I-Betaineisakhi esisebenzayo esivame ukusetshenziswa njengesengezo sokudla ekudleni kwezilwane, ikakhulukazi njenge-methyl donor.Iyiphi indima engadlalwa i-betaine ekudleni kwezinkukhu ezizalelayo futhi yimiphi imiphumela?

e igcwaliseke ekudleni okuvela izithako ezingavuthiwe.I-Betaine inganikela ngokuqondile elinye lamaqembu ayo e-methyl kumjikelezo we-methylation, kanti i-choline idinga ukuguqulwa kwe-enzymatic okuzinyathelo ezimbili ku-mitochondria ngaphakathi kwamaseli esibindi.Ngakho-ke, i-betaine izosebenza kahle njenge-methyl donor uma iqhathaniswa ne-choline.Ama-molecule e-betaine engeziwe ayakwazi ukungena ngaphakathi kwamaseli ukuze agcine ubuqotho beseli (amathumbu), ukwakheka kwamaprotheni, kanye ne-homeostasis.Ukugcina ubuqotho bamangqamuzana amathumbu kanye nempilo yamathumbu kuyisisekelo sokuthuthukisa ukuphila, ukugayeka kokudla okunomsoco kanye nokukhiqizwa.

Isivivinyo sezentengiso

Ukufakazela imiphumela enenzuzo ye-betaine uma iqhathaniswa ne-choline, ucwaningo lwendlu ebhangqiwe yase-US lwenziwa phakathi nenkathi yokukhiqiza yongqimba.Emavikini angu-21 ubudala, izingqimba ze-Lohman ezinsundu ohlelweni olungenalo ikheji zanikezwa ukudla okulawulayo okuhlanganisa u-500 ppm we-choline chloride engu-60% noma ukudla okuthatha indawo yale choline ngo-348 ppm we-Excential Beta-Key (betaine hydrochloride 95%). .Ku-348 ppm, i-ExcentialI-Beta-Keyithatha indawo yokulingana kwe-100% ye-equimolar ye-500 ppm 60% ye-choline chloride, okusho ukuthi kokubili ukulawula nokudla kokuhlola kuhlinzekele inani elifanayo lamangqamuzana abanikeli be-methyl, njenge-choline noma i-betaine, ngokulandelana.

Idatha yokukhiqiza ibonise ukuthi emasontweni angama-59 ubudala noma, amasonto angu-38 kusukela ekuqaleni kocwaningo isilinganiso samaqanda esikhukhukazi ngasinye esifuywe sibe ngcono ngamaqanda angu-3.4.Ngokombono wokukhiqiza, kwakhiqizwa amanye amaqanda angama-60,396 njengoba kubonakala kuUmfanekiso 1.

Umfanekiso 1 - Ukukhiqizwa kwamaqanda Okunqwabelanayo kusuka emasontweni angama-21-59 ubudala.

Ngaphandle koshintsho lokuphatha ngaphandle kokwengeza i-betaine, emakethe yase-US ukungezwa kwe-Excential Beta-Key ku-348 ppm nokuthatha indawo ye-choline chloride eyengeziwe kubalwe ukuze kuphumele ku-ROI okungenani engu-6:1 ekukhiqizweni kwezinyoni ezingu-20,000.

Ithonya kumswakama kadoti nokufa
Enye ipharamitha ebalulekile ekuphathweni kwezinkukhu umswakama kadoti.Ukugayeka kokudla okuthuthukisiwe nokukhula kwamangqamuzana amathumbu kuye kwahlotshaniswa ne-betaine eyengeziwe.Lezi zici zibangelwa ukugcinwa kwamanzi okuthuthukisiwe kwesilwane kanjalo nokulawula indle.

Ukunyuka komswakama kadoti kwehlisa ikhwalithi kadoti futhi kungaholela ezinkingeni zokukhiqiza okuhlanganisa kodwa kungagcini nje ngokukhuphuka amazinga e-ammonia, izinkinga ezikhulayo ngekhwalithi ye-footpad namaqanda angcolile.Ukuthuthukisa ukugayeka kokudla okunomsoco ngokufaka i-betaine nakho kungathinta umswakama kadoti.Ngesikhathi sokuhlolwa kwezentengiso, amasampula kadoti kuzona zombili izindlu aqoqwa emasontweni angama-35, 45 kanye nama-55.Nakuba njengoba kubonakala kuThebula 1, umswakama kadoti ubuphethwe kahle, okwengeza i-betaine hydrochloride enciphise kakhulu umswakama ngaphezu kuka-3%.Ukusebenzisa i-betaine hydrochloride esikhundleni se-choline chloride, ikakhulukazi ezindlini ezidinga ukulawula umswakama kungase kube ithuluzi eliwusizo kubakhiqizi.

Ukufa nokuphila nakho kuyizici ezibalulekile emhlambini ophumelelayo.Njengoba kubonakala kuThebula 2, i-betaine yehlisa ukufa komhlambi kufika ku-1.98%.

I-Betaine iyithuluzi eliwusizo labakhiqizi

I-Excential Beta-Key ingangena esikhundleni sika-100% we-choline chloride engeziwe ngezandlalelo.Ngenxa yokuthi ukusebenza kahle kwe-betaine njenge-methyldonor kuphezulu uma kuqhathaniswa ne-choline, insalela ye-betaine etholakalayo izendlalelo ithuthukisa ukusebenza kahle kwamaselula futhi isiza ukuthuthukisa ukusebenza.Ngokunciphisa ukufa kanye nomswakama kadoti, i-betaine iyithuluzi eliwusizo labakhiqizi lokuthuthukisa impilo yonke yengqimba.Ngokwandisa ukusebenza kahle kwe-osmoregulation, insalela ye-betaine ingase inciphise ukuwohloka kwamaprotheni eqandeni, ngakho-ke i-betaine ithuthukisa ikhwalithi yeqanda futhi andise ubusha.