Tributyrin supplementation nyob rau hauv cov ntses thiab crustacean khoom noj khoom haus

Short-chain fatty acids, nrog rau butyrate thiab nws cov ntaub ntawv muab tau los, tau siv los ua cov khoom noj khoom haus kom rov qab los yog ua kom muaj kev cuam tshuam tsis zoo ntawm cov khoom xyaw uas tau los ntawm cov nroj tsuag hauv cov khoom noj hauv dej, thiab muaj ntau qhov ua tau zoo ntawm lub cev thiab kev noj qab haus huv los txhim kho cov teebmeem hauv tsiaj txhu thiab tsiaj txhu.Tributyrin, butyric acid derivate, tau raug soj ntsuam raws li ib qho ntxiv hauv cov khoom noj ntawm cov tsiaj ua liaj ua teb, nrog cov txiaj ntsig tau zoo hauv ntau hom.Hauv cov ntses thiab crustaceans, kev noj zaub mov suav nrog tributyrin yog qhov tsis ntev los no thiab tau kawm tsawg dua tab sis cov txiaj ntsig tau qhia tias nws yuav muaj txiaj ntsig zoo rau cov tsiaj hauv dej.Qhov no yog ib qho tseem ceeb tshwj xeeb tshaj yog rau cov tsiaj carnivorous, uas nws cov zaub mov yuav tsum tau ua kom zoo rau kev txo qis cov ntsiab lus ntawm cov ntses ntses los txhim kho ib puag ncig thiab kev lag luam ruaj khov ntawm kev lag luam.Txoj haujlwm tam sim no qhia txog tributyrin thiab nthuav tawm cov txiaj ntsig tseem ceeb ntawm nws txoj kev siv los ntawm kev noj zaub mov ntawm butyric acid hauv kev pub rau cov tsiaj hauv dej.Lub hom phiaj tseem ceeb yog muab rau aquaculture hom thiab yuav ua li cas tributyrin, raws li kev pub ntxiv, tuaj yeem pab txhawb kev ua kom zoo tshaj cov nroj tsuag aquafeeds.

Ntsiab lus

aquafeed, butyrate, butyric acid, luv-chain fatty acids, triglycerides

1. Butyric acid thiab plab hnyuv noj qab haus huvCov tsiaj hauv dej muaj cov plab zom mov luv, lub sijhawm khaws cov zaub mov luv hauv txoj hnyuv, thiab feem ntau ntawm lawv tsis muaj plab.Txoj hnyuv muaj ob txoj haujlwm ntawm kev zom thiab nqus.Cov hnyuv tseem ceeb heev rau cov tsiaj hauv dej, yog li nws muaj kev xav tau ntau dua rau cov khoom noj.Cov tsiaj hauv dej muaj kev xav tau ntau rau cov protein.Ntau cov ntaub ntawv cog qoob loo uas muaj cov khoom noj muaj txiaj ntsig zoo, xws li paj rwb rapeseed pluas noj, feem ntau yog siv rau hauv cov dej pub noj los hloov cov ntses pluas noj, uas ua rau cov protein deterioration los yog rog oxidation, ua rau cov hnyuv puas tsuaj rau cov tsiaj hauv dej.Cov protein tsis zoo tuaj yeem txo qhov siab ntawm plab hnyuv mucosa, qhov muag plooj lossis txawm tias tshem tawm cov hlwb epithelial, thiab ua kom cov vacuoles, uas tsis tsuas yog txwv kev zom thiab nqus cov khoom noj, tab sis kuj cuam tshuam rau kev loj hlob ntawm cov tsiaj hauv dej.Yog li ntawd, nws yog ib qho tseem ceeb heev los tiv thaiv txoj hnyuv ntawm cov tsiaj hauv dej.Butyric acid yog ib tug luv luv saw fatty acid muab los ntawm fermentation ntawm plab hnyuv kab mob xws li kab mob lactic acid thiab bifidobacteria.Butyric acid tuaj yeem nqus tau ncaj qha los ntawm plab hnyuv epithelial hlwb, uas yog ib qho ntawm lub zog tseem ceeb ntawm txoj hnyuv epithelial hlwb.Nws tuaj yeem txhawb kev loj hlob thiab kev loj hlob ntawm cov kab mob hauv plab hnyuv, tswj kev ncaj ncees ntawm cov hnyuv epithelial hlwb, thiab txhim kho cov hnyuv mucosal barrier;Tom qab butyric acid nkag mus rau hauv cov kab mob hlwb, nws yog decomposed rau hauv butyrate ions thiab hydrogen ions.Cov ntsiab lus siab ntawm hydrogen ions tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob phem xws li Escherichia coli thiab Salmonella, thaum cov kab mob muaj txiaj ntsig zoo xws li cov kab mob lactic acid proliferate ntau vim lawv cov kua qaub tiv thaiv, yog li optimizing cov qauv ntawm plab zom mov;Butyric acid tuaj yeem cuam tshuam kev tsim khoom thiab kev nthuav qhia ntawm proinflammatory yam hauv plab hnyuv mucosa, inhibit inflammatory cov tshuaj tiv thaiv, thiab alleviate plab hnyuv o;Butyric acid muaj cov haujlwm tseem ceeb hauv lub cev hauv plab hnyuv.

