Potassium formate, thawj zaug uas tsis yog tshuaj tua kab mob pub additive tau pom zoo los ntawm European Union hauv 2001 thiab tau pom zoo los ntawm Ministry of Agriculture ntawm Tuam Tshoj xyoo 2005, tau sau ib daim ntawv thov tseem ceeb rau ntau tshaj 10 xyoo, thiab ntau cov ntaub ntawv tshawb fawb hauv tsev thiab thoob ntiaj teb tau tshaj tawm nws cov teebmeem. nyob rau ntau theem ntawm kev loj hlob ntawm npua.

Necrotizing enteritis yog kab mob nqaij qaib thoob ntiaj teb tshwm sim los ntawm cov kab mob gram-zoo (Clostridium perfringens), uas yuav ua rau kom tuag ntawm broilers thiab txo qhov kev loj hlob ntawm qaib nyob rau hauv subclinical yam.Ob qho ntawm cov txiaj ntsig no ua rau tsiaj noj qab haus huv thiab ua rau muaj kev lag luam loj heev rau kev tsim qaib.Hauv kev tsim khoom tiag tiag, cov tshuaj tua kab mob feem ntau yog ntxiv rau pub kom tiv thaiv qhov tshwm sim ntawm necrotizing enteritis.Txawm li cas los xij, kev hu xov tooj rau kev txwv tsis pub siv tshuaj tua kab mob hauv kev pub noj yog nce ntxiv, thiab lwm yam kev daws teeb meem yuav tsum tau hloov cov kev tiv thaiv ntawm cov tshuaj tua kab mob.Txoj kev tshawb nrhiav pom tias ntxiv cov organic acids lossis lawv cov ntsev rau cov khoom noj tuaj yeem cuam tshuam cov ntsiab lus ntawm Clostridium perfringens, yog li txo qhov tshwm sim ntawm necrotizing enteritis.Potassium formate yog decomposed rau hauv formic acid thiab potassium formate nyob rau hauv txoj hnyuv.Vim yog covalent daim ntawv cog lus rau qhov kub thiab txias, qee cov formic acid nkag mus rau hauv cov hnyuv.Qhov kev sim no siv nqaij qaib kis nrog necrotizing enteritis ua qauv kev tshawb fawb los tshawb xyuas cov teebmeem ntawmpoov tshuaj formatentawm nws txoj kev loj hlob, plab hnyuv microbiota, thiab luv saw fatty acid cov ntsiab lus.

1. Cov nyhuv ntawmPotassium Diformatentawm Kev Loj Hlob Ua Haujlwm ntawm Broilers Kab Mob Necrotizing Enteritis.

Cov txiaj ntsig kev sim tau pom tias potassium formate tsis muaj qhov cuam tshuam loj rau kev loj hlob ntawm broilers nrog lossis tsis muaj necrotizing enteritis kab mob, uas zoo ib yam nrog cov txiaj ntsig kev tshawb fawb ntawm Hernandez li al.(2006).Nws tau pom tias tib koob tshuaj calcium formate tsis muaj qhov cuam tshuam rau qhov hnyav txhua hnub thiab pub piv ntawm broilers, tab sis thaum ntxiv calcium formate mus txog 15 g / kg, nws txo qis kev loj hlob ntawm broilers (Patten thiab Waldroup. Ib., 1988).Txawm li cas los xij, Selle et al.(2004) pom tias ntxiv 6 g / kg ntawm poov tshuaj formate rau cov zaub mov ua rau kom qhov hnyav nce thiab noj cov nqaij qaib broiler los ntawm 16-35 hnub.Tam sim no muaj qee qhov kev tshawb fawb qhia txog lub luag haujlwm ntawm cov organic acids hauv kev tiv thaiv tus kab mob necrotizing enteritis.Qhov kev sim no pom tau hais tias ntxiv 4 g / kg poov tshuaj rau hauv cov zaub mov txo qis kev tuag ntawm cov nqaij qaib, tab sis tsis muaj kev sib raug zoo ntawm kev txo qis hauv kev tuag thiab cov poov tshuaj formate ntxiv.

2. Cov nyhuv ntawmPotassium Diformatentawm Cov Ntsiab Lus Microbial nyob rau hauv cov ntaub so ntswg thiab kab mob ntawm broilers kis nrog necrotizing enteritis

Qhov sib ntxiv ntawm 45mg / kg bacitracin zinc nyob rau hauv pub txo cov neeg tuag ntawm broilers kis nrog necrotizing enteritis, thiab tib lub sij hawm txo cov ntsiab lus ntawm Clostridium perfringens nyob rau hauv jejunum, uas yog raws li kev tshawb fawb ntawm Kocher li al.(2004).Tsis muaj qhov cuam tshuam tseem ceeb ntawm kev noj zaub mov potassium diformate ntxiv rau cov ntsiab lus ntawm Clostridium perfringens hauv jejunum ntawm broilers kis nrog necrotizing enteritis rau 15 hnub.Walsh et al.(2004) pom tias kev noj zaub mov acidity siab muaj qhov cuam tshuam tsis zoo rau cov organic acids, yog li ntawd, cov acidity siab ntawm cov zaub mov muaj protein ntau tuaj yeem txo cov kev tiv thaiv ntawm potassium formate ntawm necrotizing enteritis.Qhov kev sim no kuj pom tias potassium formate nce cov ntsiab lus ntawm lactobacilli hauv cov leeg nqaij ntawm 35d broiler qaib, uas tsis sib haum nrog Knarreborg li al.(2002) pom nyob rau hauv vitro uas potassium formate txo qhov kev loj hlob ntawm lactobacilli hauv npua plab.

3.Cov nyhuv ntawm potassium 3-dimethylformate rau cov ntaub so ntswg pH thiab luv saw fatty acid cov ntsiab lus nyob rau hauv broiler qaib kis nrog necrotizing enteritis

Cov tshuaj tua kab mob ntawm cov organic acids ntseeg tau tias feem ntau tshwm sim nyob rau sab sauv ntawm lub plab zom mov.Cov txiaj ntsig ntawm qhov kev sim no tau pom tias potassium dicarboxylate nce cov ntsiab lus ntawm cov kua qaub hauv duodenum ntawm 15 hnub thiab jejunum ntawm 35 hnub.Mroz (2005) pom tias muaj ntau yam uas cuam tshuam rau kev ua ntawm cov organic acids, xws li pub pH, buffering / acidity, thiab kev noj haus electrolyte tshuav.Tsawg acidity thiab siab electrolyte tshuav nyiaj li cas hauv kev noj haus tuaj yeem txhawb kev sib cais ntawm potassium formate rau hauv formic acid thiab potassium formate.Yog li ntawd, theem tsim nyog ntawm acidity thiab electrolyte tshuav nyiaj li cas nyob rau hauv cov khoom noj yuav txhim khu kev txhim kho kev loj hlob ntawm broilers los ntawm poov tshuaj formate thiab nws tiv thaiv cov nyhuv ntawm necrotizing enteritis.

Xaus

Cov txiaj ntsig ntawmpoov tshuaj formatentawm tus qauv ntawm necrotizing enteritis nyob rau hauv broiler qaib pom tias poov tshuaj formate tuaj yeem txo qhov kev loj hlob ntawm cov qaib broiler nyob rau hauv qee yam mob los ntawm kev ua kom lub cev hnyav thiab txo kev tuag, thiab tuaj yeem siv los ua cov khoom noj ntxiv los tswj kev kis tus kab mob necrotizing enteritis hauv broiler qaib.