IbisobanuroUbushakashatsi bwakozwe hagamijwe kwiga ku ngaruka za diludine ku mikorere y’amagi no ku bwiza bw’amagi no kwegera uburyo bw’ingaruka hagaragazwa ibipimo ngenderwaho by’amagi na serumu 1024 Inkoko za ROM zagabanyijwemo amatsinda ane buri imwe muri yo ikaba irimo kopi enye za 64 inkoko imwe, Amatsinda yo kuvura yakiriye indyo yibanze yongeweho 0, 100, 150, 200 mg / kg diludine kuri 80 d.Ibisubizo byari ibi bikurikira.Kwiyongera kwa diludine mumirire byateje imbere inkoko zo gutera, murizo 150 mg / kg kuvura byari byiza;igipimo cyacyo cy’abalayiki cyiyongereyeho 11.8% (p <0.01), ihinduka ry’amagi ryaragabanutseho 10.36% (p <0 01).Ibiro by'amagi byariyongereye hamwe no kwiyongera kwa diludine.Diludine yagabanije cyane serum ya acide ya uric (p <0.01);kongeramo diludine byagabanije cyane serumu Ca.²⁺n'ibirimo fosifike idasanzwe, hamwe no kongera ibikorwa bya alkine fosifata (ALP) ya serumu (p <0.05), bityo byagize ingaruka zikomeye mukugabanya kumena amagi (p <0.05) nibidasanzwe (p <0.05);diludine yongereye cyane uburebure bwa albumen.Agaciro keza (p <0.01), ubunini bwibishishwa hamwe nuburemere bwibishishwa (p <0.05), 150 na 200mg / kg diludine nabyo byagabanije choleasterol yose mumuhondo w amagi (p <0 05), ariko byongera uburemere bwumuhondo w amagi (p <0.05).Byongeye kandi, diludine ishobora kongera ibikorwa bya lipase (p <0.01), ikanagabanya ibirimo triglyceride (TG3) (p <0.01) na cholesterol (CHL) (p <0 01) muri serumu, byagabanije ijanisha ryibinure byo munda (p <0.01) n'ibinure by'umwijima (p <0.01), byari bifite ubushobozi bwo gukumira inkoko umwijima.Diludine yongereye cyane ibikorwa bya SOD muri serumu (p <0 01) mugihe yongewe kumirire irenga 30d.Howeve, nta tandukaniro rikomeye ryabonetse mubikorwa bya GPT na GOT ya serumu hagati yo kugenzura no kuvura itsinda.Hemejwe ko diludine ishobora kubuza ururenda rwa selile okiside

Amagambo y'ingenziDiludine;inkoko;SOD;cholesterol;triglyceride, lipase

 

Diludine nigitabo kidafite intungamubiri zirwanya vitamine anti-okiside kandi gifite ingaruka^[1-3]yo kubuza okiside ya biologiya no guhagarika ingirangingo z'uturemangingo, n'ibindi. Mu myaka ya za 70, impuguke mu by'ubuhinzi ya Lativiya mu cyahoze ari Leta Zunze Ubumwe z'Abasoviyeti yasanze diludine yagize ingaruka^[4]yo guteza imbere imikurire y’inkoko no kurwanya ubukonje no gusaza ku bimera bimwe na bimwe.Byagaragaye ko diludine idashobora guteza imbere imikurire y’inyamaswa gusa, ahubwo inateza imbere imikorere y’imyororokere y’inyamaswa ku buryo bugaragara kandi ikazamura umuvuduko w’inda, umusaruro w’amata, umusaruro w’amagi ndetse n’igipimo cy’inyamaswa z’umugore^{[1, 2, 5-7]}.Ubushakashatsi bwa diludine mu Bushinwa bwatangiye guhera mu myaka ya za 1980, kandi ubushakashatsi bwinshi bwerekeranye na diludine mu Bushinwa bugarukira gusa ku gukoresha kugeza ubu, kandi haravuzwe ibigeragezo bike ku bijyanye n’inyoni.Chen Jufang (1993) yatangaje ko diludine ishobora kuzamura umusaruro w'amagi n'uburemere bw'amagi y'inkoko, ariko ntibyimbitse.^[5]kwiga uburyo bwibikorwa byabwo.Kubwibyo, twashyize mubikorwa ubushakashatsi bufatika bwingaruka nuburyo bukoreshwa mu kugaburira inkoko ziteye hamwe nimirire yuzuye hamwe na diludine, kandi igice kimwe cyibisubizo ubu kivugwa kuburyo bukurikira:

Imbonerahamwe 1 Ibigize nintungamubiri zimirire yubushakashatsi

%

------------------------------------------------ --------------------------------------------

Ibigize indyo yintungamubiri

------------------------------------------------ --------------------------------------------

Ibigori 62 ME③ 11.97

Ibishyimbo 20 CP 17.8

Ifunguro ry'amafi 3 Ca 3.42

Ifunguro ryihuse 5 P 0.75

Ifunguro ryamagufa 2 M et 0.43

Ifunguro ryamabuye 7.5 M et Cys 0,75

Methionine 0.1

Umunyu 0.3

Multivitamine① 10

Kurikirana ibintu② 0.1

------------------------------------------------ ----------------------------------------

① Multivitamine: 11mg ya riboflavin, 26mg ya aside folike, 44mg ya oryzanin, 66mg ya niacin, 0.22mg ya biotine, 66mg ya B6, 17.6ug ya B12, 880mg ya choline, 30mg ya VK, 66IU ya V_E, 6600ICU ya V._Dna 20000ICU ya V._A, byongewe kuri buri kilo cyimirire;na 10g multivitamine yongewe kuri buri 50kg yimirire.

Elements Kurikirana ibintu (mg / kg): 60 mg ya Mn, 60mg ya Zn, 80mg ya Fe, 10mg ya Cu, 0.35mg ya I na 0.3mg ya Se byongewe kuri buri kilo cyimirire.

Unit Igice cyingufu za metabolizable bivuga MJ / kg.

 

1. Ibikoresho nuburyo

1.1 Ibikoresho by'ibizamini

Beijing Sunpu Biochem.& Ikoranabuhanga.Co, Ltd. igomba gutanga diludine;kandi inyamaswa yipimishije igomba kwerekeza ku nkoko z’ubucuruzi z’Abaroma zimaze iminsi 300.

 

Indyo yubushakashatsi: indyo yikigereranyo igomba gutegurwa ukurikije uko ibintu bimeze mugihe cyo kubyara hashingiwe ku gipimo cya NRC, nkuko bigaragara mu mbonerahamwe ya 1.

1.2 Uburyo bwo kugerageza

1.2.1 Ikigeragezo cyo kugaburira: igeragezwa ryo kugaburira rigomba gushyirwa mubikorwa mumurima wa Company ya Hongji mumujyi wa Jiande;1024 Inkoko zitera Abaroma zigomba gutoranywa zigabanywamo amatsinda ane uko bishakiye kandi buri gice kubice 256 (buri tsinda rigomba gusubirwamo inshuro enye, kandi buri nkoko igomba gusubirwamo inshuro 64);inkoko zigomba kugaburirwa ibiryo bine birimo ibintu bitandukanye bya diludine, kandi 0, 100, 150, 200mg / kg y'ibiryo bigomba kongerwaho buri tsinda.Ikizamini cyatangiye ku ya 10 Mata 1997;n'inkoko zashoboraga kubona ibiryo no gufata amazi kubuntu.Ibiryo byafashwe na buri tsinda, igipimo cyo gutera, umusaruro w'igi, amagi yamenetse n'umubare w'amagi adasanzwe bigomba kwandikwa.Byongeye kandi, ikizamini cyarangiye ku ya 30 Kamena 1997.

