Kenyelletso ea lijo: Tributyrin

Litaba: 95%, 90%

Tributyrin e le tlatsetso ea phepelo ho tlisa ntlafatso ea bophelo bo botle ba maleng likhoho.

Ho tlosoa ha lithibela-mafu joalo ka bahlohlelletsi ba kholo ho tsoa ho diresepe tsa phepo ea likhoho ho ekelitse thahasello ea mekhoa e meng ea phepo e nepahetseng, bakeng sa ts'ebetso e ntseng e eketseha ea likhoho hammoho le ho sireletsa khahlanong le tšitiso ea mafu.

Ho fokotsa bohloko ba dysbacteriosis
E le ho boloka tlhahlobo ea maemo a dysbacteriosis, li-additives tsa phepelo tse kang li-probiotics le li-prebiotics li ntse li eketsoa ho susumetsa tlhahiso ea SCFAs, haholo-holo butyric acid e bapalang karolo ea bohlokoa ho sireletsang botšepehi ba mala.Butyric acid ke SCFA ea tlhaho e nang le litlamorao tse ngata tse fapaneng joalo ka phello ea eona e khahlanong le ho ruruha, tšusumetso ea eona ho potlakisa ts'ebetso ea ho lokisa mala le ho susumetsa nts'etsopele ea mala.Ho na le tsela e ikhethang ea butyric acid e sebetsang ka mokhoa oa ho thibela ts'oaetso, e leng Host Defense Peptides (HDPs) synthesis, e tsejoang hape e le anti-microbial peptides, tseo e leng likarolo tsa bohlokoa tsa ts'ireletso ea tlhaho.Li na le ts'ebetso ea anti-microbial e pharaletseng khahlano le libaktheria, li-fungus, likokoana-hloko le livaerase tse apesitsoeng tseo ho leng thata haholo hore likokoana-hloko li ka itoanela.Defensins (AvBD9 & AvBD14) le Cathelicidins ke malapa a mabeli a maholo a HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) a fumanoang likhoho tse matlafatsoang ke butyric acid supplementation.Phuputsong e entsoeng ke Sunkara et.al.Tsamaiso e sa tloaelehang ea asiti ea butyric e etsa hore ho be le keketseho e makatsang ea liphatsa tsa lefutso tsa HDP 'me kahoo e matlafatsa matla a ho hanyetsa maloetse likhohong.Hoa thahasellisa hore e itekanetse le LCFAs marginal.

Melemo ea bophelo bo botle ea Tributyrin
Tributyrin ke selelekela sa asiti ea butyric e lumellang limolek'hule tse ngata tsa butyric acid hore li kenngoe ka maleng a manyane ka kotloloho ka lebaka la tekheniki ea esterification.Ka hona, likhakanyo li phahame ka makhetlo a mabeli ho isa ho a mararo ho feta lihlahisoa tse tloaelehileng tse koahetsoeng.Esterification e lumella limolek'hule tse tharo tsa butyric acid hore li tlameletsoe ho glycerol e ka robehang feela ke pancreatic lipase.
Li et.al.theha boithuto ba ho itšireletsa mafung ho fumana litlamorao tse molemo tsa tributyrin ho li-cytokine tse pro-inflammatory ho likhoho tsa nama tse qholotsoeng ke LPS (lipopolysaccharide).Tšebeliso ea LPS e tsebahala haholo ho baka ho ruruha lithutong tse kang tsena kaha e kenya matšoao a ho ruruha joalo ka IL (Interleukins).Ka matsatsi a 22, 24, le a 26 a teko, likhoho tsa nama li ile tsa phephetsoa ka tsamaiso ea intraperitoneal ea 500 μg/kg BW LPS kapa saline.Tlatsetso ea lijo tsa tributyrin ea 500 mg / kg e thibela ho eketseha ha IL-1β & IL-6 e fanang ka maikutlo a hore tlatsetso ea eona e khona ho fokotsa ho lokolloa ha li-cytokine tse nang le pro-inflammatory mme kahoo ho fokotsa ho ruruha ha mala.

Kakaretso
Ka tšebeliso e thibetsoeng kapa thibelo e felletseng ea li-protectors tse itseng tsa kholo ea lithibela-mafu e le li-additives tsa phepelo, maano a macha a ho ntlafatsa le ho sireletsa bophelo ba liphoofolo tsa polasing a tlameha ho hlahlojoa.Botšepehi ba mala bo sebetsa e le sehokelo sa bohlokoa lipakeng tsa thepa e tala ea phepelo e turang le kholiso ea kholo ea likhoho tsa nama.Butyric acid ka ho khetheha e amoheloa e le se matlafatsang bophelo bo botle ba mala se seng se ntse se sebelisoa lijong tsa liphoofolo ka lilemo tse fetang 20.Tributyrindelivers butyric acid ka maleng a manyane mme e sebetsa haholo ho amang bophelo bo botle ba mala ka ho potlakisa ts'ebetso ea ho lokisa mala, e khothaletsa nts'etsopele e nepahetseng ea villi le ho fetola tšebetso ea 'mele ea ho itšireletsa mafung ka har'a pampiri ea mala.

Hona joale ka lithibela-mafu li ntse li tlosoa, butyric acid ke sesebelisoa se seholo sa ho tšehetsa indasteri ho fokotsa tšusumetso e mpe ea dysbacteriosis e hlahang ka lebaka la phetoho ena.