amatungo.Tributyrin isa nkaho igira uruhare mukuzamura imikorere yo gukura kwingurube, nubwo zifite imbaraga zitandukanye.

Kugeza ubu, bike cyane bizwi ku ngaruka zabyo ku mikorobe ya mikorobe.Muri ubu bushakashatsi, twasesenguye amara ya microbiota yinda yingurube yakira, mugihe cyo konka, 0.2% tributyrin yongewe kumirire yabo yibanze.

Itsinda rya Tributyrin ryari rifite imbaraga zongerewe imbaraga zo guhinduranya ingufu no kugabanya ubushobozi bwa metabolisme ya karubone.Mu gusoza, ibisubizo byacu byagaragaje ko tributyrine ishobora guteza imbere impinduka ziterwa na mikorobe zo mu nda, zishobora kugira uruhare mu kuzamura imikorere y’inyamaswa nyuma yo konka.

Ingaruka za Tributyrin kuri Gut Microbiota Impinduka zijyanye n'imikorere y'ingurube

Ibipimo byibicuruzwa

Tributyrin (nanone yitwa Glyceryl tributyrate; Glycerol tributyrate; Glycery tributyrate; propane-1,2,3-triyl tributanoate) ， ni ubwoko bwurunigi rugufi rwa acide acide.

CAS RN: 60-01-5

EINECS No.: 200-451-5

Ibisanzwe: C15H26O6

FW: 302.36

Kugaragara: Ni umweru wumuhondo amavuta yumuhondo hamwe nimpumuro nziza.

Gukemura: gushonga muri Ethanol, chloroform na ether, bigoye gushonga mumazi (0.010%).

Ubuzima bwa Shelf: Amezi 24

Ipaki: 25KG / Umufuka

Ububiko: Bifunze ahantu humye kandi bihumeka

Tributyrinni triglyceride irimo molekile eshatu za butyrate zegeranijwe na glycerol, zongera ingufu za butyrate nyuma ya hydrolyzation na lipase pancreatic lipase.

Ibiranga Tributyrin
Igisekuru gishya cya butyrate-glycerol ester ya aside ya butyric.
100% kurenga igifu.
Gutanga aside irike mu mara mato, ntibikenewe gutwikirwa.
Mubisanzwe uboneka mumata n'ubuki.

Kugereranya Hagati ya Tributyrin & Butyrate Umunyu

we igice cya kabiri cya acide butyric ni iminota 6.Butyrate iragoye kugera ku zindi ngingo ningingo zo hanze y amara zitangwa muburyo bwa acide butyric cyangwa butyrate.Nyamara igice cya kabiri cyubuzima bwa tributyrin ni 40min, kandi plasma yibanze ya butyrate irashobora kuguma hejuru ya 0.1mM kuri 0.5-4h mukanwa .

Imikorere & Ibiranga

Utanga ingufu

Nkuko bizwi, acide ya butyric ni acide ya fatty acide nini nisoko nyamukuru yingirabuzimafatizo zo mu mara.Birenze 70% byingufu zo gukura kwingirangingo zo munda zitangwa na acide butyric.Nyamara, tributyrin itanga igifu kinini kirekura aside butyric ugereranije nibindi bicuruzwa bya butyrate.

Kurinda Igifu

►Tributyrine iteza ikwirakwizwa no gutandukanya ingirabuzimafatizo zo mu mara epithelial selile, igasana mucosa yangiritse, ikanagura ubuso bwo gukuramo intungamubiri.

►Tributyrin iteza imbere poroteyine zifatika zifata mu nda, ikomeza guhuza cyane hagati ya selile, ikabuza macromolecules nka bagiteri n'uburozi kwinjira mu mubiri, kandi igakomeza imikorere ya barrière physique yo munda.

►Tributyrin iteza imbere ururenda rwa mucin (Muc) kandi ikomeza imikorere ya barrière chimique.

Igipimo cyo Kurokoka Cyatejwe imbere

Tributyrin irashobora guteza imbere synthesis ya hemoglobine, ikongerera ubushobozi bwo gutwara ogisijeni, igashimangira sisitemu yo gufasha ubuzima bwa endogenous, kandi ishobora guteza imbere imikorere ya mitochondriya kandi igateza imbere synthesis ya ATP, imbaraga zitwara ibikorwa byubuzima.kugirango uzamure igipimo cyo kubaho cyangwa inyamaswa.

Kurwanya Inflammatory & Antibacteria

YKubuza ibikorwa bya NF-Kb, TNF-α na TLR, Tributyrin irashobora kugabanya ibyangiritse.

►Tributyrin iteza imbere imvugo ya peptide ya endogenous defence, ishobora kongera kwanduza virusi na virusi.