1.2 ubunini bw'igikonoshwa, igipimo cy'umuhondo, uburemere bugereranije bw'umuhondo, n'ibindi. Byongeye kandi, ibirimo cholesterol mu muhondo bigomba gupimwa hakoreshejwe uburyo bwa COD-PAP imbere ya Cicheng reagent yakozwe na Ningbo Cixi Biochemical Test Plant.

1.2.3 Gupima indangagaciro ya biohimiki ya serumu: inkoko 16 zipimwa zigomba gufatwa muri buri tsinda igihe cyose ikizamini cyashyizwe mu bikorwa iminsi 30 nigihe ikizamini kirangiye cyo gutegura serumu nyuma yo gutoranya amaraso ava mumitsi iva ibaba.Serumu igomba kubikwa ku bushyuhe buke (-20 ℃) ​​kugirango bapime ibipimo ngengabuzima bijyanye.Ijanisha ryibinure byo munda nibirimo lipide yumwijima bigomba gupimwa nyuma yo kubaga no gukuramo ibinure byo munda numwijima nyuma yo guterwa amaraso.

Superoxide disutase (SOD) igomba gupimwa hakoreshejwe uburyo bwo kwiyuzuzamo imbere ya kit reagent yakozwe na Biochem ya Beijing Huaqing.& Ikoranabuhanga.Ikigo cy'ubushakashatsi.Acide ya uric (UN) muri serumu igomba gupimwa hakoreshejwe uburyo U ricase-PAP imbere ya Cicheng reagent kit;triglyceride (TG3) igomba gupimwa ukoresheje GPO-PAP uburyo bumwe bwintambwe imbere ya Cicheng reagent kit;lipase igomba gupimwa ukoresheje nephelometrie imbere ya Cicheng reagent kit;serumu yuzuye cholesterol (CHL) igomba gupimwa ukoresheje uburyo bwa COD-PAP imbere ya Cicheng reagent kit;glutamic-pyruvic transaminase (GPT) igomba gupimwa ukoresheje colorimetry imbere ya Cicheng reagent kit;glutamic-oxalacetic transaminase (GOT) igomba gupimwa ukoresheje colorimetry imbere ya Cicheng reagent kit;fosifata ya alkaline (ALP) igomba gupimwa ukoresheje uburyo bwikigereranyo imbere ya Cicheng reagent kit;calcium ya calcium (Ca.²⁺) muri serumu igomba gupimwa ukoresheje methylthymol ubururu bwa complexe yubururu imbere ya Cicheng reagent kit;fosifore idasanzwe (P) igomba gupimwa hakoreshejwe uburyo bwubururu bwa molybdate imbere ya Cicheng reagent kit.

 

2 Ikizamini

2.1 Ingaruka zo gushyiraho imikorere

Ibikorwa byo gushyira amatsinda atandukanye yatunganijwe ukoresheje diludine bigaragara mu mbonerahamwe ya 2.

Imbonerahamwe 2 Imikorere yinkoko zigaburirwa nimirire yibanze yongerewe ninzego enye za diludine

 

Umubare wa diludine ugomba kongerwamo (mg / kg)
	0	100	150	200
Kugaburira ibiryo (g)
Igipimo cyo gushyira (%)
Ikigereranyo cy'uburemere bw'igi (g)
Ikigereranyo cyibikoresho n'amagi
Igipimo cy'amagi yamenetse (%)
Igipimo cy'amagi adasanzwe (%)

 

