Ukuzala kunye nokuphuculwa kweehagu zangoku kwenziwa ngokweemfuno zabantu.Injongo kukwenza iihagu zitye kancinci, zikhule ngokukhawuleza, zivelise kakhulu kwaye zibenezinga eliphezulu lenyama ebhityileyo.Kunzima ukuba indawo yendalo ihlangabezane nezi mfuno, ngoko ke kuyimfuneko ukwenza kakuhle kwindawo yokwenziwa!

Ukupholisa kunye nokugcinwa kobushushu, ulawulo lokufuma okomileyo, inkqubo yogutyulo, umgangatho womoya kwindlu yemfuyo, inkqubo yezothutho, inkqubo yokutya, umgangatho wezixhobo, ulawulo lwemveliso, ukutya kunye nesondlo, iteknoloji yokuzala njalo njalo zonke zichaphazela ukusebenza kwemveliso kunye nesimo sezempilo. iihagu.

Imeko yangoku esijongene nayo yeyokuba ziya zisanda iindyikityha zehagu, izitofu zokugonya kunye namachiza onyango lwezilwanyana ziya zisanda, kwaye kuya kuba nzima ukufuya iihagu.Iifama ezininzi zeehagu azikabi nangeniso okanye ilahleko xa imarike yeehagu ifikelele kwirekhodi eliphezulu kwaye yahlala ixesha elide.

Emva koko asikwazi ukuzibamba kodwa sijonge ukuba ingaba indlela yangoku yokujongana nesifo sobhubhane wehagu ichanekile na okanye indlela echanekileyo.Kufuneka sijonge oonobangela besi sifo kwishishini leehagu.Ngaba kungenxa yokuba intsholongwane kunye neebhaktheriya zomelele kakhulu okanye umgaqo-siseko weehagu ubuthathaka kakhulu?

Ngoko ngoku i-industry ihlawula ingqalelo ngakumbi nangakumbi kwi-non-specific immune function yeehagu!

Izinto ezichaphazela umsebenzi wokhuselo lomzimba wehagu:

1. Isondlo

Kwinkqubo yosulelo lwe-pathogenic, amajoni omzimba wezilwanyana ayasebenza, umzimba udibanisa inani elikhulu le-cytokines, izinto zeekhemikhali, iiprotheyini zenqanaba elibukhali, amajoni omzimba, njl. ubushushu bomzimba buyanda, nto leyo ifuna izondlo ezininzi.

Okokuqala, inani elikhulu lama-amino acids liyadingeka ukudibanisa iiprotheni, ii-antibodies kunye nezinye izinto ezisebenzayo kwisigaba esinzima, okubangelwa ukulahleka kweprotheni yomzimba kunye nokukhutshwa kwe-nitrogen.Kwinkqubo yosulelo lwe-pathogenic, ukunikezelwa kwee-amino acids ubukhulu becala kuvela ekuthotyweni kweprotheyini yomzimba kuba ukutya kunye nokutya kwezilwanyana kuncitshiswe kakhulu okanye kuzilwe.Ukuphuculwa kwemetabolism kuya kwandisa imfuno yeevithamini kunye nokulandelela izinto.

Ngakolunye uhlangothi, umngeni wezifo ze-epidemic kubangela uxinzelelo lwe-oxidative kwizilwanyana, ukuvelisa inani elikhulu lama-radicals amahhala kunye nokwandisa ukusetyenziswa kwe-antioxidants (VE, VC, Se, njl.).

Kumngeni wesifo sobhubhane, i-metabolism yezilwanyana iphuculwe, imfuno yezondlo iyandiswa, kwaye ukuhanjiswa kwezilwanyana zezilwanyana kuguqulwa ukusuka ekukhuleni ukuya ekukhuseleni.Ezi ntshukumo zemetabolism zezilwanyana kukumelana nezifo zendyikityha kwaye ziphile kangangoko, okusisiphumo senguquko yexesha elide okanye ukhetho lwendalo.Nangona kunjalo, phantsi kokhetho olwenziweyo, ipateni yemetabolism yeehagu kumngeni wesifo sikabhubhane iyaphambuka kwindlela yokhetho lwendalo.

