Sodium Butyrate kapena tributyrin'tisankhe uti'?

Nthawi zambiri amadziwika kuti butyric acid ndi gwero lofunikira la mphamvu zama cell a colonic.Kuphatikiza apo, ndiye gwero lamafuta omwe amawakonda kwambiri ndipo amapereka mpaka 70% ya mphamvu zawo zonse.Komabe, pali 2 mafomu oti musankhe.Nkhaniyi ikuyerekeza zonse ziwiri, kutithandiza kuyankha funso lakuti 'ndiye tisankhe iti'?

Kugwiritsiridwa ntchito kwa butyrate monga chowonjezera cha chakudya kwawerengedwa mozama ndikugwiritsidwa ntchito pa ulimi wa zinyama kwa zaka makumi angapo, kumagwiritsidwa ntchito koyamba mu ng'ombe kulimbikitsa chitukuko choyambirira cha rumen musanapeze ntchito mu nkhumba ndi nkhuku.

Zowonjezera za Butyrate zawonetsa kupititsa patsogolo kulemera kwa thupi (BWG) ndi kutembenuka kwa chakudya (FCR), kuchepetsa imfa ndi kuchepetsa zotsatira za matenda okhudzana ndi m'matumbo.

Magwero a butyric acid omwe amapezeka kawirikawiri pazakudya za ziweto amapezeka m'mitundu iwiri:

1. Monga mchere (ie Sodium butyrate) kapena
2. Mu mawonekedwe a triglyceride (ie Tributyrin).

Kenako pamabwera funso lotsatira -Ndisankhe iti?Nkhaniyi ikupereka kufananitsa mbali zonse ziwiri.

Njira yopanga

Sodium butyrate:Amapangidwa ndi acid-base reaction kuti apange mchere wokhala ndi malo osungunuka kwambiri.

NaOH+C4 H8 O2=C4 H7 COONA+H2O

(Sodium Hydrooxide+Butyric Acid = Sodium Butyrate+Madzi)

Tributyrin:Amapangidwa kudzera mu esterification pomwe 3 butyric acid imalumikizidwa ndi glycerol kupanga tributyrin.Tributyrin ili ndi malo osungunuka otsika.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(Glycerol+Butyric Acid = Tributyrin + Madzi)

Ndi iti yomwe imapereka asidi wa butyric pa kilogalamu iliyonse?

KuchokeraTable 1, tikudziwa kuchuluka kwa butyric acid yomwe ili muzinthu zosiyanasiyana.Komabe, tiyeneranso kuganizira momwe mankhwalawa amatulutsira butyric acid m'matumbo.Popeza sodium butyrate ndi mchere, imasungunuka mosavuta m'madzi otulutsa butyrate, choncho tikhoza kuganiza kuti 100% ya butyrate kuchokera ku sodium butyrate idzatulutsidwa ikasungunuka.Pamene sodium butyrate imasiyanitsidwa mosavuta, mitundu yotetezedwa (ie micro-encapsulation) ya sodium butyrate imathandizira kutulutsa pang'onopang'ono kwa butyrate m'matumbo mpaka m'matumbo.

Tributyrin kwenikweni ndi triacylglyceride (TAG), yomwe ndi ester yochokera ku glycerol ndi 3 fatty acids.Tributyrin imafuna lipase kuti itulutse butyrate yomwe imalumikizidwa ndi glycerol.Ngakhale 1 tributyrin ili ndi 3 butyrate, si onse 3 butyrate omwe ali otsimikizika kuti atulutsidwa.Izi ndichifukwa choti lipase ndi regioselective.Imatha hydrolyse triacylglycerides pa R1 ndi R3, R2 yokha, kapena osati mwachindunji.Lipase imakhalanso ndi gawo laling'ono chifukwa enzyme imatha kusiyanitsa pakati pa maunyolo a acyl omwe amamangiriridwa ku glycerol ndikudula mitundu ina.Popeza tributyrin imafuna lipase kuti itulutse butyrate, pakhoza kukhala mpikisano pakati pa tributyrin ndi ma TAG ena a lipase.

Kodi sodium butyrate ndi tributyrin zingakhudze kudya?

Sodium butyrate ili ndi fungo loyipa lomwe silimasangalatsa anthu koma limakondedwa ndi nyama zoyamwitsa.Sodium butyrate imakhala ndi 3.6-3.8% yamafuta amkaka mu mkaka wa m'mawere, motero, imatha kukhala ngati chokopa choyambitsa kupulumuka kwachilengedwe kwa nyama zoyamwitsa.Table 2).Komabe, pofuna kuonetsetsa kuti matumbo atuluka pang'onopang'ono, sodium butyrate nthawi zambiri imakutidwa ndi zokutira zamafuta (mwachitsanzo Palm stearin).Izi zimathandizanso kuchepetsa fungo la sodium butyrate.

Komano Tributyrin ilibe fungo koma ili ndi kukoma kowawa.Table 2).Kuonjezera ndalama zambiri kungakhale ndi zotsatira zoipa pa kudya chakudya.Tributyrin ndi molekyulu yokhazikika yomwe imatha kudutsa m'matumbo am'mimba mpaka itang'ambika ndi lipase m'matumbo.Imakhalanso yosasunthika pa kutentha kwa chipinda, choncho nthawi zambiri imakhala yosakutidwa.Tributyrin nthawi zambiri amagwiritsa ntchito inert silica dioxide monga chonyamulira chake.Silica dioxide ndi porous ndipo sangatulutse kwathunthu tributyrin panthawi ya chimbudzi.Tributyrin imakhalanso ndi mphamvu yowonjezereka ya nthunzi yomwe imapangitsa kuti ikhale yosasunthika ikatenthedwa.Chifukwa chake, timalimbikitsa tributyrin kuti igwiritsidwe ntchito mu mawonekedwe opangidwa ndi emulsified kapena mawonekedwe otetezedwa.