2. Glyceryl butyrate

Butyric acid muaj ib qho tsis hnov tsw tsw thiab yooj yim rau volatilize, thiab nws yog ib qho nyuaj rau mus txog qhov kawg ntawm txoj hnyuv mus ua lub luag hauj lwm tom qab noj los ntawm cov tsiaj, yog li nws tsis tuaj yeem siv ncaj qha rau hauv kev tsim khoom.Glyceryl butyrate yog fatty khoom ntawm butyric acid thiab glycerin.Butyric acid thiab glycerin yog khi los ntawm covalent bonds.Lawv ruaj khov ntawm pH1-7 txog 230 ℃.Tom qab noj los ntawm cov tsiaj, glyceryl butyrate tsis decompose nyob rau hauv lub plab, tab sis decomposes rau hauv butyric acid thiab glycerin nyob rau hauv txoj hnyuv raws li kev txiav txim ntawm pancreatic lipase, maj mam tso butyric acid.Glyceryl butyrate, ua cov khoom noj ntxiv, yooj yim siv, nyab xeeb, tsis muaj tshuaj lom, thiab muaj qhov tshwj xeeb tsw.Nws tsis tsuas yog daws qhov teeb meem uas butyric acid nyuaj rau ntxiv raws li cov kua thiab tsw tsw phem, tab sis kuj txhim kho qhov teeb meem uas butyric acid nyuaj kom ncav cuag txoj hnyuv thaum siv ncaj qha.Nws raug suav hais tias yog ib qho zoo tshaj plaws butyric acid derivatives thiab tshuaj tiv thaiv histamine.

2.1 Glyceryl Tributyrate thiab Glyceryl Monobutyrate

TributyrinNws muaj 3 molecules ntawm butyric acid thiab 1 molecule ntawm glycerol.Tributyrin maj mam tso tawm butyric acid nyob rau hauv cov hnyuv los ntawm pancreatic lipase, ib feem ntawm cov uas tau tso tawm nyob rau hauv pem hauv ntej ntawm txoj hnyuv, thiab ib feem ntawm cov uas muaj peev xwm mus txog rau sab nraum qab ntawm txoj hnyuv mus ua lub luag hauj lwm;Monobutyric acid glyceride yog tsim los ntawm ib lub molecule ntawm butyric acid khi rau thawj qhov chaw ntawm glycerol (Sn-1 site), uas muaj hydrophilic thiab lipophilic zog.Nws tuaj yeem ncav cuag qhov kawg ntawm txoj hnyuv nrog cov kua txiv digestive.Qee cov kua qaub butyric raug tso tawm los ntawm pancreatic lipase, thiab qee qhov yog nqus ncaj qha los ntawm cov kab mob hauv plab hnyuv epithelial.Nws yog decomposed rau hauv butyric acid thiab glycerol nyob rau hauv cov hnyuv mucosal hlwb, txhawb kev loj hlob ntawm plab hnyuv villi.Glyceryl butyrate muaj molecular polarity thiab nonpolarity, uas tuaj yeem nkag mus rau hauv hydrophilic lossis lipophilic cell phab ntsa membrane ntawm cov kab mob tseem ceeb, cuam tshuam cov kab mob hlwb, rhuav tshem cov qauv ntawm tes, thiab tua cov kab mob phem.Monobutyric acid glyceride muaj cov tshuaj tua kab mob muaj zog ntawm cov kab mob gram-zoo thiab cov kab mob gram-tsis zoo, thiab muaj cov kab mob zoo dua.

2.2 Kev siv cov glyceryl butyrate hauv cov khoom dej

Glyceryl butyrate, raws li ib tug derivative ntawm butyric acid, muaj peev xwm ua tau zoo tso butyric acid nyob rau hauv qhov kev txiav txim ntawm txoj hnyuv pancreatic lipase, thiab tsis muaj ntxhiab, ruaj khov, nyab xeeb thiab tsis muaj residue.Nws yog ib qho kev xaiv zoo tshaj plaws rau cov tshuaj tua kab mob thiab siv dav hauv aquaculture.Zhai Qiuling et al.pom tau tias thaum 100-150 mg / kg tributylglycerol ester tau ntxiv rau qhov pub, qhov hnyav nce, tus nqi loj hlob, kev ua ub no ntawm ntau yam digestive enzymes thiab qhov siab ntawm plab hnyuv villi ua ntej thiab tom qab ntxiv ntawm 100 mg / kg tributylglycerol ester tuaj yeem yuav tsum tau nce ntxiv;Tang Qifeng thiab lwm tus kws tshawb fawb pom tau tias ntxiv 1.5g / kg tributylglycerol ester rau kev pub tuaj yeem txhim kho kev loj hlob ntawm Penaeus vannamei, thiab txo qis tus naj npawb ntawm cov kab mob vibrio hauv txoj hnyuv;Jiang Ying et al.pom tias ntxiv 1g / kg ntawm tributyl glyceride rau cov khoom noj tuaj yeem ua rau qhov hnyav nce ntawm Allogynogenetic crucian carp, txo cov coefficient pub, thiab ua kom cov haujlwm ntawm superoxide dismutase (SOD) hauv hepatopancreas;Qee qhov kev tshawb fawb pom tias qhov sib ntxiv ntawm 1000 mg / kgtributyl glyceridesKev noj zaub mov tuaj yeem ua rau muaj kev ua haujlwm ntawm plab hnyuv superoxide dismutase (SOD) ntawm Jian carp.

Post lub sij hawm: Jan-05-2023