Lebitso :γ- aminobutyric acid（GABA）

CAS No.: 56-12-2

Litlhaloso tse tšoanang: 4-Aminobutyric acid;Ammonia butyric acid;Pipecolic acid.

1. Tšusumetso ea GABA ho fepa liphoofolo e hloka ho lula e le teng ka nako e itseng.Ho ja lijo ho amana haufi-ufi le ts'ebetso ea tlhahiso ea mehlape le likhoho.E le mosebetsi o rarahaneng oa boitšoaro, ho fepa ho laoloa haholo-holo ke tsamaiso ea methapo e bohareng.Setsi sa satiety (Ventromedial nucleus of the hypothalamus) le setsi sa phepo (lateral hypothalamus area) ke ba laolang liphoofolo.

Setsi sa motheo sa lijo GABA se ka etsa hore ho jeoe liphoofolo ka ho thibela mosebetsi oa setsi sa satiety, ho matlafatsa bokhoni ba ho fepa liphoofolo.Liphuputso tse ngata li bontšitse hore ho kenya tekanyo e itseng ea GABA libakeng tse fapaneng tsa boko ba liphoofolo ho ka khothalletsa phepelo ea liphoofolo haholo 'me ha ba le phello e itšetlehileng ka tekanyo ea litekanyetso.Ho eketsa GABA ho lijo tsa motheo tsa likolobe tse nontšang ho ka eketsa haholo lijo tsa likolobe, ho eketsa boima ba 'mele,' me ho se ke ha fokotsa tšebeliso ea liprotheine tsa phepo.

2. Phello ea GABA ho tšilo ea mala le tsamaiso ea Endocrine Joaloka neurotransmitter kapa modulator, GABA e phetha karolo e pharaletseng tsamaisong ea methapo ea peripheral Autonomic ea li-vertebrates.

3. Phello ea GABA ka gastrointestinal motility.GABA e teng ka bongata ka har'a pampitšana ea mala, 'me GABA immunoreactive nerve fibers kapa lisele tse ntle tsa methapo li teng tsamaisong ea methapo le lera la mammalian gastrointestinal tract, lisele tsa GABA tsa endocrine li boetse li ajoa ka epithelium ea Gastric mucosa.GABA e na le phello ea taolo ho lisele tsa mesifa ea ka mpeng, lisele tsa endocrine le lisele tse seng tsa endocrine.Exogenous GABA e na le phello e kholo ea inhibitory likarolong tse ka thōko tsa mala a likhoto, tse bonahalang ka ho phomola le ho fokotseha ha amplitude ea likarolo tse ka thōko tsa mala.Mokhoa ona oa ho thibela GABA ho ka etsahala hore e be ka ho thibela tsamaiso ea cholinergic le / kapa e seng ea cholinergic ea mala, Ho sebetsa ntle le tsamaiso ea adrenergic;E ka boela ea itlama ka boikemelo ho mokelikeli oa GABA o lumellanang le lisele tsa mesifa ea mala a boreleli.

4. GABA e laola metabolism ea liphoofolo.GABA e ka ba le litlamorao tse ngata tsamaisong ea mala joalo ka lihormone tsa lehae, joalo ka litšoelesa tse itseng le lihomone tsa endocrine.Tlas'a maemo a in vitro, GABA e ka susumetsa secretion ea kholo ea hormone ka ho kenya tšebetsong mokelikeli oa GABA ka mpeng.Hormone ea kholo ea liphoofolo e ka khothaletsa tlhahiso ea li-peptide tse ling sebeteng (joalo ka IGF-1), e eketsa sekhahla sa metabolism ea lisele tsa mesifa, e eketsa sekhahla sa kholo le sekhahla sa phepelo ea phepelo ea liphoofolo, ka nako e ts'oanang, e boetse e fetotse kabo. ea limatlafatsi tsa phepo 'meleng oa phoofolo;Ho ka nahanoa hore phello e khothalletsang kholo ea GABA e ka 'na ea amana le taolo ea eona ea ts'ebetso ea hormone ea ho hōla ka ho ama mosebetsi oa tsamaiso ea methapo ea Endocrine.