Quudinta wax lagu daro: Tributyrin

Waxa ku jira: 95%, 90%

Tributyrin sida wax lagu daro quudinta si kor loogu qaado caafimaadka mindhicirka ee digaaga.

Joojinta antibiyootiga sida dhiirrigeliyeyaasha koritaanka cuntooyinka digaaga quudinta ayaa kordhisay xiisaha xeeladaha nafaqeynta ee beddelka ah, labadaba kordhinta waxqabadka digaaga iyo sidoo kale ilaalinta khalkhal abuurka.

Yaraynta dysbacteriosis raaxo-darrada
Si loo hubiyo xaaladaha dysbacteriosis, quudinta waxyaabaha lagu daro sida probiotics iyo prebiotics ayaa lagu daraa si ay u saameeyaan wax soo saarka SCFAs, gaar ahaan butyric acid oo kaalin dhexe ka ciyaara ilaalinta sharafta mareenka mindhicirka.Butyric acid waa SCFA si dabiici ah u dhacda oo leh saameyno badan oo faa'iido leh sida saameynteeda ka hortagga bararka, saameynteeda si ay u dedejiso habka dayactirka mindhicirka iyo kicinta korriinka mindhicirka.Waxaa jira hab gaar ah oo loo yaqaan 'butyric acid' iyada oo loo marayo habka looga hortagayo caabuqa, kuwaas oo ah Host Defence Peptides (HDPs), oo sidoo kale loo yaqaanno peptides-ka anti-microbial, kuwaas oo ah qaybaha muhiimka ah ee difaaca gudaha.Waxay leeyihiin firfircooni ballaaran oo ka hortagga microbial-ka bakteeriyada, fangaska, dulinnada iyo fayrasyada daboolan kuwaas oo aad ugu adag in cudur-sidaha si ay u yeeshaan iska caabbinta.Difaacayaasha (AvBD9 & AvBD14) iyo Cathelicidins waa labada qoys ee ugu waaweyn HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) ee laga helo digaagga kaas oo kor u qaadaya kaabista butyric acid.Daraasad uu sameeyay Sunkara et.al.Maamulka ka baxsan ee butyric acid waxay keenaysaa koror cajiib ah oo muujinta hidda-wadaha HDP oo sidaas awgeed waxay kordhisaa awoodda iska caabbinta cudurrada ee digaagga.Waxa xiiso leh, dhexdhexaad ah iyo LCFA-yada yar.

Faa'iidooyinka caafimaad ee Tributyrin
Tributyrin waa horudhac acid butyric kaas oo u oggolaanaya unugyo badan oo butyric acid ah in si toos ah loo geeyo mindhicirka yar sababtoo ah farsamada esterification.Sidaa darteed, fiirsiyada ayaa laba ilaa saddex jeer ka sarreeya alaabooyinka dahaaran ee caadiga ah.Esterification waxay u ogolaataa saddex molecules acid butyric in lagu xidho glycerol kaas oo kaliya lagu jebin karo lipase ganaca leh ee endogenous.
Li iyoal.Samee daraasadda difaaca jirka si loo helo saamaynta faa'iidada leh ee tributyrin ee cytokines pro-inflammatory ee broilers oo loolan kula jiro LPS (lipopolysaccharide).Isticmaalka LPS ayaa si weyn loo aqoonsan yahay inuu keeno barar daraasado sidan oo kale ah maadaama ay kiciso calaamadaha caabuqa sida IL (Interleukins).Maalmaha 22, 24, iyo 26 ee tijaabada, broilers ayaa lagu xujeeyay maamulka intraperitoneal ee 500 μg/kg BW LPS ama cusbada.Kaabista tributyrin-ka ee 500 mg/kg ayaa hakisay kororka IL-1β & IL-6 taasoo soo jeedinaysa in kabitaankeedu uu awoodo inuu yareeyo sii-deynta cytokines-ka-bararka oo sidaas awgeed yareeyo caabuqa mindhicirka.

Soo koobid
Isticmaalka xaddidan ama gebi ahaanba mamnuucida qaar ka mid ah dhiirrigeliyeyaasha koritaanka antibiyootiga sida wax lagu daro quudinta, xeeladaha cusub ee hagaajinta iyo ilaalinta caafimaadka xoolaha waa in la sahamiyaa.Daacadnimada mindhicirku waxay u adeegtaa is dhexgal muhiim ah oo u dhexeeya alaabta ceeriin ee qaaliga ah iyo kor u qaadida korriinka broilers.Aashitada Butyric gaar ahaan waxaa loo aqoonsan yahay inay tahay xoojisay caafimaadka caloosha iyo mindhicirka oo horay loogu isticmaalay quudinta xoolaha in ka badan 20 sano.Tributyrindelivers butyric acid ee xiidmaha yar oo aad wax ku ool u saamayn caafimaadka mindhicirka iyadoo la dedejiyo habka hagaajinta mindhicirka, dhiiri horumarinta villi fiicnayn iyo beddelo falcelinta difaaca ee mareenka mindhicirka.

Hadda antibiyootiga ayaa la sii daayay, butyric acid waa qalab weyn oo lagu taageerayo warshadaha si loo yareeyo saameynta xun ee dysbacteriosis taas oo kor u qaadaysa natiijada isbeddelkan.