Kuva ku mbonerahamwe ya 2, igipimo cyo gushyiraho amatsinda yose yatunganijwe hakoreshejwe diludine cyatejwe imbere bigaragara, aho ingaruka iyo itunganijwe ukoresheje 150mg / kg ari nziza (kugeza kuri 83.36%), naho 11.03% (p <0.01) iratera imbere ugereranije hamwe nitsinda ryerekana;niyo mpamvu diludine ifite ingaruka zo kuzamura igipimo cyo gushyira.Urebye uburemere buringaniye bwamagi, uburemere bwamagi buriyongera (p> 0.05) hamwe no kongera diludine mumirire ya buri munsi.Ugereranije nitsinda ryerekanwe, itandukaniro mubice byose byatunganijwe mumatsinda yatunganijwe ukoresheje 200mg / kg ya diludine ntabwo bigaragara mugihe 1.79g yo kugaburira ibiryo byongeweho ugereranije;icyakora, itandukaniro rigenda rigaragara buhoro buhoro hamwe no kwiyongera kwa diludine, kandi itandukaniro ryikigereranyo cyibintu n'amagi mubice byatunganijwe biragaragara (p <0.05), kandi ingaruka nibyiza iyo 150mg / kg ya diludine kandi ni 1.25: 1 igabanutse kuri 10.36% (p <0.01) ugereranije nitsinda ryerekanwe.Urebye uhereye kumagi yamenetse yibice byose byatunganijwe, igipimo cyamagi yamenetse (p <0.05) kirashobora kugabanuka mugihe diludine yongewe mumirire ya buri munsi;kandi ijanisha ryamagi adasanzwe aragabanuka (p <0.05) hamwe no kongera diludine.

 

2.2 Ingaruka kumiterere yamagi

Urebye ku mbonerahamwe ya 3, igipimo cyerekana imiterere yamagi hamwe nuburemere bwihariye bwamagi ntabwo bigira ingaruka (p> 0.05) mugihe diludine yongewe kumirire ya buri munsi, kandi uburemere bwigikonoshwa bwiyongera hamwe no kongera diludine yongewe kumirire ya buri munsi, aho uburemere bwibishishwa bwiyongera kuri 10.58% na 10,85% (p <0.05) ugereranije nitsinda ryerekanwe iyo hiyongereyeho 150 na 200mg / kg ya diludine;umubyimba w'igikonoshwa cy'amagi wiyongera hamwe no kongera diludine mu ndyo ya buri munsi, aho umubyimba w'igikonjo cy'igi wiyongera kuri 13.89% (p <0.05) iyo hiyongereyeho 100mg / kg ya diludine ugereranije n'amatsinda yerekanwe, n'ubunini y'ibishishwa by'amagi byiyongera kuri 19.44% (p <0.01) na 27.7% (p <0.01) mugihe hiyongereyeho 150 na 200mg / kg.Igice cya Haugh (p <0.01) cyatejwe imbere bigaragara iyo diludine yongeyeho, byerekana ko diludine igira ingaruka zo guteza imbere synthesis ya alubumu yuzuye yamagi yera.Diludine ifite umurimo wo kunoza indangagaciro yumuhondo, ariko itandukaniro ntabwo rigaragara (p <0.05).Ibiri muri cholesterol yumuhondo wamagi yitsinda ryose biratandukanye kandi birashobora kugabanuka (p <0.05) nyuma yo kongeramo 150 na 200mg / kg ya diludine.Uburemere bugereranije bw'umuhondo w'igi buratandukanye hagati yawo bitewe n'ubwinshi bwa diludine yongeweho, aho uburemere bugereranije bw'umuhondo w'igi butunganijwe neza kuri 18.01% na 14.92% (p <0.05) mugihe 150mg / kg na 200mg / kg ugereranije hamwe nitsinda ryerekanwe;kubwibyo, diludine ikwiye ifite ingaruka zo guteza imbere synthesis yumuhondo w amagi.

