Iimveliso ezahlukeneyo zamayeza okubulala iintsholongwane kwimveliso yeenkukhu ziye zayekiswa kancinci kancinci kwihlabathi jikelele ngenxa yeengxaki ezingalunganga ezibandakanya iintsalela ze-antibiotic kunye nokuxhathisa amayeza.I-Tributyrin yayiyenye into enokuthi ibekho kwi-antibiotics.Iziphumo zophononongo lwangoku zibonise ukuba i-tributyrin inokuphucula ukukhula kokukhula ngokumodareyitha izalathisi ze-biochemical yegazi kunye nokwakheka kwe-cecal microflora yeebroilers ezineentsiba ezityheli.Ngokolwazi lwethu, izifundo ezimbalwa ziye zaphanda iziphumo ze-tributyrin kwi-intestinal microbiota kunye nobudlelwane bayo kunye nokusebenza kokukhula kweenkukhu.Oku kuya kubonelela ngesiseko senzululwazi sokusetyenziswa kwe-tributyrin ekufuyweni kwezilwanyana kweli xesha le-antibiotics.

Iasidi yeButyric iveliswa ngaphakathi kwilumen yamathumbu esilwanyana ngokubiliswa kwebhaktheriya yeekhabhohayidrethi zokutya ezingagatywanga kunye neeproteni ezingapheliyo.I-90% yale asidi ye-butyric i-metabolized ngamaseli e-cecal epithelial okanye i-colonocytes ukubonelela ngemiphumo emihle emininzi kwimpilo yamathumbu.

Nangona kunjalo, i-asidi ye-butyric yamahhala inevumba elibi kwaye kunzima ukuyiphatha ekusebenzeni.Ukongezelela, i-asidi ye-butyric yamahhala ibonakaliswe ukuba ifakwe kakhulu kwi-gastro-intestinal tract, ebangela ukuba uninzi lungafikeleli emathunjini amakhulu, apho i-butyric acid iya kwenza umsebenzi wayo omkhulu.

Ke ngoko, i-butyrate yetyuwa yesodium yentengiso iye yaphuhliswa ukuze kube lula ukuphatha kunye nokuthintela ukukhutshwa kweasidi ye-butyric kwindawo ephezulu ye-gastro-intestinal.

Kodwa i-tributyrin iqulethe i-asidi ye-butyric kunye ne-mono-butyrin kwaye kwindawo ephezulu ye-gastro-intestinal tract, i-tributyrin i-hydrolzed ibe yi-butyric acid kunye ne-α-mono-butyrin kodwa kwi-hindgut, i-molecule enkulu iya kuba yi-α-monobutyrin enika amandla amaninzi, ukwandisa ukukhula kwezihlunu kunye nokukhuthaza ukukhula kwe-capillary ukwenzela ukuthutha izondlo ezingcono.

Kukho inani lezifo ezinxulumene nempilo yamathumbu enkukhu kuquka:

• urhudo
• i-malabsorption syndrome
• i-coccidiosis
• ukuvuvukala kwe-necrotic enteritis

Ukongezwa kwe-tributyrin kusetyenziswe ngokubanzi ukulwa ukuphazamiseka kwamathumbu, kwaye ekugqibeleni komeleza impilo yamathumbu enkukhu.

Kumaleko enkukhu zenkukhu, iyakwazi ukuphucula ukufunxwa kwecalcium ngakumbi kwinkukhu ezizalelayo ezindala kwaye iphucule umgangatho wamaqokobhe eqanda.

Kumantshontsho eehagu inguqu yokulunyulwa lithuba elibalulekileyo ngenxa yoxinzelelo olumandla olubangelwa kukusuka kulwelo ukuya kwisondlo esiqinileyo, ukuguquka kwemekobume, kunye nokuxubana namaqabane amatsha.

Kulingo lwakutsha nje lwamantshontsho eehagu esilwenzile eRivalea, kuboniswa ngokucacileyo ukuba ukongeza i-2.5 kg ye-Tributyrin / MT emva kokulunyulwa kwesidlo kwiintsuku ezingama-35 kuphuculwe ukufumana ubunzima bomzimba nge-5% kunye nomlinganiselo wokuguqulwa kwesondlo ngamanqaku ama-3.

I-Tributyrin isenokusetyenziswa ebisini njengethathela indawo yobisi olupheleleyo kwaye iyayigatya ngokuyinxenye impembelelo engalunganga enokuthi ithathe indawo yobisi ekuphuhliseni irumen.