Kugaburira ibiryo: Tributyrin

Ibirimo: 95%, 90%

Tributyrin nk'inyongeramusaruro yo kuzana ubuzima bwiza bw'inkoko.

Guhagarika antibiyotike nk'abateza imbere gukura mu biryo by’inkoko byongereye inyungu ku zindi ngamba zita ku mirire, haba mu kongera imikorere y’inkoko kimwe no kwirinda ihungabana ry’indwara.

Kugabanya ikibazo cya dysbacteriose
Mu rwego rwo gukomeza kugenzura ibibazo bya dysbacteriose, hongerwaho inyongeramusaruro nka probiotics na prebiotics kugira ngo bigire ingaruka ku musaruro wa SCFAs, cyane cyane aside butyric igira uruhare runini mu kurinda ubusugire bw’amara.Acide Butyric ni bisanzwe bibaho SCFA ifite ingaruka zinyuranye zingirakamaro nkingaruka zayo zo kurwanya inflammatory, ingaruka zayo zo kwihutisha gusana amara no gutera imbere gukura kwa villi.Hariho uburyo budasanzwe aside aside ikora binyuze muburyo bwo kwirinda kwandura, aribyo synthesis ya Host Defence Peptides (HDPs), izwi kandi nka peptide irwanya mikorobe, ibyo bikaba ari bimwe mu bigize ubudahangarwa bw'umubiri.Bafite ibikorwa byinshi byo kurwanya mikorobe birwanya bagiteri, ibihumyo, parasite na virusi zipfunyitse bigoye cyane ko virusi itera imbaraga zo kurwanya.Defensins (AvBD9 & AvBD14) na Cathelicidine nimiryango ibiri yingenzi ya HDPs (Goitsuka et al.; Lynn et al .; Ganz et al.) Iboneka mu nkoko izamurwa no kongera aside aside.Mu bushakashatsi bwakozwe na Sunkara n'abandi.al.exogenous administration ya acide butyric itera kwiyongera gutangaje mumagambo ya HDP bityo bikongerera ubushobozi bwo kurwanya indwara mu nkoko.Igishimishije, iringaniye na LCFAs marginal.

Inyungu zubuzima bwa Tributyrin
Tributyrin ibanziriza acide butyric ituma molekile nyinshi za acide butyric zitangwa mumara mato bitaziguye kubera tekinike ya esterification.Kubwibyo, kwibandaho bikubye inshuro ebyiri kugeza kuri eshatu ugereranije nibicuruzwa bisanzwe.Esterification ituma molekile eshatu za butyric zihuza na glycerol zishobora kumeneka gusa na lipase ya endogenous pancreatic lipase.
Li n'abandi.al.shiraho ubushakashatsi bwikingira kugirango ubone ingaruka nziza za tributyrine kuri cytokine itera inflammatory muri broilers zirwanya LPS (lipopolysaccharide).Imikoreshereze ya LPS irazwi cyane kugirango itere umuriro mubushakashatsi nkubu kuva ikora ibimenyetso byerekana umuriro nka IL (Interleukins).Ku munsi wa 22, 24, na 26 wurubanza, broilers zamaganwe nubuyobozi bwa intraperitoneal ya 500 μg / kg BW LPS cyangwa saline.Indyo yuzuye ya tributyrin ya 500 mg / kg yabujije kwiyongera kwa IL-1β & IL-6 byerekana ko iyongerwaho ryayo rishobora kugabanya irekurwa rya cytokine itera indwara bityo bikagabanya uburibwe bwo munda.

Incamake
Hamwe nogukoresha kubujijwe cyangwa kubuzwa burundu bamwe mubateza imbere antibiyotike nkinyongeramusaruro, hagomba gushakishwa ingamba nshya zo kuzamura no kurengera ubuzima bwinyamanswa.Ubunyangamugayo bwo munda bukora nkimikorere yingenzi hagati yibyo kurya bihenze no kuzamura iterambere muri broilers.Acide Butyric byumwihariko izwi nkizamura imbaraga zubuzima bwa gastrointestinal zimaze gukoreshwa mumyaka irenga 20.Tributyrindelivers aside butyric mu mara mato kandi ifite akamaro kanini mukugira ingaruka ku buzima bwo mu mara byihutisha gahunda yo gusana amara, gushishikariza iterambere ryiza rya villi no guhindura imikorere yubudahangarwa mu mara.

Ubu hamwe na antibiyotike igenda ikurwaho, aside butyric nigikoresho gikomeye cyo gushyigikira inganda kugabanya ingaruka mbi za dysbacteriose igaragara nkimpinduka.