Ihe mgbakwunye nri: Tributyrin

Ọdịnaya: 95%, 90%

Tributyrin dị ka ihe mgbakwunye nri iji weta mmụba na ahụike eriri afọ na anụ ọkụkọ.

Mwepụ nke ọgwụ nje dị ka ndị na-akwalite uto sitere na ntụziaka nri anụ ọkụkọ amụbawo mmasị maka usoro nri nri ọzọ, maka ma ịba ụba nke anụ ọkụkọ yana ichebe megide ọgba aghara pathological.

Na-ebelata ahụ erughị ala dysbacteriosis
Iji nyochaa ọnọdụ dysbacteriosis, a na-agbakwunye ihe mgbakwunye nri dị ka probiotics na prebiotics iji mee ka mmepụta nke SCFA, karịsịa butyric acid nke na-arụ ọrụ dị mkpa n'ichekwa iguzosi ike n'ezi ihe nke eriri afọ.Butyric acid bụ SCFA sitere n'okike nke nwere ọtụtụ uru bara uru dị ka mmetụta mgbochi mkpali ya, mmetụta ya na-eme ka usoro nrụzi eriri afọ dị ngwa ma na-akpali mmepe nke gut villi.Enwere ụzọ pụrụ iche butyric acid si arụ ọrụ site na usoro iji gbochie ọrịa, ya bụ Host Defence Peptides (HDPs) synthesis, nke a makwaara dị ka peptides mgbochi microbial, bụ akụkụ dị oke mkpa nke mgbochi ebumpụta ụwa.Ha nwere ọrụ mgbochi microbial sara mbara nke ukwuu megide nje bacteria, fungi, parasites na nje ndị kpuchiri ekpuchi, bụ nke siri ike maka nje na-eguzogide ọgwụ.Defensins (AvBD9 & AvBD14) na Cathelicidins bụ ezinụlọ abụọ bụ isi nke HDP (Goitsuka et al.; Lynn et al.; Ganz et al.) hụrụ na anụ ọkụkọ nke na-ebuli elu site na mgbakwunye butyric acid.Na nyocha nke Sunkara et.al.nchịkwa oke nke butyric acid na-ebute mmụba dị ịrịba ama na mkpụrụ ndụ ihe nketa HDP ma si otú a na-akwalite ikike iguzogide ọrịa na ọkụkọ.N'ụzọ na-akpali mmasị, agafeghị oke na LCFAs n'akụkụ.

Uru ahụike nke Tributyrin
Tributyrin bụ precursor nke butyric acid nke na-enye ohere ka ebunyekwu mkpụrụ ndụ butyric acid n'ime obere eriri afọ ozugbo n'ihi teknụzụ esterification.N'ihi ya, ntinye uche dị okpukpu abụọ ma ọ bụ atọ dị elu karịa ngwaahịa ndị a kpuchiri ekpuchi.Esterification na-enye ohere ijikọ mkpụrụ ndụ butyric acid atọ na glycerol nke enwere ike imebi ya naanị site na lipase pancreatic endogenous.
Li et.al.guzobe ọmụmụ ihe mgbochi iji chọpụta mmetụta bara uru nke tributyrin na cytokines pro-inflammatory na broilers gbara aka na LPS (lipopolysaccharide).A na-amata ojiji LPS n'ọtụtụ ebe iji kpalite mbufụt na ọmụmụ ihe dị ka nke a ebe ọ na-eme ka akara mkpali dị ka IL (Interleukins).Na ụbọchị 22, 24, na 26 nke ikpe ahụ, a gbara ndị broilers aka na nchịkwa intraperitoneal nke 500 μg / kg BW LPS ma ọ bụ saline.Ihe mgbakwunye nri tributyrin nke 500 mg / kg gbochiri mmụba nke IL-1β & IL-6 na-atụ aro na mgbakwunye ya nwere ike ibelata ntọhapụ nke cytokines pro-inflammatory wee si otú a belata mbufụt nke eriri afọ.

Nchịkọta
Site na mmachi ma ọ bụ mmachibido iwu ụfọdụ na-akwalite uto ọgwụ nje dị ka ihe mgbakwunye nri, a ga-enyocharịrị atụmatụ ọhụrụ maka imeziwanye na ichekwa ahụike anụmanụ ugbo.Iguzosi ike n'ezi ihe nke eriri afọ na-eje ozi dị ka ihe dị mkpa n'etiti ngwa nri dị oke ọnụ na nkwalite uto na broilers.A na-amata acid butyric karịsịa dị ka ihe na-akwalite ahụ ike nke eriri afọ nke ejirila na nri anụmanụ ihe karịrị afọ 20.Tributyrindelivers butyric acid na obere eriri afọ ma na-arụ ọrụ nke ọma na-emetụta ahụ ike eriri afọ site na-eme ka usoro nrụzi eriri afọ dị ngwa, na-agba ume mmepe villi kacha mma na imezi mmeghachi omume mgbochi na eriri afọ.

Ugbu a na ọgwụ nje na-ewepụ, butyric acid bụ ngwá ọrụ dị ukwuu iji kwado ụlọ ọrụ ahụ iji belata mmetụta ọjọọ nke dysbacteriosis nke na-apụta n'ihi mgbanwe a.