Ma antibiotic osiyanasiyana pakupanga nkhuku akuletsedwa pang'onopang'ono padziko lonse lapansi chifukwa cha zovuta zomwe zimaphatikizapo zotsalira za ma antibiotic komanso kukana kwa ma antibiotic.Tributyrin inali njira ina yopangira maantibayotiki.Zotsatira za kafukufuku wapano zawonetsa kuti tributyrin imatha kupititsa patsogolo kukula kwake posintha magawo amagazi am'magazi komanso mawonekedwe a cecal microflora a broilers achikasu.Monga momwe tikudziwira, kafukufuku wochepa adafufuza zotsatira za tributyrin pamatumbo a microbiota komanso ubale wake ndi kukula kwa nkhuku.Izi zipereka maziko asayansi ogwiritsira ntchito tributyrin pakuweta ziweto m'nthawi ino ya pambuyo pa mankhwala opha tizilombo.

Butyric acid amapangidwa mkati mwa lumen yamatumbo a nyama ndi kuwira kwa bakiteriya kwa chakudya chosagawika chazakudya komanso mapuloteni amkati.90% ya butyric acid iyi imapangidwa ndi maselo a cecal epithelial kapena colonocytes kuti apereke zopindulitsa zingapo paumoyo wamatumbo.

Komabe, asidi waulere wa butyric ali ndi fungo loyipa ndipo ndizovuta kuchita nawo.Kuphatikiza apo, ma acid aulere a butyric awonetsedwa kuti amalowetsedwa kwambiri m'matumbo am'mimba, zomwe zimapangitsa kuti ambiri asafike m'matumbo akulu, pomwe butyric acid imagwira ntchito yake yayikulu.

Chifukwa chake, malonda amchere a sodium butyrate adapangidwa kuti azitha kuwongolera ndikuletsa kutulutsa kwa butyric acid kumtunda kwa m'mimba.

Koma tributyrin imakhala ndi butyric acid ndi mono-butyrin komanso m'matumbo a m'mimba, tributyrin imapangidwa ndi hydrolzed kukhala butyric acid ndi α-mono-butyrin koma mu hindgut, molekyulu yayikulu idzakhala α-monobutyrin yomwe imapereka mphamvu zambiri, kulimbikitsa kukula kwa minofu ndikulimbikitsa kukula kwa capillary kuti muyendetse bwino zakudya.

Pali zovuta zingapo zomwe zimakhudzana ndi thanzi lamatumbo a nkhuku kuphatikiza:

• kutsekula m'mimba
• malabsorption syndrome
• coccidiosis
• necrotic enteritis

Kuphatikiza kwa tributyrin kwagwiritsidwa ntchito kwambiri kuthana ndi vuto la m'matumbo, ndipo pamapeto pake kumapangitsa thanzi lamatumbo a nkhuku.

Mu nkhuku zosanjikizana, zimatha kusintha mayamwidwe a kashiamu makamaka mu nkhuku zazikulu zoikira ndikusintha chigoba cha dzira.

Kusintha kwa ana a nkhumba kuyamwa ndi nthawi yovuta kwambiri chifukwa cha kupsyinjika kwakukulu komwe kumachitika chifukwa cha kusamuka kuchoka ku madzi kupita ku chakudya cholimba, kusintha kwa chilengedwe, ndi kusakanikirana ndi zibwenzi zatsopano.

M'mayesero aposachedwa a ana a nkhumba omwe tidachita ku Rivalea, zikuwonekeratu kuti kuwonjezera 2.5 kg Tributyrin / MT pambuyo poyamwitsa zakudya kwa masiku 35 kumapangitsa kuti thupi liwonjezeke ndi 5% komanso kusintha kwakusintha kwa chakudya ndi mfundo zitatu.

Tributyrin itha kugwiritsidwanso ntchito mkaka monga cholowa m'malo mwa mkaka wathunthu ndipo pang'ono amatsutsa zotsatira zoyipa zomwe zolowa m'malo mkaka zimakhala nazo pakukula kwa rumen.