Dzina :γ- aminobutyric acid(GABA）

CAS No.: 56-12-2

Mawu ofanana ndi mawu: 4-Aminobutyric acid;Ammonia butyric acid;Pipecolic acid.

1. Chikoka cha GABA pa kudyetsa ziweto chiyenera kukhala chosasintha pakapita nthawi.Kudya kwa chakudya kumagwirizana kwambiri ndi momwe ziweto zimagwirira ntchito komanso nkhuku.Monga zovuta zamakhalidwe, kudyetsa kumayendetsedwa makamaka ndi dongosolo lapakati lamanjenje.Malo okhuta (Ventromedial nucleus of the hypothalamus) ndi malo odyetserako chakudya (lateral hypothalamus area) ndi owongolera nyama.

Malo oyambira azakudya a GABA amatha kuyambitsa kudyetsedwa kwa ziweto poletsa ntchito ya malo okhuta, kukulitsa luso lodyetsa nyama.Kafukufuku wambiri wasonyeza kuti kubaya mlingo wina wa GABA m'madera osiyanasiyana a ubongo wa nyama kungathandize kwambiri kudyetsa nyama komanso kukhala ndi zotsatira zodalira mlingo.Kuonjezera GABA ku zakudya zoyambirira za nkhumba zonenepa zimatha kuonjezera kwambiri kudya kwa nkhumba, kuonjezera kulemera, komanso kuchepetsa kugwiritsa ntchito mapuloteni a chakudya.

2. Zotsatira za GABA pa chimbudzi cha m'mimba ndi dongosolo la Endocrine Monga neurotransmitter kapena modulator, GABA imagwira ntchito yaikulu mu zotumphukira za Autonomic nervous system of vertebrates.

3. Zotsatira za GABA pakuyenda kwa m'mimba.GABA imapezeka kwambiri m'matumbo a m'mimba, ndipo GABA immunoreactive nerve fibers kapena maselo abwino a mitsempha alipo mu mitsempha ya m'mimba ndi m'mimba ya m'mimba, maselo a GABA endocrine amagawidwanso mu epithelium ya Gastric mucosa.GABA imakhala ndi mphamvu yoyendetsera m'mimba yosalala ya minofu, ma cell a endocrine ndi ma cell omwe si a endocrine.Exogenous GABA ali kwambiri chopinga kwambiri pa akutali matumbo zigawo makoswe, amene akuwonetseredwa mu ulesi ndi contraction matalikidwe kuchepetsa akutali matumbo zigawo.Njira yoletsa iyi ya GABA ikhoza kukhala kudzera mu kuletsa kwa cholinergic ndi/kapena kachitidwe kopanda cholinergic m'matumbo, Kuchita popanda dongosolo la adrenergic;Ikhozanso kumangiriza paokha ku GABA cholandirira pamatumbo osalala a minofu.

4. GABA imayendetsa kagayidwe ka nyama.GABA ikhoza kukhala ndi zotsatira zosiyanasiyana m'matumbo a m'mimba monga mahomoni am'deralo, monga pa glands zina ndi mahomoni a endocrine.Pansi pazikhalidwe za in vitro, GABA imatha kulimbikitsa kutulutsa kwa timadzi tating'onoting'ono poyambitsa cholandilira cha GABA m'mimba.Hormone yakukula kwa nyama imatha kulimbikitsa kuphatikizika kwa ma peptide ena m'chiwindi (monga IGF-1), kukulitsa kuchuluka kwa kagayidwe kachakudya ka maselo a minofu, kukulitsa kuchuluka kwa kukula ndi kutembenuka kwa chakudya cha nyama, Nthawi yomweyo, idasinthanso kugawa. kusowa kwa zakudya m'thupi la nyama;Zitha kuganiziridwa kuti kulimbikitsa kukula kwa GABA kungakhale kogwirizana ndi kayendetsedwe kake ka ntchito ya kukula kwa hormone pokhudza ntchito ya mitsempha ya Endocrine.