I-Sodium Butyrate okanye i-tributyrin'eyiphi emayikhethe'?

Ngokuqhelekileyo kwaziwa ukuba i-asidi ye-butyric ngumthombo obalulekileyo wamandla kwiiseli ze-colonic.Ngaphaya koko, ngowona mthombo wamafutha okhethwayo kwaye ubonelela ukuya kuthi ga kwi-70% yezidingo zabo zamandla zizonke.Nangona kunjalo, kukho iifom ezi-2 onokukhetha kuzo.Eli nqaku linika uthelekiso lwezo zombini, lunceda ekuphenduleni umbuzo othi 'ukhetho loluphi'?

Ukusetyenziswa kweebutyrates njengesongezo sokutya kuye kwaphononongwa kakhulu kwaye kwasetyenziswa kulimo lwezilwanyana amashumi eminyaka, ziqala ukusetyenziswa kumathole ukuvuselela uphuhliso lwerumen kwangethuba phambi kokuba zifumane ukusetyenziswa kwiihagu kunye neenkukhu.

Izongezo zeButyrate zibonise ukuphucula ubunzima bomzimba (BWG) kunye namazinga okuguqula ukutya (FCR), ukunciphisa ukufa kunye nokunciphisa impembelelo yezifo ezinxulumene namathumbu.

Imithombo exhaphakileyo ye butyric acid ekutyeni kwezilwanyana iza ngeendlela ezimbini:

1. Njengetyuwa (okt sodium butyrate) okanye
2. Ngendlela ye-triglyceride (oko kukuthi i-Tributyrin).

Emva koko kuza umbuzo olandelayo-Ndikhetha eyiphi?Eli nqaku linika uthelekiso olusecaleni kuzo zombini.

Inkqubo yokuvelisa

Isodium butyrate:Iveliswe nge-acid-base reaction ukwenza ityuwa enendawo yokunyibilika ephezulu.

NaOH+C4 H8 O2=C4 H7 COONA+H2O

(I-Sodium Hydroxide+Butyric Acid = I-Sodium Butyrate+Amanzi)

Tributyrin:Iveliswe nge-esterification apho i-3 butyric acid idityaniswe kwi-glycerol ukwenza i-tributyrin.I-Tributyrin inendawo yokunyibilika ephantsi.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(IGlycerol+Butyric Acid = Tributyrin + Amanzi)

Yeyiphi ebonelela ngeasidi ye-butyric ngaphezulu ngekhilogram nganye?

UkusukaUluhlu loku-1, Siyazi inani le-asidi ye-butyric equlethwe kwiimveliso ezahlukeneyo.Nangona kunjalo, kufuneka siqwalasele indlela ezi mveliso zikhulula ngayo i-asidi ye-butyric emathunjini.Ekubeni i-sodium butyrate ityuwa, iya kuchithwa ngokukhawuleza emanzini akhulula i-butyrate, ngoko sinokucinga ukuba i-100% ye-butyrate evela kwi-sodium butyrate iya kukhutshwa xa ichithekile.Njengoko i-sodium butyrate ihlukana ngokukhawuleza, iifom ezikhuselweyo (oko kukuthi i-micro-encapsulation) ye-sodium butyrate iya kunceda ukuphumeza ukukhululwa okucothayo okuqhubekayo kwe-butyrate kuwo wonke amathumbu ukuya kwikholoni.

I-Tributyrin ngokuqhelekileyo i-triacylglyceride (TAG), eyi-ester evela kwi-glycerol kunye ne-3 fatty acids.I-Tributyrin idinga i-lipase ukukhulula i-butyrate efakwe kwi-glycerol.Nangona i-1 tributyrin iqulethe i-3 butyrate, ayizizo zonke i-butyrate ezi-3 eziqinisekisiweyo ukuba zikhutshwe.Oku kungenxa yokuba i-lipase i-regioselective.Inokwenza i-hydrolyse i-triacylglycerides kwi-R1 kunye ne-R3, kuphela i-R2, okanye ingeyiyo ngqo.I-Lipase nayo ine-substrate ethile ecacileyo yokuba i-enzyme inokwahlula phakathi kwamaketanga e-acyl aqhotyoshelwe kwi-glycerol kwaye ngokukhethekileyo ukuqhawula iintlobo ezithile.Ekubeni i-tributyrin idinga i-lipase ukukhulula i-butyrate yayo, kunokubakho ukhuphiswano phakathi kwe-tributyrin kunye nezinye ii-TAG ze-lipase.

Ngaba i-sodium butyrate kunye ne-tributyrin iya kuchaphazela ukutya kokutya?

Isodium butyrate inevumba elikhubekisayo elingamnandanga kangako ebantwini kodwa lithandwa zizilwanyana ezanyisayo.I-sodium butyrate ibalelwa kwi-3.6-3.8% yamanqatha obisi kubisi lwebele, ke ngoko, inokusebenza njengomtsalane wokutya okubangela ithuku lemvelo lokusinda kwezilwanyana ezanyisayo (Itheyibhile 2).Nangona kunjalo, ukuqinisekisa ukukhululwa okucothayo emathunjini, i-sodium butyrate idla ngokugqunywa nge-fat matrix coating (okt iPalm stearin).Oku kukwanceda ekunciphiseni ivumba le-sodium butyrate.

I-Tributyrin kwelinye icala ayinavumba kodwa inencasa ebuhlungu (Itheyibhile 2).Ukongeza izixa ezikhulu kunokuba neziphumo ezibi kwisondlo sokutya.I-Tributyrin yimolekyuli ezinzile ngokwemvelo enokuthi idlule kwindlela ephezulu yesisu ide icolwe yi-lipase emathunjini.Kananjalo ayiguquguquki kwiqondo lobushushu begumbi, ngoko ke ayigqunywanga.I-Tributyrin idla ngokusebenzisa i-silica diokside engasebenziyo njengomphathi wayo.I-silica diokside inamarhashalala kwaye ayinakukhulula ngokupheleleyo i-tributyrin ngexesha lokwetyisa.I-Tributyrin ikwanoxinzelelo oluphezulu lomphunga olubangela ukuba uguquguquke xa ushushu.Ngoko ke, sincoma i-tributyrin ukuba isetyenziswe mhlawumbi kwifom ye-emulsified okanye kwifom ekhuselweyo.