Sodium Butyrate kapa tributyrin'ho khetha efe'?

Hoa tsebahala hore butyric acid ke mohloli oa bohlokoa oa matla bakeng sa lisele tsa colonic.Ho feta moo, ke mohloli o ratoang oa mafura 'me o fana ka 70% ea litlhoko tsohle tsa bona tsa matla.Leha ho le joalo, ho na le mefuta e 2 eo u ka khethang ho eona.Sengoliloeng sena se fana ka papiso ea bobeli, ho thusa ho araba potso e reng 'ho khetha efe'?

Tšebeliso ea butyrate joalo ka setlatsetso sa phepelo e 'nile ea ithutoa haholo le ho sebelisoa temong ea liphoofolo ka lilemo tse mashome a 'maloa, e sebelisoa pele ho manamane ho susumetsa tsoelo-pele ea pele ea rumen pele e fumana tšebeliso ea likolobe le likhoho.

Li-additives tsa butyrate li bonts'itse ho ntlafatsa boima ba 'mele (BWG) le litefiso tsa phepelo ea phepelo (FCR), ho fokotsa ho shoa le ho fokotsa tšusumetso ea mafu a amanang le mala.

Mehloli e fumanehang hangata ea asiti ea butyric bakeng sa phepelo ea liphoofolo e tla ka mefuta e 'meli:

1. Joalo ka letsoai (ke hore sodium butyrate) kapa
2. Ka sebopeho sa triglyceride (ke hore, Tributyrin).

Ebe ho tla potso e latelang -Ke khetha efe?Sengoliloeng sena se fana ka papiso ea mahlakore ka bobeli.

Mokhoa oa tlhahiso

Sodium butyrate:E hlahisoa ka mokhoa oa acid-base reaction ho etsa letsoai le nang le ntlha e phahameng ea ho qhibiliha.

NaOH+C4 H8 O2=C4 H7 COONA+H2O

(Sodium Hydrooxide+Butyric Acid = Sodium Butyrate+Metsi)

Tributyrin:E hlahisoa ka esterification moo 3 butyric acid e khomaretsoeng ho glycerol ho etsa tributyrin.Tributyrin e na le ntlha e tlase ea ho qhibiliha.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(Glycerol+Butyric Acid = Tributyrin + Metsi)

Ke efe e fanang ka asiti e eketsehileng ea butyric ka kg sehlahisoa?

Ho tlohaLethathamo la 1, re tseba palo ea asiti ea butyric e fumanehang lihlahisoa tse fapaneng.Leha ho le joalo, re boetse re lokela ho nahana ka hore na lihlahisoa tsena li lokolla butyric acid joang ka maleng.Kaha sodium butyrate ke letsoai, e tla qhibiliha habonolo metsing a lokolla butyrate, kahoo re ka nahana hore 100% ea butyrate e tsoang ho sodium butyrate e tla lokolloa ha e qhibiliha.Ha sodium butyrate e ikarola habonolo, mefuta e sirelelitsoeng (e leng micro-encapsulation) ea sodium butyrate e tla e thusa ho fumana butyrate e tsoelang pele butyrate ho pholletsa le mala ho ea fihla colon.

Hantle-ntle Tributyrin ke triacylglyceride (TAG), e leng ester e nkiloeng ho glycerol le 3 fatty acids.Tributyrin e hloka lipase ho lokolla butyrate e kopantsoeng le glycerol.Leha 1 tributyrin e na le 3 butyrate, ha se kaofela 3 butyrate e netefalitsoeng hore e tla lokolloa.Sena ke hobane lipase ke regioselective.E ka etsa hydrolyse triacylglycerides ho R1 le R3, feela R2, kapa eseng ka ho hlaka.Lipase e boetse e na le substrate e ikhethang ka hore enzyme e ka khetholla pakeng tsa liketane tsa acyl tse khomaretsoeng ho glycerol le ho qhaqha mefuta e itseng.Kaha tributyrin e hloka lipase ho lokolla butyrate ea eona, ho ka ba le tlholisano lipakeng tsa tributyrin le li-TAG tse ling bakeng sa lipase.

Na sodium butyrate le tributyrin li tla ama ho ja lijo?

Sodium butyrate e na le monko o khopisang o seng monate ho batho empa o ratoa ke liphoofolo tse anyesang.Sodium butyrate e etsa karolo ea 3.6-3.8% ea mafura a lebese lebeseng la letsoele, ka hona, e ka sebetsa joalo ka sehokelo sa phepelo se tsosang tšekamelo ea tlhaho ea ho phela ea liphoofolo tse anyesang.Lethathamo la 2).Leha ho le joalo, ho etsa bonnete ba ho lokolloa butle ka maleng, sodium butyrate hangata e koaheloa ka mafura a matrix (ke hore Palm stearin).Sena se boetse se thusa ho fokotsa monko o monate oa sodium butyrate.

Ka lehlakoreng le leng, Tributyrin ha e na monko empa e na le tatso ea astringent (Lethathamo la 2).Ho eketsa palo e kholo ho ka ba le litlamorao tse mpe mabapi le ho ja lijo.Tributyrin ke molek'hule e tsitsitseng ka tlhaho e ka fetang ka har'a pampiri e ka holimo ea mala ho fihlela e petsoha ke lipase ka maleng.Hape ha e fetohe mocheso oa kamore, kahoo hangata ha e koahetsoe.Hangata, Tributyrin e sebelisa silika ea inert e le mojari oa eona.Silica dioxide e porous 'me e ka' na ea se ke ea lokolla tributyrin ka botlalo nakong ea tšilo ea lijo.Tributyrin e boetse e na le khatello e phahameng ea mouoane e etsang hore e fetohe ha e futhumala.Ka hona, re khothaletsa tributyrin hore e sebelisoe ka mokhoa oa emulsified kapa ka mokhoa o sirelelitsoeng.