 

Imbonerahamwe 3 Ingaruka za diludine kumiterere yamagi

Umubare wa diludine ugomba kongerwamo (mg / kg)
Ubwiza bw'amagi	0	100	150	200
Igipimo cyerekana amagi (%)
Amagi uburemere bwihariye (g / cm3)
Uburemere bugereranije bw'igikonoshwa cy'amagi (%)
Umubyimba w'igikonoshwa cy'amagi (mm)
Igice cya Haugh (U)
Amagi yumuhondo (%)
Cholesterol y'umuhondo w'igi (%)
Uburemere bugereranije n'umuhondo w'igi (%)

 

2.3 Ingaruka ku ijanisha ryibinure byo munda nibirimo amavuta yumwijima yinkoko zitera

Reba Ishusho 1 na Igishushanyo cya 2 ku ngaruka za diludine ku ijanisha ry’ibinure byo munda hamwe n’ibinure byumwijima byinkoko zitera;

 

 

 

Igicapo 1 Ingaruka ya diludine ku ijanisha ryibinure byinda (PAF) yinkoko zitera

 

	Ijanisha ryibinure byo munda
	Umubare wa diludine ugomba kongerwamo

 

 

Igishushanyo 2 Ingaruka za diludine ku binure byumwijima (LF) yinkoko

	Ibinure byumwijima
	Umubare wa diludine ugomba kongerwamo

Urebye ku gishushanyo cya 1, ijanisha ryamavuta yo munda yitsinda ryipimishije ryaragabanutse kuri 8.3% na 12.11% (p <0.05) mugihe 100 na 150mg / kg ya diludine ugereranije nitsinda ryerekanwe, kandi ijanisha ryamavuta yo munda rigabanuka kuri 33.49% (p <0.01) iyo 200mg / kg ya diludine yongeyeho.Urebye ku gishushanyo cya 2, ibinure byumwijima (byumye rwose) bitunganijwe na 100, 150, 200mg / kg ya diludine bikagabanuka kuri 15.00% (p <0.05), 15.62% (p <0.05) na 27.7% (p < 0.01) ugereranije nitsinda ryerekanwe;kubwibyo rero, diludine igira ingaruka zo kugabanya ijanisha ryamavuta yo munda hamwe namavuta yumwijima yibirimo, biragaragara ko aho ari byiza iyo hiyongereyeho 200mg / kg ya diludine.

2.4 Ingaruka kuri serumu ya biohimiki

Urebye ku mbonerahamwe ya 4, itandukaniro riri mu bice byatunganijwe mu cyiciro cya I (30d) cy’ikizamini cya SOD ntirigaragara, kandi indangagaciro ya biohimiki ya serumu yibice byose aho diludine yongewemo mu cyiciro cya II (80d) yikizamini kiri hejuru kuruta itsinda ryerekanwe (p <0.05).Acide ya uric (p <0.05) muri serumu irashobora kugabanuka mugihe hiyongereyeho 150mg / kg na 200mg / kg ya diludine;mugihe ingaruka (p <0.05) iraboneka mugihe 100mg / kg ya diludine yongewe mugice cya I. Diludine irashobora kugabanya triglyceride muri serumu, aho ingaruka ari nziza (p <0.01) mumatsinda mugihe 150mg / kg ya diludine yongewemo mugice cya I, kandi nibyiza mumatsinda mugihe 200mg / kg ya diludine yongewe mugice cya II.Cholesterol yuzuye muri serumu iragabanuka hamwe no kongera diludine yongewe kumirire ya buri munsi, cyane cyane ibiri muri cholesterol yuzuye muri serumu bigabanuka kuri 36.36% (p <0.01) na 40,74% (p <0.01) mugihe 150mg / kg na 200mg / kg ya diludine yongewe mu cyiciro cya I ugereranije nitsinda ryerekanwe, kandi igabanuka kuri 26.60% (p <0.01), 37.40% (p <0.01) na 46.66% (p <0.01) mugihe 100mg / kg, 150mg / kg na 200mg / kg ya diludine byongewe mu cyiciro cya II ugereranije nitsinda ryerekanwe.Byongeye kandi, ALP yiyongereye hamwe no kongera diludine yongewe kumirire ya buri munsi, mugihe indangagaciro za ALP mumatsinda zongeweho 150mg / kg na 200mg / kg ya diludine zirenze izitsinda (p <0.05) biragaragara.

