Isengezo sokuphakelayo: Tributyrin

Okuqukethwe: 95%, 90%

I-Tributyrin njengesengezo sokuphakelayo ukuletha ngcono empilweni yamathumbu ezinkukhu.

Ukuqedwa kwemithi elwa namagciwane njengabagqugquzeli bokukhula abavela emaresiphi wokuphakelwa kwezinkukhu kukhulise intshisekelo yezinye izindlela zokudla okunomsoco, kokubili okwandisa ukusebenza kwezinkukhu kanye nokuvikela ekuphazamisekeni kokugula.

Ukunciphisa ukungakhululeki kwe-dysbacteriosis
Ukuze uhlole izimo ze-dysbacteriosis, izithasiselo zokudla ezifana nama-probiotics nama-prebiotics ziyengezwa ukuze zibe nomthelela ekukhiqizweni kwama-SCFA, ikakhulukazi i-butyric acid edlala indima ebalulekile ekuvikeleni ubuqotho bepheshana lamathumbu.I-Butyric acid iyi-SCFA eyenzeka ngokwemvelo enemiphumela eminingi enenzuzo eguquguqukayo njengomphumela wayo wokulwa nokuvuvukala, umthelela wayo wokusheshisa inqubo yokulungisa amathumbu futhi ikhuthaze ukukhula kwe-gut villi.Kunendlela ehlukile ye-asidi ye-butyric esebenzisa indlela yokuvimbela ukutheleleka, okuyi-Host Defence Peptides (HDPs) synthesis, eyaziwa nangokuthi ama-peptides anti-microbial, ayizingxenye ezibalulekile zokugonywa kwangaphakathi.Banomphumela obanzi wokulwa namagciwane ngokumelene namagciwane, isikhunta, izimuncagazi kanye namagciwane amboziwe okunzima kakhulu ukuthi amagciwane akwazi ukumelana nawo.I-Defensins (AvBD9 & AvBD14) kanye ne-Cathelicidins imindeni emibili emikhulu yama-HDP (Goitsuka et al.; Lynn et al.; Ganz et al.) atholakala ezinkukhuni ezikhuliswa ukwengezwa kwe-butyric acid.Ocwaningweni olwenziwe nguSunkara et.al.Ukuphathwa kwangaphandle kwe-butyric acid kubangela ukwanda okuphawulekayo kofuzo lwe-HDP futhi ngaleyo ndlela kuthuthukisa amandla okumelana nezifo ezinkukhu.Kuyathakazelisa ukuthi okumaphakathi kanye nama-LCFAs aphansi.

Izinzuzo zezempilo ze-Tributyrin
I-Tributyrin iyisandulela se-butyric acid evumela ama-molecule engeziwe e-butyric acid ukuthi alethwe emathunjini amancane ngokuqondile ngenxa ye-esterification technic.Ngaleyo ndlela, ukugxila kuphakeme ngokuphindwe kabili kuya kathathu kunemikhiqizo evamile eboshwe.I-Esterification ivumela ama-molecule amathathu e-butyric acid ukuthi aboshwe ku-glycerol engaphulwa kuphela yi-endogenous pancreatic lipase.
Li et.al.setha ucwaningo lwe-immunology ukuze uthole imiphumela enenzuzo ye-tributyrin kuma-cytokines abangela ukuvuvukala kuma-broilers anenselelo ye-LPS (lipopolysaccharide).Ukusetshenziswa kwe-LPS kwamukelwa kabanzi ukuze kubangele ukuvuvukala ezifundweni ezinjengalezi njengoba kusebenzisa izimpawu zokuvuvukala ezifana ne-IL (Interleukins).Ezinsukwini ezingama-22, 24, no-26 zecala, ama-broilers aphonselwa inselelo ngokuphathwa kwe-intraperitoneal ye-500 μg/kg BW LPS noma usawoti.I-Dietary tributyrin supplementation ye-500 mg / kg ivimbele ukwanda kwe-IL-1β & IL-6 ephakamisa ukuthi ukwesekwa kwayo kuyakwazi ukunciphisa ukukhululwa kwama-cytokines aphikisana nokuvuvukala futhi ngaleyo ndlela kunciphise ukuvuvukala kwamathumbu.

Isifinyezo
Ngokusetshenziswa okuvinjelwe noma ukuvinjelwa okuphelele kwabagqugquzeli bokukhula kwemithi elwa namagciwane njengezithasiselo zokudla, amasu amasha okuthuthukisa nokuvikela impilo yezilwane zasemapulazini kufanele ahlolwe.Ubuqotho bamathumbu busebenza njengesixhumi esibonakalayo esibalulekile phakathi kwezinto zokusetshenziswa okuphakelayo ezibizayo kanye nokukhuthazwa kokukhula kwezinkukhu.I-Butyric acid ikakhulukazi ibonakala njengesikhuthazi esinamandla sempilo yamathumbu esivele sisetshenziswa ekudleni kwezilwane iminyaka engaphezu kwengu-20.I-Tributyrindelivers i-butyric acid emathunjini amancane futhi iphumelela kakhulu ekuthinteni impilo yamathumbu ngokusheshisa inqubo yokulungisa amathumbu, ikhuthaze ukuthuthukiswa kwe-villi efanele futhi iguqule ukusabela komzimba emgudwini wamathumbu.

Manje njengoba i-antibiotic ikhishwa, i-butyric acid iyithuluzi elihle lokusekela imboni ukunciphisa umthelela omubi we-dysbacteriosis obonakala ngenxa yalolu shintsho.