Pub additive: Tributyrin

Cov ntsiab lus: 95%, 90%

Tributyrin ua cov khoom noj ntxiv kom txhim kho plab hnyuv hauv cov nqaij qaib.

Phasing tawm ntawm cov tshuaj tua kab mob raws li kev txhawb nqa kev loj hlob los ntawm cov nqaij qaib pub zaub mov tau ua rau muaj kev txaus siab rau lwm txoj kev noj zaub mov zoo, rau ob qho tib si nce nqaij qaib kev ua tau zoo thiab tiv thaiv kab mob cuam tshuam.

Txo cov dysbacteriosis tsis xis nyob
Txhawm rau khaws cov kev kuaj mob dysbacteriosis, pub additives xws li probiotics thiab prebiotics raug ntxiv los cuam tshuam rau kev tsim cov SCFAs, tshwj xeeb tshaj yog butyric acid uas ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv txoj hnyuv.Butyric acid yog ib txwm tshwm sim SCFA uas muaj ntau yam txiaj ntsig zoo xws li nws cov tshuaj tiv thaiv kab mob, nws lub zog ua kom cov txheej txheem kho plab hnyuv thiab txhawb kev loj hlob ntawm plab villi.Muaj ib txoj hauv kev tshwj xeeb butyric acid ua los ntawm cov txheej txheem los tiv thaiv kev kis kab mob, uas yog Host Defense Peptides (HDPs) synthesis, tseem hu ua anti-microbial peptides, uas yog cov khoom tseem ceeb ntawm lub cev tiv thaiv kab mob.Lawv muaj dav-spectrum anti-microbial kev ua ub no tiv thaiv kab mob, fungi, parasites thiab enveloped viruses uas nyuaj heev rau pathogens los tiv thaiv tawm tsam.Defensins (AvBD9 & AvBD14) thiab Cathelicidins yog ob tsev neeg loj ntawm HDPs (Goitsuka li al.; Lynn li al.; Ganz li al.) pom nyob rau hauv cov nqaij qaib uas tau txais kev txhawb nqa los ntawm butyric acid supplementation.Hauv kev tshawb fawb los ntawm Sunkara thiab.al.exogenous kev tswj hwm ntawm butyric acid induces ib tug zoo kawg li nce nyob rau hauv HDP noob qhia thiab yog li txhim khu kev tiv thaiv kab mob muaj peev xwm nyob rau hauv qaib.Interestingly, nruab nrab thiab LCFAs marginal.

Cov txiaj ntsig kev noj qab haus huv ntawm Tributyrin
Tributyrin yog ib tug precursor ntawm butyric acid uas tso cai rau ntau molecules ntawm butyric acid xa mus rau hauv cov hnyuv me ncaj qha vim yog esterification technic.Yog li ntawd, cov concentrations yog ob mus rau peb lub sij hawm ntau dua li cov pa coated khoom.Esterification tso cai rau peb butyric acid molecules yuav tsum tau khi rau glycerol uas tsuas yog tawg los ntawm endogenous pancreatic lipase.
Li et.al.teeb tsa kev tshawb fawb txog kev tiv thaiv kab mob txhawm rau txhawm rau pom cov txiaj ntsig zoo ntawm tributyrin ntawm cov kab mob cytokines hauv broilers sib tw nrog LPS (lipopolysaccharide).Kev siv LPS tau lees paub dav dav kom ua rau muaj kev mob tshwm sim hauv kev tshawb fawb zoo li no vim nws ua rau cov cim inflammatory xws li IL (Interleukins).Nyob rau hnub 22, 24, thiab 26 ntawm qhov kev sim, broilers tau sib tw nrog kev tswj hwm intraperitoneal ntawm 500 μg / kg BW LPS lossis saline.Dietary tributyrin supplementation ntawm 500 mg / kg inhibited qhov nce ntawm IL-1β & IL-6 qhia tias nws cov supplementation muaj peev xwm txo tau cov kev tso tawm ntawm pro-inflammatory cytokines thiab yog li txo cov plab o.

Cov ntsiab lus
Nrog rau kev txwv tsis pub siv lossis ua tiav kev txwv tsis pub muaj qee yam tshuaj tua kab mob loj hlob raws li cov khoom noj ntxiv, cov tswv yim tshiab rau kev txhim kho thiab tiv thaiv kev noj qab haus huv ntawm cov tsiaj ua liaj ua teb yuav tsum tau tshawb nrhiav.Lub plab hnyuv siab ua haujlwm yog qhov tseem ceeb ntawm kev sib txuas ntawm cov khoom noj khoom haus kim thiab kev loj hlob ntawm broilers.Butyric acid tshwj xeeb yog lees paub tias yog lub zog muaj zog ntawm kev noj qab haus huv ntawm txoj hnyuv uas twb tau siv rau hauv cov tsiaj pub rau ntau tshaj 20 xyoo.Tributyrindelivers butyric acid nyob rau hauv cov hnyuv me thiab muaj txiaj ntsig zoo hauv kev cuam tshuam plab hnyuv noj qab haus huv los ntawm kev ua kom cov txheej txheem kho cov hnyuv, txhawb kev txhim kho villi zoo thiab hloov kho cov tshuaj tiv thaiv kab mob hauv cov hnyuv.

Tam sim no nrog cov tshuaj tua kab mob tau raug txiav tawm, butyric acid yog ib qho cuab yeej zoo los txhawb kev lag luam kom txo tau qhov cuam tshuam tsis zoo ntawm dysbacteriosis uas yog surfacing vim qhov kev hloov pauv no.