Kwiminyaka yakutshanje, inkqubela phambili yokufuya iihagu iphucule kakhulu amandla okukhula kweehagu kunye nezinga lokukhula kwenyama ebhityileyo.Xa ezohagu zosulelekile, indlela yokusasaza izondlo ezifumanekayo iyatshintsha ukuya kwinqanaba elithile: izondlo ezabelwa amajoni omzimba ziyehla kwaye izondlo ezinikezelwe ekukhuleni ziyanda.

Phantsi kweemeko ezisempilweni, oku kuluncedo ngokwendalo ekuphuculeni ukusebenza kwemveliso (ukuzala kweehagu kuqhutywa phantsi kweemeko ezisempilweni kakhulu), kodwa xa kukho umngeni kwizifo zendyikityha, ezo hagu zinokukhuseleka okuphantsi kunye nokufa okuphezulu kuneentlobo zakudala (iihagu zasekhaya e-China zikhula ngokucothayo; kodwa ukuxhathisa kwabo kwezifo kuphezulu kakhulu kuneehagu zasemzini zangoku).

Ukugxila okuqhubekayo ekukhethweni kokuphucula ukusebenza kokukhula kuye kwatshintsha ngokwemfuza ukuhanjiswa kwezondlo, ekufuneka zincame imisebenzi ngaphandle kokukhula.Ngoko ke, ukufuya iihagu ezibhityileyo ezinesakhono esiphezulu semveliso kufuneka kunikeze umgangatho ophezulu wesondlo, ingakumbi kumcelimngeni wezifo ezingubhubhani, ukuze kuqinisekiswe ukubonelelwa ngesondlo, ukuze zibenezakhamzimba ezaneleyo zokugonywa, kwaye iihagu zikwazi ukoyisa izifo zobhubhane.

Kwimeko yokufuywa kweehagu okuphantsi okanye ubunzima bezoqoqosho kwiifama zeehagu, nciphisa ukutya kweehagu.Xa ubhubhane uhlasela, imiphumo isenokuba yintlekele.

2. Uxinzelelo

Uxinzelelo lutshabalalisa ubume behagu kwaye kwandisa ingozi yokosuleleka kwiihagu.

Uxinzelelokukhokelela ekwandeni kwe-oxygen free radicals kwaye kutshabalalisa ukugqithiswa kwe-membrane yeseli.I-permeability ye-membrane yeseli yanda, eyayinceda kakhulu ekungeneni kweebhaktheriya kwiiseli;Ukuxinezeleka kukhokelela ekuvuseleleni inkqubo ye-adrenal medullary enovelwano, ukunyanzeliswa okuqhubekayo kwemikhumbi ye-visceral, i-mucosal ischemia, ukulimala kwe-hypoxic, ukuguguleka kwesilonda;Uxinzelelo lukhokelela kukuphazamiseka kwemetabolism, ukwanda kwe-intracellular acidic kunye nomonakalo we-mucosal obangelwa yi-acidosis yeselula;Uxinzelelo lukhokelela ekukhuselweni kweglucocorticoid kunye neglucocorticoid inqanda ukuvuselelwa kweseli ye-mucosal.

Uxinzelelo lonyusa umngcipheko wokukhutshwa kwetyhefu kwiihagu.

Izinto ezahlukeneyo zoxinzelelo zibangela ukuba umzimba uvelise inani elikhulu le-oxygen free radicals, eyonakalisa iiseli ze-vascular endothelial, ifake i-intravascular granulocyte aggregation, ikhawulezise ukwakheka kwe-microthrombosis kunye nomonakalo weseli endothelial, iququzelele ukusasazeka kwentsholongwane, kunye nokwandisa umngcipheko wokukhupha.

