aha:γ- aminobutyric acid(GABA)

CAS No.: 56-12-2

Ụdị okwu: 4-Aminobutyric acid;Amonia butyric acid;Pipecolic acid.

1. Mmetụta nke GABA na nri anụmanụ kwesịrị ịdị na-adịgide adịgide n'ime oge ụfọdụ.Nri nri nwere njikọ chiri anya na mmepụta nke anụ ụlọ na anụ ọkụkọ.Dị ka ọrụ omume dị mgbagwoju anya, usoro nhụjuanya nke etiti na-achịkwa nri.Ebe satiety (Ventromedial nucleus nke hypothalamus) na ebe nri (mpụta hypothalamus mpaghara) bụ ndị na-achịkwa anụmanụ.

Ebe isi nri GABA nwere ike ịkpalite nri anụmanụ site na igbochi ọrụ nke satiety center, na-eme ka ikike nri anụmanụ dịkwuo elu.Ọtụtụ ọmụmụ egosila na ịgbanye ụfọdụ dose nke GABA n'ime mpaghara ụbụrụ dị iche iche nke anụmanụ nwere ike ịkwalite nri anụ ọhịa ma nwee mmetụta dabere na dose.Ịtinye GABA na nri bụ isi nke ezì na-ama abụba nwere ike ịbawanye nri ezì nke ukwuu, na-abawanye uru dị arọ, ma ghara ibelata itinye protein nri.

2. Mmetụta nke GABA na mgbaze eriri afọ na usoro Endocrine Dị ka onye na-ahụ maka neurotransmitter ma ọ bụ modulator, GABA na-arụ ọrụ dị ukwuu na mpaghara autonomic ụjọ usoro nke vertebrates.

3. Mmetụta nke GABA na motility eriri afọ.GABA dị n'ọtụtụ ebe na tract gastrointestinal, na GABA immunoreactive nerve fibers ma ọ bụ sel akwara dị mma dị na usoro ụjọ ahụ na akpụkpọ anụ nke tract gastrointestinal mammalian, GABA endocrin cell na-ekesakwa na epithelium nke mucosa Gastric.GABA nwere mmetụta nchịkwa na sel eriri afọ dị nro, sel endocrine na sel ndị na-abụghị endocrine.Exogenous GABA nwere mmetụta inhibitory dị ịrịba ama na akụkụ eriri afọ dịpụrụ adịpụ nke oke, nke na-egosipụta na ntụrụndụ na mbelata njupụta njupụta nke akụkụ eriri afọ dịpụrụ adịpụ.Usoro mgbochi a nke GABA nwere ike ịbụ site na igbochi cholinergic na / ma ọ bụ usoro cholinergic nke eriri afọ, Na-eme ihe na-enweghị usoro adrenergic;Ọ nwekwara ike ijikọ onwe ya na onye na-anabata GABA kwekọrọ na sel akwara eriri afọ.

4. GABA na-achịkwa metabolism anụmanụ.GABA nwere ike inwe mmetụta dịgasị iche iche na usoro eriri afọ dị ka hormone mpaghara, dị ka ụfọdụ glands na hormones endocrine.N'okpuru ọnọdụ vitro, GABA nwere ike kpalie nzuzo nke hormone uto site na ịgbalite onye na-anabata GABA na afọ.Hormone na-eto eto anụmanụ nwere ike ịkwalite njikọ nke ụfọdụ peptides na imeju (dị ka IGF-1), mee ka ọnụ ọgụgụ metabolic nke mkpụrụ ndụ anụ ahụ dịkwuo elu, na-abawanye ụba ma na-eri nri ngbanwe nke anụmanụ, N'otu oge ahụ, ọ gbanwere nkesa. nke nri nri na anụ ahụ;Enwere ike ịkọ nkọ na mmetụta na-akwalite uto nke GABA nwere ike jikọta ya na nhazi ya nke ọrụ hormone nke uto site na imetụta ọrụ nke usoro endocrine ụjọ.