Ukuxhaswa kwe-Tributyrin kwiintlanzi kunye ne-crustacean isondlo

I-fatty chain acids efutshane, kubandakanywa i-butyrate kunye neefom zayo ezifunyenweyo, zisetyenziswe njengezongezo zokutya ukubuyisela umva okanye ukuphucula iziphumo ezibi ezinokubakho zezithako ezivela kwizityalo kwizidlo ze-aquaculture, kwaye zibe neziphumo ezininzi ezibonakaliswe kakuhle zomzimba kunye nokuphucula impilo ezanyisayo nemfuyo.I-Tributyrin, i-butyric acid derivate, iye yavavanywa njengesongezelelo kwisondlo sezilwanyana ezifuywayo, kunye neziphumo ezithembisayo kwiintlobo ezininzi.Kwiintlanzi kunye nee-crustaceans, ukufakwa kokutya kwe-tributyrin kutsha nje kwaye akufundwanga kancinci kodwa iziphumo zibonisa ukuba kunokuba luncedo kakhulu kwizilwanyana zasemanzini.Oku kubaluleke kakhulu kwiintlobo zezilwanyana ezitya inyama, ezikutya kwazo kufuneka kuphuculwe ukuze kuncitshiswe isiqulatho somgubo wentlanzi ukunyusa izinga lokusingqongileyo nozinzo lwezoqoqosho lweli candelo.Umsebenzi wangoku ubonakalisa i-tributyrin kwaye ubonisa iziphumo eziphambili zokusetyenziswa kwayo njengomthombo wokutya we-butyric acid kwisondlo seentlobo zasemanzini.Olona gxininiso lunikezelwa kwiintlobo zezityalo zasemanzini kunye nendlela i-tributyrin, njengesongezelelo sesondlo, enokuba negalelo ngayo ekuphuculeni ukutya okusekwe kwizityalo.

Amagama angundoqo

aquafeed, butyrate, butyric acid, short-chain fatty acids, triglyceride

1. I-Butyric acid kunye nempilo yamathumbuIzilwanyana zasemanzini zinezitho ezimfutshane zokugaya, ixesha elifutshane lokugcina ukutya emathunjini, kwaye uninzi lwazo alunasisu.Amathumbu anemisebenzi emibini yokwetyisa kunye nokufunxa.Amathumbu abaluleke kakhulu kwizilwanyana zasemanzini, ngoko ke aneemfuno eziphezulu zemathiriyeli yokutya.Izilwanyana zasemanzini zinemfuno ephezulu yeprotheyini.Inani elikhulu lezixhobo zeprotheyini zezityalo eziqulethe izinto ezichasene nesondlo, ezifana nomgubo we-cotton rapeseed, zidla ngokusetyenziswa kwisondlo sasemanzini ukubuyisela ukutya kweentlanzi, ezithanda ukuwohloka kweprotheyini okanye i-oxidation yamafutha, ebangela umonakalo wamathumbu kwizilwanyana zasemanzini.Umthombo weprotheyini esemgangathweni unokunciphisa kakhulu ukuphakama kwe-intestinal mucosa, i-blur okanye i-epithelial cell cell, kunye nokwandisa i-vacuoles, engathinteli nje ukugaywa kunye nokufunxwa kwezondlo zokutya, kodwa kuchaphazela ukukhula kwezilwanyana zasemanzini.Ngoko ke, kungxamiseke kakhulu ukukhusela amathumbu ezilwanyana zasemanzini.Iasidi yeButyric sisixokelelwano esifutshane se-fatty acid ephuma ekuvubeleni kweebhaktheriya eziluncedo emathunjini njengebhaktiriya ye-lactic acid kunye ne-bifidobacteria.Iasidi yeButyric inokufunxwa ngokuthe ngqo ziiseli ze-epithelial zamathumbu, eyona mithombo yamandla ephambili yeeseli ze-epithelial zamathumbu.Inokukhuthaza ukwanda kunye nokuvuthwa kweeseli zesisu, ukugcina ingqibelelo yeeseli ze-epithelial zamathumbu, kunye nokuphucula umqobo we-intestinal mucosal barrier;Emva kokuba i-asidi ye-butyric ingene kwiiseli zebhaktheriya, ibolile ibe yi-butyrate ion kunye ne-hydrogen ion.Uxinzelelo oluphezulu lwe-hydrogen ion lunokuthintela ukukhula kweebhaktheriya ezinobungozi ezifana ne-Escherichia coli kunye ne-Salmonella, ngelixa iibhaktheriya ezinenzuzo ezifana neebhaktheriya ze-lactic acid zikhula ngobuninzi ngenxa yokunyanzeliswa kwe-asidi, ngaloo ndlela kwandisa isakhiwo se-digestive tract flora;I-asidi ye-Butyric inokuthintela ukuveliswa kunye nokubonakaliswa kwezinto eziphazamisayo kwi-intestinal mucosa, inqanda ukusabela okuvuthayo, kunye nokunciphisa ukuvuvukala kwamathumbu;I-asidi ye-Butyric inemisebenzi ebalulekileyo ye-physiological kwimpilo yamathumbu.

