Kudingeka izindlela ezihlukile zokwelashwa ngama-antibiotic ngenxa yokuvinjelwa kokusetshenziswa kwale mithi njengabagqugquzeli bokukhula ekukhiqizweni kwezilwane.I-Tributyrin ibonakala idlala indima ekuthuthukiseni ukusebenza kokukhula kwezingulube, nakuba inamazinga ahlukahlukene okusebenza.

Kuze kube manje, kuncane kakhulu okwaziwayo ngemiphumela yako ekwakhiweni kwe-gut microbiota.Kulolu cwaningo, siphenye izinguquko ze-gut microbiota zezingulube ezitholayo, lapho zilunyulwa, i-0.2% ye-tributyrin engezwa ekudleni kwazo okuyisisekelo.

Iqembu le-Tributyrin lalinamandla athuthukisiwe we-metabolism yamandla kanye namandla ancishisiwe we-carbohydrate metabolism.Sengiphetha, imiphumela yethu ibonise ukuthi i-tributyrin ingakhuthaza izinguquko emiphakathini yamagciwane amathumbu, engaba nomthelela ekwenzeni ngcono ukusebenza kwezilwane ngemva kokulunyulwa.

Imithelela ye-Tributyrin ku-Gut Microbiota Shifts Ehlobene Nemisebenzi Yokulunyulwa Kwezingulube

Amapharamitha womkhiqizo

I-Tributyrin (ephinde iqanjwe ngokuthi i-Glyceryl tributyrate; i-Glycerol tributyrate; i-Glycery tributyrate; i-propane-1,2,3-triyl tributanoate), iwuhlobo lweketango elifushane elinamafutha e-ester.

I-CAS RN: 60-01-5

Inombolo ye-EINECS: 200-451-5

Ifomula: C15H26O6

I-FW: 302.36

Ukubukeka: Iwuketshezi olunamafutha olumhlophe kuya kokuphuzi olunephunga elinamafutha amancane.

Ukunyibilika: kuncibilika ku-ethanol, i-chloroform ne-ether, cishe ayincibiliki emanzini ( 0.010 %).

Impilo Yeshelufu: Izinyanga ezingama-24

Iphakheji: 25KG / Isikhwama

Isitoreji: Kuvalwa ezindaweni ezomile nezinomoya

I-Tributyrini-triglyceride equkethe ama-molecule amathathu e-butyrate esterified ku-glycerol, ikhulisa ukugxila kwe-butyrate ngemva kwe-hydrolyzation ngama-pancreatic lipases.

Izimpawu ze-Tributyrin
Isizukulwane esisha se-butyrate-glycerol ester ye-butyric acid.
100% bypass isisu.
Ukuletha ama-asidi e-butyric emathunjini amancane, akudingekile ukumbozwa.
Ngokwemvelo kutholakala obisini noju.

Ukuqhathaniswa Phakathi kwe-Tributyrin ne-Butyrate Salt

I-half-life ye-butyric acid iyimizuzu engu-6.I-Butyrate inzima ukufinyelela ezinye izicubu nezitho ezingaphandle kwamathumbu alawulwa ngendlela ye-butyric acid noma i-butyrate.Nokho-ke isigamu sempilo ye-tributyrin yi-40min, futhi ukuhlushwa kwe-plasma ye-butyrate kungagcinwa ngaphezu kwe-0.1mM ku-0.5-4h ngomlomo womlomo. .

Indlela & Izici

Umphakeli Wamandla

Njengoba kwaziwa kahle, i-butyric acid iyi-short-chain fatty acid ewumthombo wamandla oyinhloko wamaseli e-epithelial yamathumbu. Ngaphezu kuka-70% wamandla okukhula kwamangqamuzana e-epithelial emathunjini ahlinzekwa yi-butyric acid.Kodwa-ke, i-tributyrin inikeza inani eliphakeme kakhulu le-butyric acid elikhipha amathumbu uma liqhathaniswa neminye imikhiqizo ye-butyrate.

Ukuvikela Amathumbu

►I-Tributyrin ikhuthaza ukwanda nokuhlukaniswa kwamaseli e-epithelial e-epithelial yamathumbu emathunjini, ilungisa i-mucosa eyonakele, futhi yandisa indawo engaphezulu ukuze imunce izakhi.

►I-Tributyrin ikhuthaza ukubonakaliswa kwamaprotheni ahlanganayo aqinile emathunjini, igcina ukuhlangana okuqinile phakathi kwamaseli, ivimbela ama-macromolecules afana namagciwane kanye nobuthi ekungeneni emzimbeni, futhi igcina umsebenzi wokuvimbela ngokomzimba wamathumbu.

I-►Tributyrin ikhuthaza ukukhiqizwa kwe-mucin (Muc) futhi iqinisa umsebenzi wokuvimbela amakhemikhali emathunjini.

Izinga Lokusinda Lithuthukisiwe

I-Tributyrin ingathuthukisa ukwakheka kwe-hemoglobin, ithuthukise ikhono lokuthwala umoya-mpilo, iqinise uhlelo lokusekela impilo engapheli, futhi ingathuthukisa umsebenzi we-mitochondria futhi ikhuthaze ukuhlanganiswa kwe-ATP, into yamandla eqhuba umsebenzi wokuphila.ukuze kuthuthukiswe izinga lokusinda noma izilwane.

I-Anti-Inflammatory & Antibacterial

►Ngokuvimbela umsebenzi we-NF-Kb, TNF-α ne-TLR, i-Tributyrin ingadambisa umonakalo ovuthayo.

►I-Tributyrin ikhuthaza ukuvezwa kwama-peptide okuvikela angapheli, angamelana ne-pathogen kanye negciwane ngokubanzi.