Sodium Butyrate ama tributyrin'midkee la dooranayaa'?

Sida caadiga ah waxaa la og yahay in butyric acid ay tahay isha muhiimka ah ee tamarta unugyada colonic.Intaa waxaa dheer, dhab ahaantii waa isha shidaalka ee la doorbido waxayna bixisaa ilaa 70% wadarta baahida tamarta.Si kastaba ha ahaatee, waxaa jira 2 foom oo laga dooran karo.Maqaalkani wuxuu bixiyaa isbarbardhigga labadaba, isagoo ka caawinaya ka jawaabista su'aasha 'midkee la dooranayaa'?

Isticmaalka butyrates sida wax lagu daro quudinta ayaa si weyn loo darsay oo loo isticmaalay beeraha xoolaha muddo dhowr iyo toban sano ah, iyadoo markii ugu horeysay loo isticmaalo weylaha si ay u kiciyaan horumarka hore ee rumen ka hor inta aan la helin isticmaalka doofaarka iyo digaaga.

Waxyaabaha lagu daro Butyrate waxay muujiyeen inay hagaajiyaan korodhka miisaanka jidhka (BWG) iyo quudinta heerarka beddelka (FCR), yaraynta dhimashada iyo yaraynta saameynta cudurrada la xidhiidha mindhicirka.

Ilaha la heli karo ee butyric acid ee quudinta xoolaha waxay u kala baxaan 2 nooc:

1. Sida milix ahaan (ie Sodium butyrate) ama
2. Qaabka triglyceride (ie Tributyrin).

Kadib waxaa imanaysa su'aasha xigta -Midkee ayaan doortaa?Maqaalkani wuxuu bixiyaa isbarbardhigga labada dhinacba.

Habka wax soo saarka

Soodhiyam butyrate:Waxa lagu soo saaray falcelinta acid-saldhigga si loo sameeyo milix leh barta dhalaalaysa sare.

NaOH+C4 H8 O2=C4 H7 COONa+H2O

(Sodium Hydroxide+Butyric Acid = Sodium Butyrate+Biyo)

Tributyrin:Waxa lagu soo saaray esterification halkaas oo 3 butyric acid ay ku dheggan tahay glycerol si uu u sameeyo tributyrin.Tributyrin waxay leedahay dhibic dhalaalaysa oo hooseeya.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(Glycerol+Butyric Acid = Tributyrin + Biyo)

Kee baa siiya aashitada butyric kiilo kasta?

KaShaxda 1, waan ognahay xadiga butyric acid ee ku jira alaabta kala duwan.Si kastaba ha ahaatee, waa in aan sidoo kale tixgelinno sida waxtarka leh ee alaabooyinkani u sii daayaan butyric acid ee xiidmaha.Maadaama butyrate sodium uu yahay milix, waxay si sahal ah ugu milmi doontaa biyaha sii daaya butyrate, sidaas darteed waxaan u qaadan karnaa in 100% butyrate ka soodhiyam butyrate la sii daayo marka la milmo.Sida soodhiyam butyrate u kala go'do, foomamka la ilaaliyo (ie micro-encapsulation) ee sodhiyam butyrate waxay ka caawin doontaa in ay gaadho sii dayn gaabis ah oo joogto ah oo ku jirta mindhicirrada oo dhan ilaa xiidanka.

Tributyrin asal ahaan waa triacylglyceride (TAG), kaas oo ah ester ka soo jeeda glycerol iyo 3 acids dufan.Tributyrin waxay u baahan tahay lipase si ay u sii deyso butyrate ku xiran glycerol.Inkasta oo 1 tributyrin uu ka kooban yahay 3 butyrate, dhammaan 3 butyrate lama dammaanad qaadayo in la sii daayo.Tani waa sababta oo ah lipase waa dib-u-doorasho.Waxay hydrolyse kartaa triacylglycerides at R1 iyo R3, kaliya R2, ama aan si gaar ah.Lipase waxa kale oo uu leeyahay substrate gaar ah in ensaymku uu kala saari karo inta u dhaxaysa silsiladaha acyl ee ku xidhan glycerol iyo doorbidida kala-goynta noocyada qaarkood.Maadaama tributyrin uu u baahan yahay lipase si uu u sii daayo butyrate, waxaa jiri kara tartan u dhexeeya tributyrin iyo TAGyada kale ee lipase.

Soodhiyam butyrate iyo tributyrin ma saameyn doonaan qaadashada quudinta?

Sodium butyrate waxay leedahay ur xun oo aan u roonayn bini'aadamka laakiin ay jecel yihiin naasleyda.Sodium butyrate waxay xisaabisaa 3.6-3.8% dufanka caanaha ee caanaha naaska, sidaa darteed, waxay u dhaqmi kartaa sidii quudin soo jiidasho leh oo kicisa dareenka badbaadada ee naasleydaShaxda 2).Si kastaba ha ahaatee, si loo hubiyo sii daynta qunyar socodka mindhicirrada, sodium butyrate waxaa sida caadiga ah lagu dahaadhay matrix baruurta (ie Palm stearin).Tani waxay sidoo kale kaa caawinaysaa yaraynta urta rancid ee butyrate sodium.

Dhanka kale Tributyrin waa ur la'aan laakiin waxay leedahay dhadhan astringent (Shaxda 2).Ku darida xaddi badan waxay saameyn xun ku yeelan kartaa qaadashada quudinta.Tributyrin waa unug dabiici ah oo deggan oo dhex mari kara mareenka caloosha iyo mindhicirka sare ilaa ay ka dillaacdo lipase ee mindhicirka.Sidoo kale ma aha mid kacsan heerkulka qolka, sidaa darteed guud ahaan lama dahaadho.Tributyrin caadi ahaan waxay u isticmaashaa silica dioxide inert sida sideheeda.Silica dioxide waa dalool waxaana laga yaabaa inaysan si buuxda u sii deyn tributyrin inta lagu jiro dheefshiidka.Tributyrin waxa kale oo uu leeyahay cadaadis uumiga sareeyo taaso keenta in ay noqoto mid kacsan marka la kululeeyo.Sidaa darteed, waxaan kugula talineynaa in tributyrin loo isticmaalo qaab emulsified ama qaab la ilaaliyo.