Sodium Butyrate cyangwa tributyrin'ni nde wahitamo'?

Birazwi cyane ko aside ya butyric ari isoko yingufu zingirabuzimafatizo.Ikigeretse kuri ibyo, mubyukuri nisoko yatoranijwe kandi itanga kugeza 70% byingufu zose bakeneye.Ariko, hariho uburyo 2 bwo guhitamo.Iyi ngingo itanga igereranya ryombi, ifasha gusubiza ikibazo 'ninde wahitamo'?

Ikoreshwa rya butyrate nk'inyongeramusaruro ryakozweho ubushakashatsi bwimbitse kandi rikoreshwa mu buhinzi bw’inyamaswa mu myaka mirongo, rikoreshwa bwa mbere mu nyana kugira ngo riteze imbere hakiri kare mbere yo kubona ingurube n’inkoko.

Inyongeramusaruro ya Butyrate yerekanye ko izamura ibiro byumubiri (BWG) hamwe nigipimo cyo guhindura ibiryo (FCR), kugabanya impfu no kugabanya ingaruka zindwara ziterwa ninda.

Inkomoko isanzwe ya aside ya butyric yo kugaburira amatungo iza muburyo 2:

1. Nkumunyu (ni ukuvuga Sodium butyrate) cyangwa
2. Mu buryo bwa triglyceride (ni ukuvuga Tributyrin).

Hanyuma haza ikibazo gikurikira -Nahitamo iki?Iyi ngingo itanga impande zombi kugereranya byombi.

Uburyo bwo gukora

Sodium butyrate:Yakozwe hifashishijwe aside-ishingiro kugirango ibe umunyu hamwe nu mwanya wo gushonga.

NaOH + C4 H8 O2 = C4 H7 COONa + H2O

(Sodium Hydroxide + Acide Butyric = Sodium Butyrate + Amazi)

Tributyrin:Yakozwe binyuze muri esterification aho aside 3 ya butyric ifatanye na glycerol kugirango ikore tributyrin.Tributyrin ifite ingingo yo gushonga.

C3H8O3 + 3C4H8O2 = C15 H26 O6 + 3H2O

(Glycerol + Acide Butyric = Tributyrin + Amazi)

Ninde utanga aside nyinshi ya butyric kubicuruzwa bya kg?

KuvaImbonerahamwe 1, tuzi ingano ya aside ya butyric ikubiye mubicuruzwa bitandukanye.Ariko, dukwiye kandi gutekereza uburyo ibyo bicuruzwa birekura aside butyric mu mara.Kubera ko sodium butyrate ari umunyu, izahita ishonga mumazi arekura butyrate, kubwibyo dushobora gutekereza ko 100% ya butyrate ikomoka kuri sodium butyrate izarekurwa iyo imaze gushonga.Nkuko sodium butyrate itandukana byoroshye, uburyo bukingiwe (ni ukuvuga micro-encapsulation) ya sodium butyrate bizayifasha kugera kurekura buhoro buhoro butyrate mumara yose kugeza kumara.

Tributyrin mubyukuri ni triacylglyceride (TAG), ni ester ikomoka kuri glycerol na aside irike 3.Tributyrin isaba lipase kurekura butyrate ifatanye na glycerol.Nubwo tributyrine 1 irimo butyrate 3, butyrate yose uko ari 3 yemerewe kurekurwa.Ibi biterwa nuko lipase iba regioselective.Irashobora hydrolyse triacylglyceride kuri R1 na R3, R2 gusa, cyangwa idasanzwe.Lipase ifite kandi substrate yihariye muburyo enzyme ishobora gutandukanya iminyururu ya acyl ifatanye na glycerol kandi ikunda gutandukanya ubwoko bumwe na bumwe.Kubera ko tributyrin isaba lipase kurekura butyrate yayo, hashobora kubaho irushanwa hagati ya tributyrin nizindi TAGs za lipase.

Sodium butyrate na tributyrin bizagira ingaruka ku gufata ibiryo?

Sodium butyrate ifite impumuro mbi idashimisha abantu ariko itoneshwa n’inyamabere.Sodium butyrate ihwanye na 3,6-3.8% by'amavuta y’amata mu mashereka, bityo, irashobora gukora nk'ikurura ibiryo bikurura imitekerereze y’inyamabere ()Imbonerahamwe 2).Ariko rero, kugirango irekure gahoro mu mara, sodium butyrate isanzwe iba irimo ibinure bya matrix (urugero: Palm stearin).Ibi kandi bifasha mukugabanya umunuko wa rancid ya sodium butyrate.

Tributyrin kurundi ruhande nta mpumuro nziza ariko ifite uburyohe butangaje (Imbonerahamwe 2).Ongeraho umubare munini birashobora kugira ingaruka mbi kubyo kurya.Tributyrin ni molekile isanzwe ihamye ishobora kunyura mu nzira yo hejuru ya gastrointestinal kugeza igihe ikozwe na lipase mu mara.Ntabwo kandi ihindagurika mubushyuhe bwicyumba, kubwibyo ntabwo isanzwe.Tributyrin mubusanzwe ikoresha dioxyde ya inert silika nkuwayitwaye.Dioxyde ya Silica iroroshye kandi ntishobora kurekura tributyrine mugihe cyo kurya.Tributyrin nayo ifite umuvuduko mwinshi wumuyaga bigatuma ihindagurika iyo ishyushye.Kubwibyo, turasaba tributyrin gukoreshwa haba muburyo bwa emulisile cyangwa muburyo bukingiwe.