Sodium Butyrate ma ọ bụ tributyrin'Olee nke ị ga-ahọrọ'?

A maara na butyric acid bụ ihe dị mkpa na-enye ume maka mkpụrụ ndụ colonic.Ọzọkwa, ọ bụ n'ezie isi iyi mmanụ ọkụ ma na-enye ihe ruru 70% nke mkpa ike ha niile.Agbanyeghị, enwere ụdị 2 ịhọrọ.Isiokwu a na-enye ntụnyere ha abụọ, na-enyere aka ịza ajụjụ 'nke nke ị ga-ahọrọ'?

Ojiji butyrates dị ka ihe mgbakwunye nri ka enyochala nke ọma ma jiri ya na ọrụ ugbo anụmanụ ruo ọtụtụ iri afọ, nke a na-ebu ụzọ mee ya na ụmụ ehi iji kpalite mmepe rumen n'oge tupu achọta ya na ezì na anụ ọkụkọ.

Ihe mgbakwunye Butyrate egosila ịkwalite uru ahụ (BWG) na ọnụego ntụgharị nri (FCR), belata ọnwụ ma belata mmetụta nke ọrịa ndị metụtara eriri afọ.

Isi mmalite nke butyric acid maka nri anụmanụ na-abịa n'ụdị abụọ:

1. Dị ka nnu (ie sodium butyrate) ma ọ bụ
2. N'ụdị triglyceride (ie Tributyrin).

Mgbe ahụ ajụjụ na-abịa -Kedu nke m ga-ahọrọ?Isiokwu a na-enye ntụnyere n'akụkụ abụọ.

Usoro mmepụta

Sodium butyrate:Emepụtara site na mmeghachi omume acid-base iji mepụta nnu nwere ebe mgbaze dị elu.

NaOH+C4 H8 O2=C4 H7 COONa+H2O

(Sodium Hydroxide+Butyric Acid = Sodium Butyrate+mmiri)

Tributyrin:Emepụtara site na esterification ebe 3 butyric acid jikọtara na glycerol iji mepụta tributyrin.Tributyrin nwere obere agbaze.

C3H8O3+3C4H8O2=C15 H26 O6+3H2O

(Glycerol+Butyric Acid = Tributyrin + Mmiri)

Kedu nke na-enye butyric acid karịa ngwaahịa kwa kilogram?

Site naTebụl 1, anyị maara ọnụọgụ butyric acid dị na ngwaahịa dị iche iche.Otú ọ dị, anyị kwesịkwara ịtụle otú ngwaahịa ndị a si ahapụ butyric acid n'ime eriri afọ.Ebe ọ bụ na sodium butyrate bụ nnu, ọ ga-agbaze ngwa ngwa na mmiri na-ahapụ butyrate, ya mere anyị nwere ike iche na 100% nke butyrate sitere na sodium butyrate ga-ahapụ mgbe agbazere.Dị ka sodium butyrate na-ekewa ngwa ngwa, ụdị echedoro (ya bụ micro-encapsulation) nke sodium butyrate ga-enyere ya aka inweta ntọhapụ nke butyrate na-aga n'ihu na eriri afọ ruo n'ọnụ.

Tributyrin bụ n'ezie triacylglyceride (TAG), nke bụ ester sitere na glycerol na 3 fatty acids.Tributyrin chọrọ lipase iji hapụ butyrate jikọtara na glycerol.Ọ bụ ezie na 1 tributyrin nwere 3 butyrate, ọ bụghị butyrate 3 niile ka ekwenyere na a ga-ahapụ ya.Nke a bụ n'ihi na lipase bụ regioselective.Ọ nwere ike hydrolyse triacylglycerides na R1 na R3, naanị R2, ma ọ bụ na-abụghị kpọmkwem.Lipase nwekwara nkọwapụta mkpụrụ nke na enzyme nwere ike ịmata ọdịiche dị n'agbụ acyl jikọtara na glycerol na ọkachamma nkewa ụdị ụfọdụ.Ebe tributyrin chọrọ lipase ịhapụ butyrate ya, enwere ike inwe asọmpi n'etiti tributyrin na TAG ndị ọzọ maka lipase.

Sodium butyrate na tributyrin ga-emetụta oriri nri?

Sodium butyrate nwere isi na-adịghị mma nke na-adịchaghị mma maka mmadụ mana anụ mamma na-amasị ya.Sodium butyrate bụ 3.6-3.8% nke abụba mmiri ara ehi na mmiri ara, yabụ, nwere ike rụọ ọrụ dị ka ihe na-adọrọ adọrọ na-akpalite ebumnobi ndụ nke ụmụ anụmanụ.Tebụl 2).Agbanyeghị, iji hụ na ntọhapụ nke eriri afọ na-adị nwayọ, sodium butyrate na-ejikarị mkpuchi matriks nke abụba kpuchie ya (ya bụ Palm stearin).Nke a na-enyekwa aka n'ibelata isi ísì nke sodium butyrate.

Tributyrin n'aka nke ọzọ enweghị isi mana ọ nwere uto astringent.Tebụl 2).Ịtinye nnukwu ego nwere ike inwe mmetụta ọjọọ na oriri nri.Tributyrin bụ molekul kwụsiri ike n'okike nke nwere ike ịgafe n'ime akụkụ eriri afọ nke elu ruo mgbe lipase gbajie ya n'ime eriri afọ.Ọ bụkwa ihe na-adịghị agbanwe agbanwe na ụlọ okpomọkụ, ya mere ọ naghị ekpuchi ya.Tributyrin na-ejikarị silica dioxide inert dị ka onye na-ebu ya.Silica dioxide na-agbaze ma nwee ike ọ gaghị ahapụ tributyrin kpamkpam n'oge mgbari nri.Tributyrin nwekwara nrụgide ikuku dị elu na-eme ka ọ na-agbanwe mgbe ọ na-ekpo ọkụ.Ya mere, anyị na-akwado tributyrin ka e jiri ya mee ihe n'ụdị emulsified ma ọ bụ n'ụdị echedoro.