Igama :γ- i-aminobutyric acid(GABA）

Inombolo yeCAS: 56-12-2

Izithethantonye: 4-Ai-minobutyric acid;Ammonia butyric acid;Pipecolic acid.

1. Impembelelo yeGABA ekutyisweni kwezilwanyana kufuneka ihlale ingaguquguquki kwixesha elithile.Ukutya okutyiwayo kunxulumene kakhulu nokusebenza kwemveliso yemfuyo kunye neenkukhu.Njengomsebenzi wokuziphatha onzima, ukondla kulawulwa ikakhulu yinkqubo ye-nervous central.Iziko lokuhlutha (i-Ventromedial nucleus ye-hypothalamus) kunye neziko lokutya (indawo ye-hypothalamus esecaleni) ngabalawuli bezilwanyana.

Iziko elisisiseko lokutya i-GABA inokubangela ukutya kwezilwanyana ngokuthintela umsebenzi weziko lokuhlutha, ukuphucula amandla okutya kwezilwanyana.Uphononongo oluninzi lubonise ukuba ukutofa uluhlu lwedosi ethile ye-GABA kwimimandla eyahlukeneyo yobuchopho bezilwanyana kunokukhuthaza ngokubonakalayo ukondla kwezilwanyana kwaye kube nesiphumo esixhomekeke kwithamo.Ukongeza i-GABA ekutyeni okusisiseko kweehagu ezityetyisiweyo kunokunyusa kakhulu ukutya kweehagu, ukonyusa ubunzima, kwaye kunganciphisi ukusetyenziswa kweprotheyini yokutya.

2. Umphumo we-GABA kwi-gastrointestinal digestion kunye nenkqubo ye-Endocrine Njenge-neurotransmitter okanye i-modulator, i-GABA idlala indima ebanzi kwi-peripheral Autonomic nervous system of vertebrates.

3. Impembelelo ye-GABA kwi-motility yesisu.I-GABA ikhona ngokubanzi kwi-gastrointestinal tract, kwaye i-GABA i-immunoreactive nerve fibers okanye iiseli ze-nerve ezintle zikhona kwi-nervous system kunye ne-membrane ye-mammalian gastrointestinal tract, iiseli ze-GABA ze-endocrine nazo zisasazwa kwi-epithelium ye-Gastric mucosa.I-GABA inefuthe lokulawula kwiiseli ze-muscle ezigudileyo zesisu, iiseli ze-endocrine kunye neeseli ezingezona ze-endocrine.I-GABA ye-Exogenous inempembelelo ebalulekileyo yokuthintela kumacandelo e-intestinal angasese eegundane, ezibonakaliswa ekuphumleni kunye nokunciphisa i-contraction amplitude yamacandelo angasese amathumbu.Le ndlela yokuthintela ye-GABA kunokwenzeka ukuba ibe ngokuthintela inkqubo ye-cholinergic kunye / okanye engeyiyo ye-cholinergic yamathumbu, Ukusebenza ngaphandle kwenkqubo ye-adrenergic;Inokuthi ibophe ngokuzimeleyo kwi-receptor ye-GABA ehambelanayo kwiiseli ze-intestinal smooth muscle.

4. I-GABA ilawula i-metabolism yezilwanyana.I-GABA ingaba neempembelelo ezininzi kwiinkqubo zesisu njenge-hormone yendawo, njengamadlala athile kunye namahomoni e-endocrine.Ngaphantsi kweemeko ze-in vitro, i-GABA inokuvuselela ukukhuselwa kwehomoni yokukhula ngokuvula i-GABA receptor esiswini.Ihomoni yokukhula kwezilwanyana inokukhuthaza ukuhlanganiswa kwezinye iipeptides esibindini (ezifana ne-IGF-1), yandise isantya semetabolism yeeseli zemisipha, yandise izinga lokukhula kunye nesantya sokuguqula ukutya kwezilwanyana, Kwangaxeshanye, iphinde yatshintsha ukuhanjiswa. isondlo sezondlo kumzimba wesilwanyana;Inokucingelwa ukuba impembelelo yokukhuthaza ukukhula kwe-GABA inokuhambelana nokulawulwa kwayo komsebenzi we-hormone yokukhula ngokuchaphazela umsebenzi we-nervous Endocrine system.