2. I-Glyceryl butyrate

Iasidi yeButyric inevumba elibi kwaye kulula ukuvuthuza, kwaye kunzima ukufikelela emva kwamathumbu ukuze idlale indima emva kokuba ityiwe zizilwanyana, ngoko ayinakusetyenziswa ngokuthe ngqo kwimveliso.I-Glyceryl butyrate yimveliso enamafutha e-butyric acid kunye ne-glycerin.I-asidi ye-Butyric kunye ne-glycerin ziboshwe ngamabhondi adibeneyo.Zizinzile ukusuka kwi-pH1-7 ukuya kuma-230 ℃.Emva kokuba idliwe zizilwanyana, i-glyceryl butyrate ayiboli esiswini, kodwa ibola kwi-asidi ye-butyric kunye ne-glycerin emathunjini phantsi kwesenzo se-pancreatic lipase, ngokukhawuleza ikhupha i-butyric acid.I-Glyceryl butyrate, njengesongezo sokutya, ikulungele ukusetyenziswa, ikhuselekile, ayinayo ityhefu, kwaye inencasa ekhethekileyo.Ayinakusombulula ingxaki kuphela ukuba i-asidi ye-butyric kunzima ukongeza njengolwelo kunye nevumba elibi, kodwa iphucula ingxaki yokuba i-asidi ye-butyric kunzima ukufikelela kwi-intestinal tract xa isetyenziswe ngokuthe ngqo.Ithathwa njengenye yezona zinto ziphuma kwi butyric acid kunye neemveliso ze-anti histamine.

2.1 I-Glyceryl Tributyrate kunye neGlyceryl Monobutyrate

I-Tributyriniqulethwe iamolekyu ezi-3 ze-butyric acid kunye ne-molecule ye-glycerol eyi-1.I-Tributyrin ikhupha kancinane iasidi ye-butyric emathunjini ngokusebenzisa i-pancreatic lipase, inxalenye yayo ephuma phambi kwamathumbu, kwaye inxalenye yayo inokufikelela emva kwamathumbu ukuze idlale indima;I-monobutyric acid glyceride yenziwe yi-molecule enye ye-butyric acid ebophelelayo kwindawo yokuqala ye-glycerol (isayithi ye-Sn-1), eneempawu ze-hydrophilic kunye ne-lipophilic.Inokufikelela ekupheleni kwamathumbu kunye nejusi yokugaya.Enye iasidi ye-butyric ikhutshwa yi-pancreatic lipase, kwaye enye ifunxwa ngokuthe ngqo ziiseli ze-epithelial zamathumbu.Ichithwa kwi-asidi ye-butyric kunye ne-glycerol kwiiseli ze-mucosal zamathumbu, ukukhuthaza ukukhula kwe-intestinal villi.I-Glyceryl butyrate ine-molecular polarity kunye ne-nonpolarity, enokuthi ingene ngokufanelekileyo kwi-hydrophilic okanye i-lipophilic cell wall membrane ye-bacteria ephambili ye-pathogenic, ihlasele iiseli zebhaktiriya, itshabalalise ubume beeseli, kwaye ibulale ibhaktheriya eyingozi.I-Monobutyric acid glyceride inefuthe elinamandla lokulwa ne-antibacterial kwiibhaktheriya zegram-positive kunye neebhaktheriya zegram-negative, kwaye inempembelelo engcono yokulwa ne-antibacterial.

2.2 Ukusetyenziswa kwe-glyceryl butyrate kwiimveliso zasemanzini

I-Glyceryl butyrate, njenge-derivative ye-butyric acid, inokukhulula ngokufanelekileyo i-asidi ye-butyric phantsi kwesenzo se-intestinal pancreatic lipase, kwaye ayinavumba, izinzile, ikhuselekile kwaye i-residue free.Yenye yeendlela ezizezinye ezinokusetyenziswa kwi-antibiotics kwaye isetyenziswa kakhulu kwi-aquaculture.UZhai Qiuling et al.wabonisa ukuba xa i-100-150 mg / kg i-tributylglycerol ester yongezwa kwisondlo, izinga lokuzuza ubunzima, izinga elithile lokukhula, imisebenzi yee-enzymes zokugaya kunye nokuphakama kwe-intestinal villi ngaphambi nangemva kokongezwa kwe-100 mg / kg i-tributylglycerol ester ingakwazi. ukwanda kakhulu;I-Tang Qifeng kunye nabanye abaphandi bafumanisa ukuba ukongeza i-1.5g / kg i-tributylglycerol ester kwisondlo kunokuphucula kakhulu ukusebenza kokukhula kwePenaeus vannamei, kunye nokunciphisa kakhulu inani le-pathogenic vibrio emathunjini;Jiang Yingying et al.wafumanisa ukuba ukongeza i-1g / kg ye-tributyl glyceride kwisondlo kunokwandisa kakhulu izinga lokufumana ubunzima be-Allogynogenetic crucian carp, ukunciphisa i-coefficient yokutya, kunye nokwandisa umsebenzi we-superoxide dismutase (SOD) kwi-hepatopancreas;Ezinye izifundo zibonise ukuba ukongezwa kwe-1000 mg / kgi-tributyl glycerideekutyeni kunokwandisa kakhulu intestinal superoxide dismutase (SOD) umsebenzi we Jian carp.

Ixesha lokuposa: Jan-05-2023