Iindlela ezizezinye kunyango lwe-antibiotics ziyafuneka ngenxa yokuvalwa kokusetyenziswa kwala machiza njengabakhuthazi bokukhula kwimveliso yokutya yezilwanyana.I-Tributyrin ibonakala idlala indima ekuphuculeni ukukhula kweehagu, nangona imigangatho eyahlukeneyo yokusebenza.

Ukuza kuthi ga ngoku, kuncinci kakhulu okwaziwayo malunga neziphumo zayo kukwakheka kwe-gut microbiota.Kolu phononongo, siphande utshintsho lwe-gut microbiota yeehagu ezifumanayo, ekulumleni, i-0.2% ye-tributyrin eyongezwe kwi-basal diet.

Iqela le-Tributyrin linamandla okwandisa amandla e-metabolism kunye nokuncitshiswa kwesakhono se-carbohydrate metabolism.Ukuqukumbela, iziphumo zethu zibonise ukuba i-tributyrin inokukhuthaza utshintsho kuluntu lwe-microbial yamathumbu, olunokuthi lube negalelo ekuphuculeni ukusebenza kwezilwanyana emva kokulunyulwa.

Iimpembelelo ze-Tributyrin kwiGut Microbiota Shifts eziNxulumene neMisebenzi yokulunyulwa kwamantshontsho eehagu

Iiparamitha zeMveliso

I-Tributyrin (ekwabizwa ngokuba yi-Glyceryl tributyrate; i-Glycerol tributyrate; i-Glycery tributyrate; i-propane-1,2,3-triyl tributanoate), luhlobo lwetsheyini emfutshane enamafutha e-ester.

I-CAS RN: 60-01-5

I-EINECS No.: 200-451-5

Ifomula: C15H26O6

FW: 302.36

Imbonakalo: Kumhlophe ukuya kulwelo olunamafutha atyheli kunye nevumba elimnandi kancinane.

I-Solubility: i-soluble kwi-ethanol, i-chloroform kunye ne-ether, i-soluble enganyibiliki emanzini (0.010%).

Ubomi beShelf: Iinyanga ezingama-24

Iphakheji: 25KG / Bag

Ugcino: Kuvalwa kwiindawo ezomileyo nezingena umoya

I-Tributyrinyi-triglyceride equlethe iimolekyuli ezintathu ze-butyrate esterified kwi-glycerol, ikwandisa i-butyrate concentrations emva kwe-hydrolyzation yi-pancreatic lipases.

Iimpawu zeTributyrin
Isizukulwana esitsha se-butyrate-glycerol ester ye-butyric acid.
100% yi-bypass isisu.
Ukuhambisa i-butyric acids kumathumbu amancinci, akufuneki ukuba igqunywe.
Ngokwendalo ifumaneka ebisi nasebusini.

Ukuthelekisa phakathi kweTributyrin kunye neTyuwa yeButyrate

yena isiqingatha-ubomi butyric acid yimizuzu emi-6.I-Butyrate inzima ukufikelela kwezinye izicubu kunye nezitho ezingaphandle kwamathumbu alawulwa ngendlela ye-butyric acid okanye i-butyrate.Nangona kunjalo i-half-life of tributyrin yi-40min, kwaye i-plasma concentration ye-butyrate ingagcinwa ngaphezu kwe-0.1mM ye-0.5-4h ngomlomo womlomo. .

Inkqubo & Iimpawu

Umboneleli wamandla

Njengoko kwaziwa, i-asidi ye-butyric yi-acid-chain fatty acid engowona mthombo wamandla kwiiseli ze-epithelial zamathumbu.Ngaphezu kwe-70% yamandla okukhula kweeseli ze-epithelial zamathumbu zibonelelwa yi-butyric acid.Nangona kunjalo, i-tributyrin ibonelela ngelona xabiso liphezulu le-butyric acid xa lithelekiswa nezinye iimveliso ze-butyrate.

Ukukhuselwa kwamathumbu

►I-Tributyrin ikhuthaza ukwanda kunye nokuhlukana kweeseli ze-epithelial ze-intestinal mucosal, ukulungisa i-mucosa eyonakeleyo, kwaye yandisa indawo ephezulu yokufumana izondlo.

►I-Tributyrin ikhuthaza ukubonakaliswa kweeprotheyini ezidibeneyo emathunjini, igcina imidibaniso eqinile phakathi kweeseli, ikhusela ama-macromolecules afana neebhaktheriya kunye ne-toxins ekungeneni emzimbeni, kwaye igcina umsebenzi wokuthintela umqobo womzimba.

►I-Tributyrin ikhuthaza ukukhutshwa kwe-mucin (Muc) kwaye yomeleza umsebenzi wokuthintela imichiza emathunjini.

Inqanaba lokusinda liphuculwe

I-Tributyrin inokukhuthaza ukuhlanganiswa kwe-hemoglobin, iphucule amandla okuthwala ioksijini, yomeleza inkqubo yenkxaso yobomi engapheliyo, kwaye inokuphucula umsebenzi we-mitochondria kwaye ikhuthaze ukuhlanganiswa kwe-ATP, into yamandla eqhuba umsebenzi wobomi.ukuze kuphuculwe izinga lokusinda okanye izilwanyana.

I-Anti-Inflammatory & Antibacterial

►Ngokuthintela umsebenzi we-NF-Kb, TNF-α kunye ne-TLR, i-Tributyrin inokunciphisa umonakalo ovuthayo.

►I-Tributyrin ikhuthaza ukubonakaliswa kweepeptides ezikhuselayo ezingapheliyo, ezinokuthi zixhathise i-pathogen kunye nentsholongwane ngokubanzi.