Zita :γ- aminobutyric asidhi(GABA）

Nhamba yeCAS:56-12-2

Mashoko anoreva zvakafanana: 4-Aminobutyric acid;Ammonia butyric acid;Pipecolic acid.

1. Kufuridzirwa kweGABA pakudya kwemhuka kunoda kuva nguva dzose mune imwe nguva yenguva.Kudya kwekudya kunodyidzana zvakanyanya nekugadzirwa kwezvipfuyo nehuku.Sekuita kwakaoma kwekuita maitiro, kudyisa kunonyanya kudzorwa neiyo central nervous system.Iyo satiety centre (Ventromedial nucleus ye hypothalamus) uye nzvimbo yekudyisa (lateral hypothalamus area) inodzora mhuka.

Iyo yakakosha nzvimbo yekudya GABA inogona kukurudzira kudya kwemhuka nekudzivisa basa re satiety centre, kuwedzera kugona kwekudya kwemhuka.Zvidzidzo zvakawanda zvakaratidza kuti kubaya imwe dhamo reGABA munzvimbo dzakasiyana dzehuropi dzemhuka kunogona kukurudzira zvakanyanya kudya kwemhuka uye kuve nemhedzisiro inoenderana nedoro.Kuwedzera GABA kune kudya kwekutanga kwenguruve dzakakora kunogona kuwedzera zvakanyanya kudya kwenguruve, kuwedzera uremu, uye usaderedze mapuroteni ekudya.

2. Mhedzisiro yeGABA pane gastrointestinal digestion uye Endocrine system Seyeurotransmitter kana modulator, GABA inobata basa rakawanda munharaunda yeAutonomic nervous system ye vertebrates.

3. Mhedzisiro yeGABA pane gastrointestinal motility.GABA inowanikwa zvakanyanya mumakumbo emimba, uye GABA immunoreactive nerve fibers kana masero emagetsi ehutano aripo muhutano hwemagetsi uye membrane yemammalian gastrointestinal tract, GABA endocrine masero anogoverwawo mu epithelium yeGastric mucosa.GABA ine regulatory mhedzisiro pagastrointestinal yakatsetseka tsandanyama masero, endocrine masero uye asiri endocrine masero.Exogenous GABA ine zvakakosha inhibitory effect pazvikamu zvemukati zvemukati zvemakonzo, izvo zvinoratidzwa mukuzorora uye kupikisa amplitude kuderedzwa kwezvikamu zvemukati zvega.Iyi inhibitory mechanism yeGABA inogona kunge iri kuburikidza nekudzivisa cholinergic uye / kana kwete cholinergic systems yehuku, Kuita pasina adrenergic system;Iyo inogona zvakare kuzvisungirira yakazvimirira kune inoenderana GABA receptor pane intestinal inotsvedza tsandanyama maseru.

4. GABA inodzora mhuka metabolism.GABA inogona kuva neyakasiyana-siyana yemhedzisiro mugastrointestinal system sehomoni yemuno, senge pane mamwe magland uye endocrine mahormone.Pasi pemamiriro ezvinhu emu vitro, GABA inogona kukurudzira kuvanzika kwekukura kwehomoni nekuita iyo GABA receptor mudumbu.Mhuka yekukura kwehomoni inogona kukurudzira kuumbwa kwemamwe mapeptide muchiropa (senge IGF-1), kuwedzera metabolic rate yemasero emhasuru, kuwedzera kukura kwekukura uye kushandurwa kwekudya kwemhuka, Panguva imwecheteyo, yakashandurawo kugoverwa. chekudya chinovaka muviri mumuviri wemhuka;Zvinogona kufungidzirwa kuti kukura kwekusimudzira kweGABA kunogona kunge kwakabatana nekugadzirisa kwayo kwekukura kwehomoni basa nekukanganisa basa rehutano hweEndocrine system.