ʻO ka sodium Butyrate a i ʻole tributyrin'ʻo wai ka mea e koho ai'?

Ua ʻike maʻamau ʻo ka waikawa butyric kahi kumu nui o ka ikehu no nā cell colonic.Eia kekahi, ʻo ia ke kumu wahie makemake nui a hāʻawi i ka 70% o kā lākou mau pono ikehu.Eia naʻe, aia nā ʻano 2 e koho ai.Hāʻawi kēia ʻatikala i kahi hoʻohālikelike o nā mea ʻelua, e kōkua ana e pane i ka nīnau 'ʻo wai ka mea e koho ai'?

Ua aʻo nui ʻia ka hoʻohana ʻana i ka butyrates ma ke ʻano he meaʻai meaʻai a hoʻohana ʻia i ka mahiʻai holoholona no nā makahiki he nui, ua hoʻohana mua ʻia i nā keiki bipi e hoʻoulu i ka ulu ʻana o ka rumen ma mua o ka loaʻa ʻana o ka hoʻohana ʻana i ka puaʻa a me ka moa.

Ua hōʻike ʻo Butyrate additives i ka hoʻomaikaʻi ʻana i ke kaumaha o ke kino (BWG) a me nā helu hoʻololi hānai (FCR), e hoʻemi i ka make a hoʻemi i ka hopena o nā maʻi pili i ka ʻōpū.

Loaʻa nā kumu maʻamau o ka butyric acid no ka hānai holoholona ma 2 mau ʻano:

1. E like me ka paʻakai (ie Sodium butyrate) a i ʻole
2. Ma ke ʻano o kahi triglyceride (ie Tributyrin).

A laila hiki mai ka nīnau aʻe -ʻO wai kaʻu e koho ai?Hāʻawi kēia ʻatikala i kahi hoʻohālikelike ʻaoʻao o nā mea ʻelua.

Kaʻina hana hana

ʻO ka sodium butyrate:Hana ʻia ma o ka hopena acid-base e hana i ka paʻakai me kahi helu heheʻe kiʻekiʻe.

NaOH+C4 H8 O2=C4 H7 COONa+H2O

(Sodium Hydroxide+Butyric Acid = Sodium Butyrate+Wai)

Tributyrin:Hana ʻia ma o ka esterification kahi i hoʻopili ʻia ai ka 3 butyric acid i kahi glycerol e hana i ka tributyrin.He haʻahaʻa ko Tributyrin.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(Glycerol+Butyric Acid = Tributyrin + Wai)

ʻO wai ka mea hāʻawi i ka ʻakika butyric hou aʻe no ka huahana?

MaiPapa 1, ʻike mākou i ka nui o ka waikawa butyric i loko o nā huahana like ʻole.Eia nō naʻe, pono mākou e noʻonoʻo pehea e hoʻokuʻu ai kēia mau huahana i ka waikawa butyric i loko o ka ʻōpū.No ka mea he paʻakai ka sodium butyrate, e hemo koke ia i ka butyrate hoʻokuʻu wai, no laila hiki iā mākou ke manaʻo e hoʻokuʻu ʻia ka 100% o ka butyrate mai ka sodium butyrate ke hoʻoheheʻe ʻia.I ka wehe 'ana o ka sodium butyrate, e kōkua ana nā puka i pale 'ia ('o ia ho'i ka micro-encapsulation) o ka sodium butyrate i ka ho'oku'u mau 'ana i ka butyrate ma loko o ka 'ōpū a hiki i ke kolon.

ʻO Tributyrin kahi triacylglyceride (TAG), he ester i loaʻa mai ka glycerol a me 3 mau momona momona.Pono ʻo Tributyrin i ka lipase e hoʻokuʻu i ka butyrate i hoʻopili ʻia i ka glycerol.ʻOiai ʻo 1 tributyrin he 3 butyrate, ʻaʻole pono nā 3 butyrate a pau e hoʻokuʻu ʻia.ʻO kēia no ka mea he regioselective ka lipase.Hiki iā ia ke hoʻoheheʻe i nā triacylglycerides ma R1 a me R3, R2 wale nō, a i ʻole.Loaʻa i ka Lipase kahi kikoʻī substrate i hiki ai i ka enzyme ke hoʻokaʻawale i waena o nā kaulahao acyl i hoʻopili ʻia i ka glycerol a makemake e hoʻokaʻawale i kekahi mau ʻano.No ka mea e koi ana ka tributyrin i ka lipase e hoʻokuʻu i kāna butyrate, aia paha ka hoʻokūkū ma waena o ka tributyrin a me nā TAG ʻē aʻe no ka lipase.

E hoʻopilikia anei ka sodium butyrate a me ka tributyrin i ka ʻai?

He ʻala ʻino ka sodium butyrate a ʻaʻole ʻoluʻolu i ke kanaka akā makemake nui ʻia e nā mammals.ʻO ka sodium butyrate ka 3.6-3.8% o ka momona o ka waiū i ka waiū umauma, no laila, hiki ke hana ma ke ʻano he mea hoʻokipa hānai e hoʻoulu ai i ke ʻano o ke ola ʻana o nā mammals.Papa 2).Eia nō naʻe, no ka hoʻokuʻu lohi ʻana i loko o ka ʻōpū, hoʻopili pinepine ʻia ka sodium butyrate me kahi uhi momona momona (ʻo ia hoʻi ʻo Palm stearin).Kōkua pū kēia i ka hōʻemi ʻana i ka ʻala rancid o ka sodium butyrate.

ʻO Tributyrin ma ka ʻaoʻao ʻē aʻe ʻaʻohe mea ʻala akā he ʻono astringent (Papa 2).Hiki i ka hoʻohui ʻana i nā mea nui ke loaʻa nā hopena maikaʻi ʻole i ka ʻai ʻana i nā meaʻai.ʻO Tributyrin kahi mole paʻa maoli i hiki ke hele ma ka ʻōpū o ka ʻōpū o luna a hiki i ka wā e ʻoki ʻia ai e ka lipase i loko o ka ʻōpū.ʻAʻole hiki ke hoʻololi i ka lumi wela, no laila ʻaʻole i uhi ʻia.Hoʻohana pinepine ʻo Tributyrin i ka silica dioxide inert ma ke ʻano he mea lawe.He porous ka silica dioxide a ʻaʻole hiki ke hoʻokuʻu piha i ka tributyrin i ka wā ʻai.He kiʻekiʻe aʻe ka puʻupuʻu mahu i ka Tributyrin e hoʻoheheʻe ʻia ke wela.No laila, paipai mākou i ka tributyrin e hoʻohana ʻia ma kahi ʻano emulsified a i ʻole ma kahi ʻano pale.