Imbonerahamwe 4 Ingaruka za diludine kubipimo bya serumu

Ingano ya diludine igomba kongerwaho (mg / kg) mu cyiciro cya I (30d) yikizamini
Ingingo	0	100	150	200
Superoxide gusenya (mg / mL)
Acide Uric
Triglyceride (mmol / L)
Lipase (U / L)
Cholesterol (mg / dL)
Glutamic-pyruvic transaminase (U / L)
Glutamic-oxalacetic transaminase (U / L)
Fosifata ya alkaline (mmol / L)
Kalisiyumu ion (mmol / L)
Fosifore idasanzwe (mg / dL)

 

Umubare wa diludine ugomba kongerwaho (mg / kg) mu cyiciro cya II (80d) yikizamini
Ingingo	0	100	150	200
Superoxide gusenya (mg / mL)
Acide Uric
Triglyceride (mmol / L)
Lipase (U / L)
Cholesterol (mg / dL)
Glutamic-pyruvic transaminase (U / L)
Glutamic-oxalacetic transaminase (U / L)
Fosifata ya alkaline (mmol / L)
Kalisiyumu ion (mmol / L)
Fosifore idasanzwe (mg / dL)

 

3 Isesengura n'ibiganiro

3.1. albumen yamagi yera na proteine ​​yumuhondo w amagi.Byongeye, ibirimo aside irike muri serumu byagabanutse bigaragara;kandi muri rusange byari byemewe ko igabanywa rya azote idafite poroteyine muri serumu bivuze ko umuvuduko wa catabolisme ya poroteyine wagabanutse, kandi igihe cyo kugumana azote cyarasubitswe.Igisubizo cyatanze ishingiro ryo kongera intungamubiri za poroteyine, guteza imbere gutera amagi no kuzamura uburemere bw amagi yinkoko zitera.Ibisubizo by'ikizamini byagaragaje ko ingaruka zo gushyira ari nziza mugihe hiyongereyeho 150mg / kg ya diludine, ibyo bikaba byari bihuye neza n'ibisubizo^[6,7]ya Bao Erqing na Qin Shangzhi kandi baguze wongeyeho diludine mugihe cyanyuma cyo gutera inkoko.Ingaruka zaragabanutse mugihe ingano ya diludine irenga 150mg / kg, bishobora kuba biterwa nuko poroteyine ihinduka^[8]yagize ingaruka kubera dosiye ikabije nuburemere bukabije bwa metabolism yumubiri kuri diludine.

3.2 Ubwinshi bwa Ca.²⁺muri serumu yamagi yagabanutse, P muri serumu yagabanutse mugitangira kandi ibikorwa bya ALP byariyongereye bigaragara imbere ya diludine, byagaragazaga ko diludine yagize ingaruka kuri metabolism ya Ca na P bigaragara.Yue Wenbin yatangaje ko diludine ishobora guteza imbere kwinjiza^[9] by'amabuye y'agaciro Fe na Zn;ALP yabayeho cyane mubice, nk'umwijima, igufwa, inzira y'amara, impyiko, nibindi.;ALP muri serumu yavaga mu mwijima no mu magufa cyane;ALP mu magufa yabayeho muri osteoblast cyane kandi yashoboraga guhuza ion ya fosifate na Ca2 kuva muri serumu nyuma yo guhinduka mugutezimbere kwangirika kwa fosifate no kongera ubukana bwa ion ya fosifate, hanyuma igashyirwa kumagufwa muburyo bwa hydroxyapatite, nibindi. . Kugirango bigabanye kugabanuka kwa Ca na P muri serumu, ibyo bikaba bihujwe no kongera umubyimba w amagi hamwe nuburemere ugereranije nigikonoshwa cy amagi mubipimo byubwiza bwamagi.Byongeye kandi, igipimo cy amagi yamenetse hamwe nijanisha ryamagi adasanzwe yagabanutse kuburyo bugaragara ukurikije imikorere yo gutera, nayo yasobanuye iyi ngingo.

