Sekungamashumi eminyaka i-butyric acid isetshenziswa embonini yokudla ukuze kuthuthukiswe impilo yamathumbu nokusebenza kwezilwane.Izizukulwane eziningi ezintsha zethulwe ukuthuthukisa ukuphathwa komkhiqizo kanye nokusebenza kwawo kusukela ukuhlolwa kokuqala kwenziwa ngawo-80s.

Sekungamashumi eminyaka i-butyric acid isetshenziswa embonini yokudla ukuze kuthuthukiswe impilo yamathumbu nokusebenza kwezilwane.Izizukulwane eziningi ezintsha zethulwe ukuthuthukisa ukuphathwa komkhiqizo nokusebenza kwawo kusukela ukuhlolwa kokuqala kwenziwa ngawo-80s..

1. Ukuthuthukiswa kwe-asidi ye-butyric njengesengezo sokudla

1980s > I-Butyric Acid yayisetshenziselwa ukuthuthukisa ukuthuthukiswa kwe-rumen

1990s> usawoti we-butyrin acid osetshenziselwa ukuthuthukiswa kokusebenza kwezilwane

2000s> usawoti oboshwe athuthukile: ukutholakala okungcono kwamathumbu kanye nephunga elincane

2010s> I-asidi entsha e-esterified nesebenza kahle kakhudlwana i-butyric

Namuhla imakethe ibuswa i-butyric acid evikelwe kahle.Abakhiqizi bokuphakelayo abasebenza nalezi zithako abanazo izinkinga ngezinkinga zephunga futhi umphumela wezithasiselo empilweni yamathumbu nokusebenza ungcono.Inkinga ngemikhiqizo evamile eboshwe nokho ukugcwala okuphansi kwe-butyric acid.Usawoti oboshwe ngokuvamile uqukethe i-25-30% ye-butyric acid, ephansi kakhulu.

Ukuthuthukiswa kwakamuva kwezithasiselo ezisekelwe ku-butyric acid okuphakelayo ukuthuthukiswa kwe-ProPhorce™ SR: i-glycerol esters ye-butyric acid.Lawa ma-triglycerides e-butyric acid ngokwemvelo angatholakala obisini noju.Ziwumthombo osebenza kahle kakhulu we-butyric acid evikelwe ene-butyric acid efika ku-85%.I-Glycerol inendawo yokuba nama-molecule amathathu e-butyric acid axhunywe kuyo ngalokho okubizwa ngokuthi 'amabhondi e-ester'.Lokhu kuxhumana okunamandla kukhona kuwo wonke ama-triglycerides futhi kungaphulwa kuphela ngama-enzyme athile (lipase).Esitshalweni nasesiswini i-tributyrin ihlala iqinile futhi emathunjini lapho i-pancreatic lipase itholakala kalula i-butyric acid ikhishwa.

Indlela yokwenza i-esterifying butyric acid ibonakale iyindlela ephumelela kakhulu yokudala i-butyric acid engenaphunga ekhishwa lapho uyifuna khona: emathunjini.

Umsebenzi we-Tributyrin

1.Ilungisa i-villi yamathumbu amancane ezilwane futhi ivimbele amagciwane ayingozi amathumbu.

2.Ithuthukisa ukumuncwa kanye nokusetshenziswa kwezakhamzimba.

3.Inganciphisa isifo sohudo kanye nokucindezeleka kokulunyulwa kwezilwane ezisencane.

4.Ikhuphula izinga lokusinda kanye nenzuzo yansuku zonke yesisindo sezilwane ezisencane.