Uxinzelelo lwehlisa ukuxhathisa komzimba kwaye kwandisa ingozi yokungazinzi kweehagu.

Ngakolunye uhlangothi, ukulawulwa kwe-endocrine ngexesha loxinzelelo kuya kuthintela isistim somzimba, njenge-glucocorticoid inempembelelo yokuthintela ekusebenzeni komzimba;Ngakolunye uhlangothi, ukwanda kwe-oxygen free radicals kunye ne-pro-inflammatory factor ebangelwa uxinzelelo luya kuwonakalisa ngokuthe ngqo iiseli ze-immune, okukhokelela ekunciphiseni inani leeseli zomzimba kunye nokungaphumeleli kwe-interferon, okubangelwa ukunyanzeliswa kwe-immunosuppression.

Ukubonakaliswa okuthe ngqo kokuhla kwe-immune engabonakaliyo:

● ilindle lamehlo, amachaphaza, ukopha emqolo nezinye iingxaki ezintathu ezimdaka

Ukopha ngasemva, ulusu oludala kunye nezinye iingxaki zibonisa ukuba amajoni omzimba wokuqala, umphezulu womzimba kunye nomqobo we-mucosal wonakalisiwe, okukhokelela ekungeneni lula kweentsholongwane emzimbeni.

Undoqo we-lacrimal plaque yeyokuba idlala lengqula lisoloko likhupha iinyembezi ukuthintela ukosuleleka ngakumbi kweentsholongwane nge-lysozyme.I-Lacrimal plaque ibonisa ukuba umsebenzi we-mucosal immune barrier kwi-ocular surface iyancitshiswa, kwaye i-pathogen ayizange isuswe ngokupheleleyo.Kwakhona kwabonisa ukuba enye okanye ezimbini ze-SIgA kunye neeprotheni ezincedisayo kwi-ocular mucosa zazingonelanga.

● hlwayela ukuthotywa kokusebenza

Izinga lokupheliswa kweemazi eziziimazi liphezulu kakhulu, iimazi ezimithiyo ziyaphunza, zizale iimazi ezifileyo, iimazi, amantshontsho eehagu abuthathaka, njl njl;

Ixesha elide le-estrous kunye nokubuyela kwi-estrus emva kokulunyulwa;Umgangatho wobisi lwemazi ezincancisayo wehla, ukungakhuseleki kwamantshontsho asandula kuzalwa bekungekho nto, imveliso yayicotha, kwaye nesantya sorhudo sasiphezulu.

Kukho inkqubo ye-mucosal kuzo zonke iindawo ze-mucosal zehagu, kubandakanywa ibele, i-digestive tract, i-uterus, i-reproductive tract, i-renal tubules, i-skin glands kunye nezinye i-submucosa, enomsebenzi omninzi we-immune barrier ukuthintela usulelo lwe-pathogen.

Thatha iliso njengomzekelo:

① I-ocular epithelial cell membrane kunye ne-lipid efihliweyo kunye nezixhobo zamanzi zenza umqobo womzimba kwi-pathogens.

②I-antibacterialamacandelo akhutshwa ngamadlala kwi-epithelium ye-ocular mucosal, njengeenyembezi ezikhutshwa ngamadlala e-lacrimal, ziqulethe inani elikhulu le-lysozyme, enokubulala iibhaktheriya kwaye inqanda ukuveliswa kwebhaktheriya, kwaye yenze umqobo wekhemikhali kwi-pathogens.

③ I-Macrophages kunye neeseli ze-NK zokubulala zendalo ezisasazwa kwi-tissue fluid ye-mucosal epithelial cell can phagocytize pathogens kwaye isuse iiseli ezosulelwe yi-pathogens, zenze umqobo we-immune cell.

④ I-immunity ye-mucosal yasekhaya yenziwe yi-immunoglobulin SIgA efihliweyo ngeeseli ze-plasma ezisasazwa kwi-tissue edibeneyo ye-subepithelial layer ye-ocular mucosa kunye neprotheni ehambelanayo ehambelana nobuninzi bayo.