3.3 Ibinure byo munda hamwe nibinure byumwijima byinkoko zaragabanutse byagaragaye bigaragara ko wongeyeho diludine mumirire, byagaragazaga ko diludine yagize ingaruka zo kubuza synthesis yamavuta mumubiri.Byongeye, diludine irashobora kunoza ibikorwa bya lipase muri serumu mugihe cyambere;ibikorwa bya lipase byariyongereye bigaragara mumatsinda yongewemo 100mg / kg ya diludine, kandi ibiri muri triglyceride na cholesterol muri serumu byagabanutse (p <0.01), byerekanaga ko diludine ishobora guteza imbere kwangirika kwa triglyceride kandi wirinde synthesis ya cholesterol.Ibinure bishobora kubuzwa kubera ko enzyme ya metabolisme ya lipide mu mwijima^[10,11], no kugabanya cholesterol mu muhondo w'igi nabyo byasobanuye iyi ngingo [13].Chen Jufang yatangaje ko diludine ishobora kubuza ibinure mu nyamaswa no kuzamura ijanisha ry’inyama za broilers n'ingurube, kandi bikagira ingaruka zo kuvura umwijima w'amavuta.Ibyavuye mu kizamini byasobanuye neza ubwo buryo bwo gukora, kandi ibisubizo byo gutandukanya no kwitegereza inkoko zipimishije na byo byagaragaje ko diludine ishobora kugabanya umuvuduko w’umwijima w’amavuta y’inkoko zitera bigaragara.

3.4 GPT na GOT ni ibimenyetso bibiri byingenzi byerekana imikorere yumwijima numutima, kandi umwijima numutima birashobora kwangirika niba ibikorwa byayo ari byinshi cyane.Ibikorwa bya GPT na GOT muri serumu ntabwo byahinduwe bigaragara mugihe diludine yongewe mubizamini, byerekanaga ko umwijima numutima bitangiritse;ikindi, ibisubizo byo gupima SOD byerekanaga ko ibikorwa bya SOD muri serumu bishobora kunozwa bigaragara mugihe diludine yakoreshejwe mugihe runaka.SOD bivuga scavenger nyamukuru ya superoxide radical radical mumubiri;ni ingirakamaro mu gukomeza ubusugire bw’ibinyabuzima, kuzamura ubushobozi bw’ubudahangarwa bw’ibinyabuzima no kubungabunga ubuzima bw’inyamaswa iyo ibirimo SOD mu mubiri byiyongereye.Quh Hai, nibindi byatangaje ko diludine ishobora kunoza imikorere ya 6-glucose fosifate dehydrogenase muri membrane yibinyabuzima kandi igahindura ingirangingo [2] zingirabuzimafatizo.Sniedze yerekanye ko diludine yabujije ibikorwa [4] bya NADPH cytochrome C reductase bigaragara ko nyuma yo kwiga isano iri hagati ya diludine na enzyme ijyanye na NADPH yihariye yohereza electron muri microsome yumwijima.Odydents yerekanye kandi ko diludine yari ifitanye isano na sisitemu ya oxydease hamwe na enzyme ya microsomal ifitanye isano na NADPH;nuburyo bwibikorwa bya diludine nyuma yo kwinjira mubikoko ni ukugira uruhare mukurwanya okiside no kurinda ibinyabuzima [8] muguhagarika ibikorwa byo kohereza electron ya enzyme ya NADPH ya microsome no kubuza inzira ya peroxidisation ya lipide.Ibisubizo by'ibizamini byagaragaje ko ibikorwa byo kurinda diludine kugeza ku binyabuzima biva ku mpinduka z’ibikorwa bya SOD bihinduka mu bikorwa bya GPT na GOT kandi byerekana ibyavuye mu bushakashatsi bwa Sniedze na Odydents.

 

Reba

1 Zhou Kai, Zhou Mingjie, Qin Zhongzhi, nibindi. Kwiga kuri diludine yo kunoza imikorere yimyororokere yintamaJ. Ibyatsi naLivestock 1994 (2): 16-17

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