Imikhiqizo ehlukahlukene yama-antibiotic ekukhiqizeni izinkukhu iyavinjelwa kancane kancane emhlabeni jikelele ngenxa yezinkinga ezimbi ezihlanganisa izinsalela zama-antibiotic kanye nokungazweli kwama-antibiotic.I-Tributyrin yayingase ibe enye indlela yama-antibiotics.Imiphumela yocwaningo lwamanje ibonise ukuthi i-tributyrin ingathuthukisa ukusebenza kokukhula ngokushintsha izinkomba ze-biochemical yegazi kanye nokwakheka kwe-cecal microflora yama-broilers anezimpaphe eziphuzi.Ngokwazi kwethu konke, izifundo ezimbalwa ziphenye imiphumela ye-tributyrin ku-intestinal microbiota kanye nobudlelwano bayo nokusebenza kokukhula kwezinkukhu.Lokhu kuzohlinzeka ngesisekelo sesayensi sokusetshenziswa kwe-tributyrin ekufuyweni kwezilwane kule nkathi yangemva kokukhishwa kwama-antibiotic.

I-Butyric acid ikhiqizwa ngaphakathi kwe-lumen yamathumbu esilwane ngokuvutshelwa kwebhaktheriya kwama-carbohydrate angagayeki okudla kanye namaprotheni angapheli.I-90% yale asidi ye-butyric yenziwa i-metabolism ngamaseli e-cecal epithelial noma ama-colonocyte ukuze anikeze imiphumela enenzuzo eminingi empilweni yamathumbu.

Kodwa-ke, i-butyric acid yamahhala inephunga elibi futhi kunzima ukuyiphatha ngokusebenza.Ukwengeza, ama-asidi amahhala e-butyric aboniswe ukuthi amuncwa kakhulu endaweni engaphezulu ye-gastro-intestinal tract, okuholela ekutheni iningi lingafinyeleli emathunjini amakhulu, lapho i-butyric acid izosebenzisa umsebenzi wayo omkhulu.

Ngakho-ke, i-butyrate ye-sodium ye-salt butyrate yezentengiselwano yenziwe ukuze kube lula ukuphatha futhi kuvimbele ukukhululwa kwe-butyric acid endaweni engenhla ye-gastro-intestinal.

Kodwa i-tributyrin iqukethe i-butyric acid kanye ne-mono-butyrin futhi endaweni engenhla ye-gastro-intestinal tract, i-tributyrin i-hydrolzed ibe yi-butyric acid ne-α-mono-butyrin kodwa ku-hindgut, i-molecule enkulu izoba i-α-monobutyrin ehlinzeka amandla engeziwe, ukuze kuthuthukisa ukukhula kwemisipha futhi kukhuthaze ukuthuthukiswa kwe-capillary ukuze kube ngcono ukuhamba kwezakhi.

Kunezifo eziningi ezihambisana nempilo yamathumbu ezinkukhu okuhlanganisa:

• isifo sohudo
• i-malabsorption syndrome
• i-coccidiosis
• i-necrotic enteritis

Ukwengezwa kwe-tributyrin sekusetshenziswe kabanzi ukulwa nokuphazamiseka kwamathumbu, futhi ekugcineni kuthuthukise impilo yamathumbu enkukhu.

Ezikhukhukazini zenkukhu eziwugqinsi, iyakwazi ukwenza ngcono ukumuncwa kwe-calcium ikakhulukazi ezikhukwini ezizalelayo ezindala futhi ithuthukise ikhwalithi yegobolondo lamaqanda.

Emazinyaneni engulube ukuguquka kokulunyulwa kuyinkathi ebucayi ngenxa yokucindezeleka okukhulu okuvela ekushintsheni kusuka kuketshezi kuya kokuphakelayo okuqinile, ukushintsha indawo ezungezile, kanye nokuxubana nabalingani abasha bepeni.

Ocwaningweni lwakamuva lwezingulube zengulube esilwenzile e-Rivalea, kuboniswa ngokusobala ukuthi ukwengeza ukudla okuwu-2.5 kg we-Tributyrin/MT ngemva kokulunyulwa kwezinsuku ezingu-35 kuthuthukisa ukuzuza kwesisindo somzimba ngo-5% kanye nesilinganiso sokuguqulwa kokuphakelayo ngamaphoyinti angu-3.

I-Tributyrin ingasetshenziswa futhi obisini esikhundleni sobisi oluphelele futhi kancane ingawunaki umthelela omubi okwenziwa esikhundleni sobisi ekuthuthukisweni kwe-rumen.