Indawoukukhuseleka kwe-mucosalidlala indima ebalulekileyo kwiukukhusela umzimba, ekugqibeleni inokuphelisa i-pathogens, ikhuthaze ukubuyiswa kwempilo kunye nokukhusela ukusuleleka ngokuphindaphindiweyo.

Ulusu oludala kunye namabala okukrazula kweemazi kubonisa umonakalo wokugonywa kwe-mucosal jikelele!

Umgaqo: ukutya okunokulinganisela kunye nesiseko esiqinileyo;Ukukhuselwa kwesibindi kunye ne-detoxification ukuphucula impilo;Ukunciphisa uxinzelelo kunye nokuzinzisa indawo yangaphakathi;Ugonyo olufanelekileyo lokuthintela izifo zentsholongwane.

Kutheni sincamathela ukubaluleka ekukhuselweni kwesibindi kunye ne-detoxification ekuphuculeni ukungatheleleki okuthe ngqo?

Isibindi sesinye samalungu okhuselo lokhuselo lomzimba.Iiseli ze-innate immune ezifana ne-macrophages, i-NK kunye neeseli ze-NKT zezona zininzi esibindini.I-Macrophages kunye ne-lymphocytes esibindini zingundoqo kwi-immunity yeselula kunye ne-humoral immunity ngokulandelanayo!Ikwayiseli esisiseko ye-nonspecific immunity!Amashumi amathandathu ekhulwini ee-macrophage kuwo wonke umzimba aqokelelana esibindini.Emva kokungena esibindini, ininzi ye-antigens evela emathunjini iya kuginywa kwaye ihlanjululwe yi-macrophages (iiseli ze-Kupffer) esibindi, kwaye inxalenye encinci iya kuhlanjululwa yintso;Ukongeza, uninzi lweentsholongwane, ii-antigen antibody complexes kunye nezinye izinto ezinobungozi kwi-blood circulation ziya kuginywa kwaye zicocwe ngamaseli e-Kupffer ukukhusela ezi zinto ziyingozi ekulimazeni umzimba.Inkunkuma yetyhefu ecocwa sisibindi kufuneka ikhutshwe kwinyongo iye emathunjini, emva koko ikhutshwe emzimbeni ngamalindle.

Njengeziko lenguqu yemetabolism yezondlo, isibindi sidlala indima engenakuthathelwa indawo kutshintsho olugudileyo lwezondlo!

Phantsi koxinzelelo, iihagu ziyakwandisa imetabolism kwaye ziphucule isakhono sokulwa noxinzelelo lweehagu.Kule nkqubo, iiradicals zasimahla kwiihagu ziya kwanda kakhulu, nto leyo izakunyusa umthwalo weehagu kwaye ikhokelele ekwehleni kokhuselo lomzimba.Ukuveliswa kwee-radicals zamahhala kuhambelana ngokuqinisekileyo kunye nokuqina kwe-metabolism yamandla, oko kukuthi, ukuqina kwe-metabolism yomzimba, i-radicals yamahhala iya kuveliswa.Okona kunamandla ngakumbi i-metabolism yamalungu, kulula kwaye yomelele ngakumbi iya kuhlaselwa ngama-radicals asimahla.Ngokomzekelo, isibindi siqulethe iindidi zee-enzymes, ezithatha inxaxheba kuphela kwi-metabolism ye-carbohydrates, iiprotheni, amafutha, iivithamini kunye namahomoni, kodwa zinemisebenzi yokukhupha, ukukhupha, ukukhupha, ukubola kunye nokugonywa.Ivelisa ngakumbi iiradicals zasimahla kwaye iyingozi ngakumbi ngeeradicals zasimahla.

Ngoko ke, ukuphucula ukungatheleleki okuthe ngqo, kufuneka sinikele ingqalelo ekukhuselweni kwesibindi kunye nokukhupha i-toxification yeehagu!