Chowonjezera cha chakudya: Tributyrin

Chiwerengero: 95%, 90%

Tributyrin monga chowonjezera cha chakudya kuti abweretse thanzi lamatumbo mu nkhuku.

Kuchotsedwa kwa maantibayotiki monga olimbikitsa kukula kuchokera ku maphikidwe a zakudya za nkhuku kwawonjezera chidwi cha njira zina zopezera zakudya, powonjezera mphamvu ya nkhuku komanso kuteteza ku matenda oyambitsidwa ndi matenda.

Kuchepetsa kupweteka kwa dysbacteriosis
Pofuna kuyang'anitsitsa zochitika za dysbacteriosis, zowonjezera zakudya monga ma probiotics ndi prebiotics zikuwonjezedwa kuti zikhudze kupanga ma SCFAs, makamaka butyric acid yomwe imagwira ntchito yaikulu poteteza matumbo a m'mimba.Butyric acid ndi SCFA yochitika mwachilengedwe yomwe ili ndi zopindulitsa zambiri zosunthika monga momwe zimakhudzira kutupa, mphamvu zake kufulumizitsa njira yokonza matumbo ndikulimbikitsa kukula kwamatumbo.Pali njira yapadera yomwe butyric acid amachitira kudzera mu njira yopewera matenda, yomwe ndi kaphatikizidwe ka Host Defense Peptides (HDPs), yomwe imadziwikanso kuti anti-microbial peptides, yomwe ndi zigawo zofunika kwambiri za chitetezo cham'mimba.Amakhala ndi anti-sipekitiramu yayikulu yolimbana ndi mabakiteriya, bowa, tiziromboti ndi ma virus ophimbidwa omwe ndi ovuta kwambiri kuti tizilombo toyambitsa matenda tiyambe kukana.Defensins (AvBD9 & AvBD14) ndi Cathelicidins ndi mabanja awiri akuluakulu a HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) omwe amapezeka mu nkhuku zomwe zimalimbikitsidwa ndi butyric acid supplementation.Mu kafukufuku wopangidwa ndi Sunkara et.al.Kagwiritsidwe kake ka butyric acid kumapangitsa kuti HDP iwonetseke kwambiri ndipo motero kumapangitsa kuti nkhuku zizitha kupirira matenda.Chosangalatsa ndichakuti, ochepera komanso LCFAs ocheperako.

Ubwino wa Tributyrin paumoyo
Tributyrin ndi kalambulabwalo wa butyric acid yomwe imalola mamolekyu ambiri a butyric acid kuti aperekedwe m'matumbo aang'ono mwachindunji chifukwa chaukadaulo wa esterification.Potero, ndende ndi awiri kapena atatu apamwamba kuposa ndi ochiritsira TACHIMATA mankhwala.Esterification imalola mamolekyu atatu a butyric acid kuti amangirire ku glycerol yomwe imatha kusweka ndi endogenous pancreatic lipase.
Li ndi.al.khazikitsani kafukufuku wa immunological kuti apeze phindu la tributyrin pa ma cytokines oyambitsa kutupa mu broilers omwe amatsutsidwa ndi LPS (lipopolysaccharide).Kugwiritsa ntchito kwa LPS kumadziwika kuti kumayambitsa kutupa m'maphunziro ngati awa chifukwa kumayambitsa zolembera zotupa monga IL (Interleukins).Pa masiku 22, 24, ndi 26 a mayesero, a broilers adatsutsidwa ndi intraperitoneal administration ya 500 μg / kg BW LPS kapena saline.Zakudya za tributyrin supplementation za 500 mg / kg zinalepheretsa kuwonjezeka kwa IL-1β & IL-6 kutanthauza kuti kuphatikizika kwake kumatha kuchepetsa kutulutsidwa kwa ma cytokines oyambitsa kutupa ndipo motero kuchepetsa kutupa m'matumbo.

Chidule
Ndi kugwiritsa ntchito moletsedwa kapena kuletsa kwathunthu kwa olimbikitsa kukula kwa maantibayotiki monga zowonjezera zakudya, njira zatsopano zowongolera ndi kuteteza thanzi la ziweto zapafamu ziyenera kufufuzidwa.Kukhulupirika kwa matumbo kumagwira ntchito ngati mawonekedwe ofunikira pakati pa zinthu zodula zopangira chakudya komanso kukulitsa kukula kwa nkhuku.Butyric acid makamaka imadziwika kuti imalimbitsa thanzi la m'mimba yomwe yakhala ikugwiritsidwa ntchito kale pakudya kwa nyama kwazaka zopitilira 20.Tributyrindelivers butyric acid m'matumbo ang'onoang'ono ndipo ndiwothandiza kwambiri pakukhudza thanzi la matumbo mwa kufulumizitsa njira yokonza matumbo, kulimbikitsa kukula bwino kwa villi ndikuwongolera momwe chitetezo cha mthupi chimagwirira ntchito m'matumbo.

Tsopano ndi maantibayotiki akutha, butyric acid ndi chida chachikulu chothandizira makampani kuti achepetse zotsatira zoyipa za dysbacteriosis zomwe zikuwonekera chifukwa cha kusinthaku.