Izina:γ- aside aminobutyric（GABA）

URUBANZA No.:56-12-2

Synonyme: 4-Aacide minobutyric;Ammonia butyric aside;Acide ya pipecolike.

1. Ingaruka za GABA mukugaburira amatungo zigomba guhora mugihe runaka.Ifunguro ryibiryo rifitanye isano rya hafi n’imikorere y’amatungo n’inkoko.Nkigikorwa cyimyitwarire igoye, kugaburira bigenzurwa cyane na sisitemu yo hagati.Centre yo guhaga (Ventromedial nucleus ya hypothalamus) hamwe na centre yo kugaburira (agace ka hypothalamus kuruhande) ni kugenzura inyamaswa.

Ikigo cyibanze cyimirire GABA irashobora gutera kugaburira amatungo muguhagarika ibikorwa byikigo gihaza, byongera ubushobozi bwo kugaburira amatungo.Ubushakashatsi bwinshi bwerekanye ko gutera urugero runaka rwa GABA mu bice bitandukanye byubwonko bwinyamaswa bishobora guteza imbere kugaburira amatungo kandi bigira ingaruka ziterwa na dose.Ongeraho GABA mumirire yibanze yingurube zibyibushye zirashobora kongera cyane ibiryo byingurube, kongera ibiro, kandi ntibigabanye gukoresha protein ibiryo.

2. Ingaruka za GABA ku igogora rya gastrointestinal na sisitemu ya Endocrine Nka neurotransmitter cyangwa modulator, GABA igira uruhare runini muri sisitemu ya Autonomic nervous system ya vertebrates.

3. Ingaruka ya GABA kumitsi ya gastrointestinal.GABA igaragara cyane mu nzira ya gastrointestinal, na GABA fibre immunoreactive nerv fibre cyangwa selile selile nervice igaragara muri sisitemu ya nervice na membrane ya mammalian gastrointestinal tract, selile endocrine selile na GAB ikwirakwizwa muri epitelium ya mucosa Gastric.GABA igira ingaruka zingirakamaro kumitsi ya gastrointestinal yoroshye yimitsi, selile endocrine selile na selile endocrine.Exogenous GABA igira ingaruka zikomeye zo guhagarika ibice byo mu mara byitaruye byimbeba, bigaragarira mu kuruhuka no kugabanya amplitude igabanya ibice byo mu mara byitaruye.Ubu buryo bwo kubuza GABA bushobora kuba binyuze mukubuza cholinergique na / cyangwa sisitemu ya cholinergique yo mu mara, Gukora nta sisitemu ya adrenergique;Irashobora kandi kwigenga guhuza reseptor ya GABA ihuye ningirabuzimafatizo zo munda zoroheje.

4. GABA igenga metabolism yinyamaswa.GABA irashobora kugira ingaruka zitandukanye muri sisitemu ya gastrointestinal nka hormone yaho, nko kuri glande zimwe na zimwe na hormone endocrine.Mugihe cya vitro, GABA irashobora gutera imbaraga zo gusohora imisemburo ikura mugukoresha reseptor ya GABA mugifu.Imisemburo ikura yinyamaswa irashobora guteza imbere synthesis ya peptide zimwe na zimwe mu mwijima (nka IGF-1), kongera umuvuduko wa metabolike yingirabuzimafatizo, kongera umuvuduko wo gukura no kugaburira ibiryo by’inyamaswa, Muri icyo gihe, byanahinduye ikwirakwizwa by'intungamubiri zigaburira mu mubiri w'inyamaswa;Turashobora kuvuga ko gukura kwiterambere rya GABA bishobora kuba bifitanye isano no kugenzura imikorere yimisemburo ikura bigira ingaruka kumikorere ya sisitemu ya Endocrine nervice.