Kuwedzera kwekudya: Tributyrin

Zviri mukati: 95%, 90%

Tributyrin sekuwedzera kwekudya kuunza kuvandudzwa kwehutano hwehuku muhuku.

Kubvisa kunze kwemishonga inorwisa mabhakitiriya sevanosimudzira kukura kubva mukudya kwehuku mabikirwo kwakawedzera kufarira kune dzimwe nzira dzekudya kunovaka muviri, kune zvese zviri kuwedzera kuita kwehuku pamwe nekudzivirira kubva pakukanganiswa kwezvirwere.

Kuderedza kusagadzikana kwedysbacteriosis
Kuti uchengete cheki pane dysbacteriosis mamiriro, ekuwedzera ezvekudya akadai seprobiotics uye prebiotics ari kuwedzerwa kukurudzira kugadzirwa kweSCFAs, kunyanya butyric acid inoita basa repakati mukudzivirira kutendeka kwemukati.Butyric acid ndeye SCFA inongoitika ine zvakawanda zvakasiyana-siyana zvinobatsira senge anti-kuzvimba mhedzisiro, simba rayo kukurumidza kugadzirisa intestinal uye inosimudzira gut villi kukura.Pane yakasarudzika nzira butyric asidhi inoshanda kuburikidza nenzira yekudzivirira kutapukirwa, inoti Host Defense Peptides (HDPs) synthesis, inozivikanwawo seanti-microbial peptides, izvo zvakakosha zvikamu zvemukati mekudzivirira.Ivo vane wide-spectrum anti-microbial chiitiko kurwisa mabhakitiriya, fungi, tupukanana uye mavhairasi akaputirwa izvo zvakanyanya kuomera hutachiona kusimudzira kurwisa.Defensins (AvBD9 & AvBD14) neCathelicidins ndidzo mhuri mbiri huru dzeHDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) inowanikwa muhuku inowedzerwa nebutyric acid supplementation.Muchidzidzo chakaitwa naSunkara et.al.exogenous administration yebutyric acid inokonzeresa kuwedzera kunoshamisa kweHDP gene expression nekudaro inowedzera kugona kurwisa zvirwere muhuku.Zvinofadza, zvine mwero uye LCFAs marginal.

Utano hunobatsira hweTributyrin
Tributyrin inotangira butyric acid inobvumira mamwe mamorekuru e butyric acid kuti apinzwe mudumbu diki zvakananga nekuda kweiyo esterification technic.Nekudaro, iwo maconcentrations akapetwa kaviri kana katatu kupfuura neyakajairwa yakavharwa zvigadzirwa.Esterification inobvumira matatu butyric acid mamorekuru kuti asungirwe kune glycerol iyo inogona chete kutyorwa ne endogenous pancreatic lipase.
Li et.al.kumisikidza chidzidzo cheimmunological kuti uwane zvinobatsira zve tributyrin pane pro-inflammatory cytokines mumabroilers akapikiswa neLPS (lipopolysaccharide).Kushandiswa kweLPS kunozivikanwa zvakanyanya kukonzera kuzvimba muzvidzidzo zvakaita seizvi sezvo ichimisikidza zviratidzo zvekuzvimba zvakaita seIL (Interleukins).Pamazuva 22, 24, uye 26 ekutongwa, broilers vakapikiswa ne intraperitoneal administration ye500 μg/kg BW LPS kana saline.Dietary tributyrin supplementation ye500 mg / kg yakadzivisa kuwedzera kweIL-1β & IL-6 ichiratidza kuti kuwedzera kwayo kunokwanisa kuderedza kusunungurwa kwepro-inflammatory cytokines uye nokudaro kuderedza kuputika kwematumbo.

Summary
Nekurambidzwa kushandiswa kana kurambidzwa kwakazara kune mamwe maantibioti anokurudzira kukura sezvinowedzera zvekudya, nzira nyowani dzekuvandudza nekuchengetedza hutano hwemhuka dzepurazi dzinofanirwa kuongororwa.Kuvimbika kwematumbo kunoshanda seyakakosha interface pakati pezvinodhura zvekudya mbishi zvinhu uye kukurudzira kukura mumabroilers.Butyric acid kunyanya inozivikanwa sechinhu chinowedzera simba chehutano hwemudumbu icho chakatoshandiswa mukudya kwemhuka kweanopfuura makore makumi maviri.Tributyrindelivers butyric acid mudumbu diki uye inoshanda zvakanyanya mukukanganisa hutano hwematumbo nekumhanyisa maitiro ekugadzirisa intestinal, ichikurudzira kukwidziridzwa kweVilli uye kugadzirisa maitiro ezvirwere mudumbu remukati.

Iye zvino nemishonga inorwisa mabhakitiriya iri kubviswa, butyric acid chinhu chikuru chekutsigira indasitiri kuderedza kuipa kwe dysbacteriosis iyo iri kutarisana nekuda kwekuchinja uku.