I-Sodium Butyrate noma i-tributyrin'iyiphi ongakhetha'?

Kuyaziwa ukuthi i-butyric acid iwumthombo obalulekile wamandla kumaseli e-colon.Ngaphezu kwalokho, iwumthombo wamafutha othandwayo futhi inikeza kufika ku-70% wengqikithi yezidingo zabo zamandla.Nokho, kunamafomu ama-2 ongakhetha kuwo.Lesi sihloko sinikeza ukuqhathanisa kokubili, kusiza ukuphendula umbuzo othi 'imuphi ongakhetha'?

Ukusetshenziswa kwama-butyrates njengesengezo sokudla kuye kwacutshungulwa kabanzi futhi kwasetshenziswa kwezolimo zezilwane amashumi eminyaka ambalwa, eqala ukusetshenziswa kumathole ukuze kugqugquzelwe ukuthuthukiswa kwe-rumen ngaphambi kokuthola ukusetshenziswa ezingulubeni nasezinkukhuni.

Izithasiselo ze-Butyrate zibonise ukuthuthukisa ukuzuza kwesisindo somzimba (BWG) kanye namazinga okuguqulwa kokudla (FCR), ukunciphisa ukufa kanye nokunciphisa umthelela wezifo ezihlobene namathumbu.

Imithombo evame ukutholakala ye-butyric acid yokudla kwezilwane iza ngezindlela ezi-2:

1. Njengosawoti (okungukuthi i-sodium butyrate) noma
2. Ngendlela ye-triglyceride (okungukuthi i-Tributyrin).

Bese kuza umbuzo olandelayo –Ngikhethani?Lesi sihloko sinikeza ukuqhathanisa okuhlangene kwakho kokubili.

Inqubo yokukhiqiza

I-sodium butyrate:Ikhiqizwe nge-acid-base reaction ukuze kwakhe usawoti ngendawo yokuncibilika ephezulu.

NaOH+C4 H8 O2=C4 H7 COONA+H2O

(I-Sodium Hydroxide+Butyric Acid = I-Sodium Butyrate+Amanzi)

I-Tributyrin:Ikhiqizwe nge-esterification lapho i-asidi engu-3 butyric enamathiselwe ku-glycerol ukuze kwakheke i-tributyrin.I-Tributyrin inephoyinti eliphansi lokuncibilika.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(I-Glycerol+Butyric Acid = I-Tributyrin + Amanzi)

Iyiphi ehlinzeka nge-asidi ye-butyric eyengeziwe ngomkhiqizo ngamunye we-kg?

KusukaIthebula 1, siyalazi inani le-asidi ye-butyric equkethwe emikhiqizweni ehlukene.Kodwa-ke, kufanele futhi sicabangele ukuthi le mikhiqizo ikhulula kanjani i-butyric acid emathunjini.Njengoba i-sodium butyrate ingusawoti, izoncibilika kalula emanzini akhulula i-butyrate, ngakho-ke singacabanga ukuthi i-100% ye-butyrate evela ku-sodium butyrate izokhishwa lapho ichitheka.Njengoba i-sodium butyrate ihlukana kalula, amafomu avikelwe (okungukuthi i-micro-encapsulation) ye-sodium butyrate izoyisiza ukuthi ithole ukukhululwa kancane kancane kwe-butyrate kuwo wonke amathumbu kuze kube yilapho ikoloni.

I-Tributyrin empeleni iyi-triacylglyceride (TAG), okuyi-ester etholakala ku-glycerol nama-3 fatty acids.I-Tributyrin idinga i-lipase ukuze ikhulule i-butyrate exhunywe ku-glycerol.Nakuba i-tributyrin engu-1 iqukethe i-butyrate engu-3, ​​akuwona wonke ama-butyrate angu-3 aqinisekisiwe ukuthi azokhululwa.Lokhu kungenxa yokuthi i-lipase i-regioselective.Ingakwazi uku-hydrolyse i-triacylglycerides ku-R1 no-R3, kuphela u-R2, noma ngokungaqondile.I-Lipase nayo inokucaciswa kwe-substrate ngokuthi i-enzyme ingakwazi ukuhlukanisa phakathi kwamaketanga e-acyl axhunywe ku-glycerol futhi ngokukhethayo ihlukanise izinhlobo ezithile.Njengoba i-tributyrin idinga i-lipase ukuze ikhiphe i-butyrate yayo, kungase kube khona ukuncintisana phakathi kwe-tributyrin namanye ama-TAG we-lipase.

Ingabe i-sodium butyrate ne-tributyrin izothinta ukudla okuphakelayo?

I-sodium butyrate inephunga elibi elingajabulisi kangako kubantu kodwa elithandwa izilwane ezincelisayo.I-sodium butyrate ibalelwa ku-3.6-3.8% wamafutha obisi obisini lwebele, ngakho-ke, ingasebenza njengento eheha ukudla okuvusa umuzwa wemvelo wokusinda wezilwane ezincelisayo (Ithebula 2).Nokho, ukuze kuqinisekiswe ukukhululwa kancane emathunjini, i-sodium butyrate ivamise ukugqunywa nge-fat matrix coating (okungukuthi i-Palm stearin).Lokhu kusiza futhi ekwehliseni iphunga elibi le-sodium butyrate.

Ngakolunye uhlangothi i-Tributyrin ayinaphunga kodwa inokunambitheka okune-astringent (Ithebula 2).Ukwengeza amanani amakhulu kungase kube nemiphumela engemihle ekudlaleni okuphakelayo.I-Tributyrin iyingqamuzana elizinzile ngokwemvelo elingadlula egunjini lesisu elingenhla lize liqhekezwe yi-lipase emathunjini.Futhi ayiguquguquki ezingeni lokushisa lasekamelweni, ngakho ngokuvamile ayimboziwe.I-Tributyrin ivamise ukusebenzisa i-inert silica dioxide njengesithwali sayo.I-silica dioxide inezimbotshana futhi ingase ingakhiphi ngokugcwele i-tributyrin ngesikhathi sokugaya.I-Tributyrin futhi inomfutho we-vapor ophezulu obangela ukuthi iguquguquke lapho ishiswa.Ngakho-ke, sincoma ukuthi i-tributyrin isetshenziswe ngendlela e-emulsified noma ngendlela evikelekile.