Izongezo zokutya: Tributyrin

Umxholo: 95%, 90%

I-Tributyrin njengesongezo sokutya ukuzisa uphuculo kwimpilo yamathumbu kwiinkukhu.

Ukukhutshwa kwamayeza okubulala iintsholongwane njengabakhuthazi bokukhula kwiiresiphi zokutya kweenkukhu kunyuse umdla weendlela ezizezinye zezondlo, kuzo zombini eziyandisa ukusebenza kweenkukhu kunye nokukhusela kuphazamiso lwezifo.

Ukunciphisa ukuphazamiseka kwe-dysbacteriosis
Ukuze ugcine ujongo kwiimeko ze-dysbacteriosis, izongezo zokutya ezifana ne-probiotics kunye ne-prebiotics zongezwa ukuphembelela ukuveliswa kwe-SCFAs, ngokukodwa i-asidi ye-butyric edlala indima ephambili ekukhuseleni ingqibelelo yendlela yamathumbu.I-Butyric acid yi-SCFA eyenzeka ngokwemvelo eneziphumo ezininzi eziluncedo ezinjengokuchasa ukudumba, impembelelo yayo yokukhawulezisa inkqubo yokulungisa amathumbu kunye nokukhuthaza ukukhula kwe-gut villi.Kukho indlela eyodwa i-asidi ye-butyric esebenza ngayo ngendlela yokuthintela usulelo, oko kukuthi i-Host Defense Peptides (HDPs) synthesis, ekwaziwa ngokuba yi-anti-microbial peptides, eziyinxalenye ebalulekileyo yokugonywa kwemvelo.Zinomsebenzi obanzi wokulwa neentsholongwane ezichasene nebhaktiriya, umngundo, izifunxi-gazi kunye neentsholongwane ezigutyungelweyo ekunzima kakhulu ukuba iintsholongwane zikwazi ukumelana nazo.I-Defensins (AvBD9 & AvBD14) kunye neCathelicidins zezona ntsapho zinkulu zeHDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) ezifumaneka kwinkukhu ezifumana ukongezwa nge butyric acid supplementation.Kuphononongo olwenziwe nguSunkara et.al.Ulawulo lwangaphandle lwe-butyric acid lubangela ukwanda okumangalisayo kwimbonakalo yemfuza ye-HDP kwaye oko konyusa amandla okumelana nezifo kwiinkukhu.Okubangela umdla, imodareyitha kunye ne-LCFAs esecaleni.

Izibonelelo zezempilo ze-Tributyrin
I-Tributyrin yi-precursor ye-butyric acid evumela iimolekyuli ezininzi ze-butyric acid ukuba zihanjiswe kumathumbu amancinci ngokuthe ngqo ngenxa ye-esterification technic.Ngaloo ndlela, ugxininiso luphindwe kabini ukuya kathathu phezulu kuneemveliso eziqhelekileyo ezigqunyiweyo.I-Esterification ivumela iimolekyuli ezintathu ze-butyric acid ukuba zibotshelelwe kwi-glycerol enokophulwa kuphela yi-endogenous pancreatic lipase.
Li et.al.misela uphononongo lwe-immunoloji ukufumana iziphumo eziluncedo ze-tributyrin kwi-pro-inflammatory cytokines kwiibroilers ezinomngeni nge-LPS (lipopolysaccharide).Ukusetyenziswa kwe-LPS kwamkelwa ngokubanzi ukukhuthaza ukudumba kwizifundo ezinje kuba ivuselela iimpawu ezivuthayo ezifana ne-IL (Interleukins).Ngeentsuku ze-22, i-24, kunye ne-26 yovavanyo, ii-broilers zacelwa umngeni kunye nokulawulwa kwe-intraperitoneal ye-500 μg / kg ye-BW LPS okanye i-saline.I-Dietary tributyrin supplementation ye-500 mg / kg inqande ukwanda kwe-IL-1β & IL-6 ebonisa ukuba ukuxhaswa kwayo kukwazi ukunciphisa ukukhululwa kwe-cytokines e-pro-inflammatory kwaye ngaloo ndlela ukunciphisa ukuvuvukala kwamathumbu.

Isishwankathelo
Ngokusetyenziswa okuthintelweyo okanye ukuvalwa ngokupheleleyo kwezinye izikhuthazi zokukhula kwamayeza okubulala iintsholongwane njengezongezo zesondlo, iindlela ezintsha zokuphucula nokukhusela impilo yezilwanyana zasefama kufuneka zijongwe.Ukuthembeka kwamathumbu kusebenza njengojongano olubalulekileyo phakathi kwemathiriyeli yesondlo ebiza imali eninzi kunye nokukhuthaza ukukhula kwiinyama zenyama.Iasidi yeButyric ngakumbi ibonwa njengento ekhuthaza impilo yesisu esele isetyenziswa kwisondlo sezilwanyana ngaphezu kweminyaka engama-20.I-Tributyrindelivers i-butyric acid kumathumbu amancinci kwaye iyasebenza kakhulu ekuphembeleleni impilo yamathumbu ngokukhawulezisa inkqubo yokulungisa amathumbu, ukukhuthaza uphuhliso oluphezulu lwe-villi kunye nokulungelelanisa ukusabela komzimba kwi-intestinal tract.

Ngoku kunye ne-antibiotics iyakhutshwa, i-asidi ye-butyric sisixhobo esihle sokuxhasa ishishini ukunciphisa impembelelo engalunganga ye-dysbacteriosis ebonakala ngenxa yolu tshintsho.